Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess Glucocorticoid Exposure

• Published in: Scientific reports Vol. 9; no. 1; p. 6015
• Main Authors: Sieber-Ruckstuhl, Nadja S., Burla, Bo, Spoerel, Susanne, Schmid, Florence, Venzin, Claudio, Cazenave-Gassiot, Amaury, Bendt, Anne K., Torta, Federico, Wenk, Markus R., Boretti, Felicitas S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.04.2019; Nature Publishing Group
• Subjects: 631/45/608; 692/163/2743/2099; 692/699/2743/1279; 82/58; Adipogenesis; Animals; Arteriosclerosis; Cardiovascular diseases; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Dogs; Dyslipidemia; Environmental Exposure - adverse effects; Female; Glucocorticoids; Glucocorticoids - adverse effects; Humanities and Social Sciences; Hyperlipidemia; Hypertension; Immunosuppressive agents; Inflammation; Lipid metabolism; Lipidomics; Lipids - blood; Lipolysis; Male; Metabolic disorders; Metabolism; multidisciplinary; Phenotype; Science; Science (multidisciplinary); Time Factors

Glucocorticoids (GCs) are critical regulators of metabolic control in mammals and their aberrant function has been linked to several pathologies. GCs are widely used in human and veterinary clinical practice as potent anti-inflammatory and immune suppressive agents. Dyslipidaemia is a frequently obs...