Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation

• Published in: Communications chemistry Vol. 6; no. 1; p. 48
• Main Authors: Jia, Xinying, Chin, Yanni K.-Y., Zhang, Alan H., Crawford, Theo, Zhu, Yifei, Fletcher, Nicholas L., Zhou, Zihan, Hamilton, Brett R., Stroet, Martin, Thurecht, Kristofer J., Mobli, Mehdi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/45/607/1166; 631/45/611; 631/92/607/1166; 631/92/611; 82/16; 82/29; 82/58; 82/6; 82/80; 82/83; Biomolecules; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Controllability; Enzymes; Membranes; Peptides; Polymerization; Proteins; Reaction kinetics; Reaction mechanisms; Structural stability

Macrocyclisation of proteins and peptides results in a remarkable increase in structural stability, making cyclic peptides and proteins of great interest in drug discovery—either directly as drug leads or as in the case of cyclised nanodiscs (cNDs), as tools for studies of trans-membrane receptors a...