Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL/6 strain

• Published in: Scientific reports Vol. 7; no. 1; pp. 3472 - 10
• Main Authors: Vandersarren, Lana, Bosteels, Cedric, Vanheerswynghels, Manon, Moon, James J., Easton, Andrew J., Van Isterdael, Gert, Janssens, Sophie, Lambrecht, Bart N., van Helden, Mary J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.06.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/106; 13/21; 13/31; 38; 38/90; 631/250/255/2514; 64/60; 692/420/2780/2152/1566/1618; Amino Acid Sequence; Amino acids; Animals; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cells, Cultured; Epitope mapping; Epitope Mapping - methods; Epitopes, T-Lymphocyte - chemistry; Epitopes, T-Lymphocyte - immunology; Female; Histocompatibility Antigens Class II - immunology; Humanities and Social Sciences; Immune clearance; Immune response (cell-mediated); Immunity, Cellular; Kinetics; Lymphocytes; Lymphocytes T; Matrix protein; Mice; Mice, Inbred C57BL; multidisciplinary; Murine pneumonia virus - immunology; Pneumonia; Pneumonia, Viral - immunology; Pneumonia, Viral - virology; Proteomes; Respiratory syncytial virus; Science; Science (multidisciplinary); T cell receptors; Transgenic mice

Pneumonia virus of mice (PVM) infection has been widely used as a rodent model to study the closely related human respiratory syncytial virus (hRSV). While T cells are indispensable for viral clearance, they also contribute to immunopathology. To gain more insight into mechanistic details, novel too...