Evidence of plasma biomarkers indicating high risk of dementia in cognitively normal subjects

• Published in: Scientific reports Vol. 12; no. 1; pp. 1192 - 7
• Main Authors: Pai, Ming-Chyi, Wu, Chau-Chung, Hou, Yi-Chou, Jeng, Jiann-Shing, Tang, Sung-Chun, Lin, Wei-Che, Lu, Cheng-Hsien, Chiu, Ming-Jang, Chen, Ta-Fu, Yan, Sui-Hing, Hu, Chaur-Jong, Yang, Shieh-Yueh
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.01.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378; 692/499; 692/53; 692/617; 692/699; Adult; Aged; Aged, 80 and over; Alzheimer's disease; Amyloid beta-Peptides - blood; Apnea; Biomarkers; Biomarkers - blood; Case-Control Studies; Cognition; Dementia; Dementia - blood; Dementia - etiology; Dementia disorders; Diabetes; Diabetes Complications - blood; Diabetes mellitus; End-stage renal disease; Female; Genetics; Humanities and Social Sciences; Humans; Kidney diseases; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - complications; Male; Middle Aged; multidisciplinary; Neurodegeneration; Neurodegenerative diseases; Peptide Fragments - blood; Plasma; Plasma levels; Risk Assessment; Science; Science (multidisciplinary); Sleep apnea; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - complications; Sleep disorders; Stroke; Stroke - blood; Stroke - complications; Tau protein; tau Proteins - blood

Subjects with comorbidities are at risk for neurodegeneration. There is a lack of a direct relationship between comorbidities and neurodegeneration. In this study, immunomagnetic reduction (IMR) assays were utilized to assay plasma Aβ 1–42 and total tau protein (T-Tau) levels in poststroke (PS, n = ...