Cognitive profiling and proteomic analysis of the modafinil analogue S-CE-123 in experienced aged rats

• Published in: Scientific reports Vol. 11; no. 1; p. 23962
• Main Authors: Gyertyán, István, Lubec, Jana, Ernyey, Alíz Judit, Gerner, Christopher, Kassai, Ferenc, Kalaba, Predrag, Kozma, Kata, Cobankovic, Iva, Brenner, Gábor, Wackerlig, Judith, Franschitz, Eva, Urban, Ernst, Langer, Thierry, Malikovic, Jovana, Lubec, Gert
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.12.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154/436; 631/378/1595; 631/378/1689/132; 631/45/475; Aging; Aging - metabolism; Animals; Antioxidants; Benzhydryl Compounds - pharmacology; Cognition - drug effects; Cognitive ability; Cognitive enhancement; Humanities and Social Sciences; Impulsive behavior; Learning - drug effects; Male; Modafinil; Modafinil - analogs & derivatives; Modafinil - pharmacology; Motivation; Motor skill learning; multidisciplinary; Neurodegeneration; Operant conditioning; Prefrontal cortex; Prefrontal Cortex - metabolism; Proteomics; Rats; Science; Science (multidisciplinary); Social interactions; Spatial discrimination learning; Test systems; Translation

The lack of novel cognitive enhancer drugs in the clinic highlights the prediction problems of animal assays. The objective of the current study was to test a putative cognitive enhancer in a rodent cognitive test system with improved translational validity and clinical predictivity. Cognitive profi...