Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28

• Published in: Nature communications Vol. 9; no. 1; pp. 1424 - 13
• Main Authors: Jiang, Yu, Liu, Ying, Lu, Huiping, Sun, Shao-Cong, Jin, Wei, Wang, Xiaohu, Dong, Chen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.04.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/31; 45; 45/15; 45/91; 631/250/1619/554/1898/1273; 631/250/2152/1566/2493; 631/250/2502/2170; 631/250/38; Animals; Autoimmune diseases; Cell activation; Cell Differentiation; Cell fate; Cytokines; Differentiation (biology); Encephalomyelitis, Autoimmune, Experimental - genetics; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - pathology; Enhancer Elements, Genetic; Enhancers; Epigenesis, Genetic; Epigenetics; Genome-Wide Association Study; Genomes; Helper cells; Hematopoiesis - genetics; Humanities and Social Sciences; Interleukin 1; Interleukin 17; Interleukin 6; Interleukin-17 - genetics; Interleukin-17 - immunology; Interleukin-6 - genetics; Interleukin-6 - immunology; Lymphocyte Activation; Lymphocytes T; Mice; Mice, Knockout; multidisciplinary; Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics; Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology; Protein Binding; Science; Science (multidisciplinary); Signal Transduction; Signaling; Stat3 protein; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - immunology; T cell receptors; Th17 Cells - immunology; Th17 Cells - pathology; Tripartite Motif-Containing Protein 28 - deficiency; Tripartite Motif-Containing Protein 28 - genetics; Tripartite Motif-Containing Protein 28 - immunology

Epigenetic regulation is important for T-cell fate decision. Although STAT3 is known to initiate Th17 differentiation program, the downstream mechanism is unclear. Here we show that Tripartite motif containing 28 ( Trim28 ) expression in Th17 cells is required for Th17-mediated cytokine production a...