Diversity of antigenic mutants of influenza A(H1N1)pdm09 virus escaped from human monoclonal antibodies

• Published in: Scientific reports Vol. 7; no. 1; pp. 17735 - 9
• Main Authors: Yasuhara, Atsuhiro, Yamayoshi, Seiya, Soni, Priyanka, Takenaga, Toru, Kawakami, Chiharu, Takashita, Emi, Sakai-Tagawa, Yuko, Uraki, Ryuta, Ito, Mutsumi, Iwatsuki-Horimoto, Kiyoko, Sasaki, Tadahiro, Ikuta, Kazuyoshi, Yamada, Shinya, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.12.2017; Nature Publishing Group
• Subjects: 38/1; 631/250/255/1578; 631/326/596/1578; Amino Acid Sequence - genetics; Amino Acid Substitution; Amino acids; Antibodies, Monoclonal - genetics; Antibodies, Monoclonal - immunology; Antigenic drift; Antigenic Variation - genetics; Antigens, Viral - immunology; Epidemics; Genetic Variation - genetics; Glutamine; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Humanities and Social Sciences; Humans; Immunoglobulins; Influenza; Influenza A; Influenza A Virus, H1N1 Subtype - genetics; Influenza A Virus, H1N1 Subtype - immunology; Influenza, Human - virology; Lysine; Monoclonal antibodies; multidisciplinary; Mutation; Science; Science (multidisciplinary); Strains (organisms); Viruses

Since the 2017 Southern Hemisphere influenza season, the A(H1N1)pdm09-like virus recommended for use in the vaccine was changed because human, but not ferret, sera distinguish A(H1N1)pdm09 viruses isolated after 2013 from the previously circulating strains. An amino acid substitution, lysine to glut...