Pharmacological brain cytoprotection in acute ischaemic stroke — renewed hope in the reperfusion era

• Published in: Nature reviews. Neurology Vol. 18; no. 4; pp. 193 - 202
• Main Authors: Fisher, Marc, Savitz, Sean I.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2022; Nature Publishing Group
• Subjects: 692/617; 692/617/375/1370; Brain; Brain Ischemia - drug therapy; Cytoprotection; Drug development; Endovascular Procedures; Humans; Ischemia; Ischemic Stroke; Medicine; Medicine & Public Health; Neurology; Reperfusion; Review; Review Article; Stroke; Stroke - drug therapy; Thrombectomy; Treatment Outcome

For over 40 years, attempts to develop treatments that protect neurons and other brain cells against the cellular and biochemical consequences of cerebral ischaemia in acute ischaemic stroke (AIS) have been unsuccessful. However, the advent of intravenous thrombolysis and endovascular thrombectomy h...