A methanolic extract of Zanthoxylum bungeanum modulates secondary metabolism regulator genes in Aspergillus flavus and shuts down aflatoxin production

• Published in: Scientific reports Vol. 12; no. 1; p. 5995
• Main Authors: Abbas, Asmaa, Wright, Colin W., El-Sawi, Nagwa, Yli-Mattila, Tapani, Malinen, Anssi M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/193; 631/326/22/1292; 631/337/2019; Aflatoxin B1; Aflatoxin B1 - metabolism; Aflatoxins; Antioxidants; Aspergillus flavus; Aspergillus flavus - metabolism; Biosynthesis; Epicatechin; Flavonoids; Flavonoids - metabolism; Food additives; Fungicides; G protein-coupled receptors; Genes, Regulator; Humanities and Social Sciences; Kaempferol; Mass spectrometry; Mass spectroscopy; Metabolism; Metabolites; Methanol - metabolism; multidisciplinary; Phenolic compounds; Phenols; Plant Extracts - metabolism; Plant Extracts - pharmacology; Quercetin; Science; Science (multidisciplinary); Secondary Metabolism; Signal transduction; Toxins; Transcription; Zanthoxylum - genetics; Zanthoxylum bungeanum

Aflatoxin B1 (AFB1) is a food-borne toxin produced by Aspergillus flavus and a few similar fungi. Natural anti-aflatoxigenic compounds are used as alternatives to chemical fungicides to prevent AFB1 accumulation. We found that a methanolic extract of the food additive Zanthoxylum bungeanum shuts dow...