Homocysteine induces mitochondrial dysfunction involving the crosstalk between oxidative stress and mitochondrial pSTAT3 in rat ischemic brain

• Published in: Scientific reports Vol. 7; no. 1; pp. 6932 - 12
• Main Authors: Chen, Shuang, Dong, Zhiping, Zhao, Yaqian, Sai, Na, Wang, Xuan, Liu, Huan, Huang, Guowei, Zhang, Xumei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.07.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/51; 14/63; 38; 38/1; 631/378/1689/534; 692/617/375/534; 8-Hydroxydeoxyguanosine; 82; 82/80; Animals; Brain; Brain Ischemia - metabolism; Cell Line; Cerebral Cortex - cytology; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Cerebral infarction; Cytochrome c; Dentate gyrus; Dentate Gyrus - cytology; Dentate Gyrus - drug effects; Dentate Gyrus - metabolism; Deoxyguanosine; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - metabolism; Electron transport chain; Enzymatic activity; Gene Expression Regulation - drug effects; Glutathione; Homocysteine; Homocysteine - adverse effects; Humanities and Social Sciences; Ischemia; Janus kinase 2; Male; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - ultrastructure; Mitochondrial Proteins - metabolism; multidisciplinary; NADH-ubiquinone oxidoreductase; Neurotoxicity; Oxidative Stress; Phosphorylation; Phosphorylation - drug effects; Rats; Reactive oxygen species; Reactive Oxygen Species - metabolism; Rodents; Science; Science (multidisciplinary); Stat3 protein; STAT3 Transcription Factor - metabolism; Tyrphostins - pharmacology; Ultrastructure

Homocysteine (Hcy) has been shown to have a neurotoxic effect on ischemic brain cells; however, the underlying mechanisms remain incompletely understood. Here, we examined whether Hcy treatment influences mitochondria injury, oxidative stress, and mitochondrial STAT3 (mitoStat3) expression in rat is...