Homocysteine induces mitochondrial dysfunction involving the crosstalk between oxidative stress and mitochondrial pSTAT3 in rat ischemic brain - Chen, Shuang; Dong, Zhiping; Zhao, Yaqian; Sai, Na; Wang, Xuan; Liu, Huan; Huang, Guowei; Zhang, Xumei (Scientific reports, 2017)
Keywords: 13; 13/1; 13/51; 14/63; 38; 38/1; 631/378/1689/534; 692/617/375/534; 8-Hydroxydeoxyguanosine; 82; 82/80; Animals; Brain; Brain Ischemia - metabolism; Cell Line; Cerebral Cortex - cytology; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Cerebral infarction; Cytochrome c; Dentate gyrus; Dentate Gyrus - cytology; Dentate Gyrus - drug effects; Dentate Gyrus - metabolism; Deoxyguanosine; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - metabolism; Electron transport chain; Enzymatic activity; Gene Expression Regulation - drug effects; Glutathione; Homocysteine; Homocysteine - adverse effects; Humanities and Social Sciences; Ischemia; Janus kinase 2; Male; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - ultrastructure; Mitochondrial Proteins - metabolism; multidisciplinary; NADH-ubiquinone oxidoreductase; Neurotoxicity; Oxidative Stress; Phosphorylation; Phosphorylation - drug effects; Rats; Reactive oxygen species; Reactive Oxygen Species - metabolism; Rodents; Science; Science (multidisciplinary); Stat3 protein; STAT3 Transcription Factor - metabolism; Tyrphostins - pharmacology; Ultrastructure