Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly

Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telomeres is not known. Here, we show that the microceph...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 11; no. 1; pp. 5861 - 18
Main Authors Cicconi, Alessandro, Rai, Rekha, Xiong, Xuexue, Broton, Cayla, Al-Hiyasat, Amer, Hu, Chunyi, Dong, Siying, Sun, Wenqi, Garbarino, Jennifer, Bindra, Ranjit S., Schildkraut, Carl, Chen, Yong, Chang, Sandy
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 17.11.2020
Nature Publishing Group
Nature Portfolio
Subjects
13/89
631/337
631/337/103/560
631/378
64/60
Aminopeptidases - genetics
Aminopeptidases - metabolism
Animals
Binding Sites
Calorimetry
Cell Cycle Proteins - chemistry
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Chromosomes
Crystal defects
Crystal structure
Cytoskeletal Proteins - chemistry
Cytoskeletal Proteins - genetics
Cytoskeletal Proteins - metabolism
Damage localization
Deoxyribonucleic acid
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - metabolism
Disorders
DNA
DNA Damage
DNA repair
Fibroblasts
HeLa Cells
Histones - genetics
Histones - metabolism
Homology
Humanities and Social Sciences
Humans
Localization
Mice
Microcephaly
Microcephaly - genetics
Microencephaly
multidisciplinary
Mutation
Protein Interaction Domains and Motifs
Protein structure
Proteins
Repair
Replication
Replication forks
Science
Science (multidisciplinary)
Serine Proteases - genetics
Serine Proteases - metabolism
Shelterin Complex
Telomerase
Telomerase reverse transcriptase
Telomere - genetics
Telomere - metabolism
Telomere-binding protein
Telomere-Binding Proteins - genetics
Telomere-Binding Proteins - metabolism
Telomeres
Telomeric Repeat Binding Protein 2 - chemistry
Telomeric Repeat Binding Protein 2 - genetics
Telomeric Repeat Binding Protein 2 - metabolism
TRF2 protein
Yeast
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-020-19674-0

Cover

Abstract Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telomeres is not known. Here, we show that the microcephalin 1/BRCT-repeats inhibitor of hTERT (MCPH1/BRIT1) protein, mutated in primary microcephaly, specifically interacts with the TRFH domain of the telomere binding protein TRF2. The crystal structure of the MCPH1–TRF2 complex reveals that this interaction is mediated by the MCPH1 330 YRLSP 334 motif. TRF2-dependent recruitment of MCPH1 promotes localization of DNA damage factors and homology directed repair of dysfunctional telomeres lacking POT1-TPP1. Additionally, MCPH1 is involved in the replication stress response, promoting telomere replication fork progression and restart of stalled telomere replication forks. Our work uncovers a previously unrecognized role for MCPH1 in promoting telomere replication, providing evidence that telomere replication defects may contribute to the onset of microcephaly. Primary microcephaly is a clinical feature of several human telomere disorder syndromes. Here the authors reveal a role of Microcephalin 1 in promoting telomere replication and repair.
AbstractList Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telomeres is not known. Here, we show that the microcephalin 1/BRCT-repeats inhibitor of hTERT (MCPH1/BRIT1) protein, mutated in primary microcephaly, specifically interacts with the TRFH domain of the telomere binding protein TRF2. The crystal structure of the MCPH1-TRF2 complex reveals that this interaction is mediated by the MCPH1 330YRLSP334 motif. TRF2-dependent recruitment of MCPH1 promotes localization of DNA damage factors and homology directed repair of dysfunctional telomeres lacking POT1-TPP1. Additionally, MCPH1 is involved in the replication stress response, promoting telomere replication fork progression and restart of stalled telomere replication forks. Our work uncovers a previously unrecognized role for MCPH1 in promoting telomere replication, providing evidence that telomere replication defects may contribute to the onset of microcephaly.Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telomeres is not known. Here, we show that the microcephalin 1/BRCT-repeats inhibitor of hTERT (MCPH1/BRIT1) protein, mutated in primary microcephaly, specifically interacts with the TRFH domain of the telomere binding protein TRF2. The crystal structure of the MCPH1-TRF2 complex reveals that this interaction is mediated by the MCPH1 330YRLSP334 motif. TRF2-dependent recruitment of MCPH1 promotes localization of DNA damage factors and homology directed repair of dysfunctional telomeres lacking POT1-TPP1. Additionally, MCPH1 is involved in the replication stress response, promoting telomere replication fork progression and restart of stalled telomere replication forks. Our work uncovers a previously unrecognized role for MCPH1 in promoting telomere replication, providing evidence that telomere replication defects may contribute to the onset of microcephaly.
Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telomeres is not known. Here, we show that the microcephalin 1/BRCT-repeats inhibitor of hTERT (MCPH1/BRIT1) protein, mutated in primary microcephaly, specifically interacts with the TRFH domain of the telomere binding protein TRF2. The crystal structure of the MCPH1-TRF2 complex reveals that this interaction is mediated by the MCPH1 YRLSP motif. TRF2-dependent recruitment of MCPH1 promotes localization of DNA damage factors and homology directed repair of dysfunctional telomeres lacking POT1-TPP1. Additionally, MCPH1 is involved in the replication stress response, promoting telomere replication fork progression and restart of stalled telomere replication forks. Our work uncovers a previously unrecognized role for MCPH1 in promoting telomere replication, providing evidence that telomere replication defects may contribute to the onset of microcephaly.
Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telomeres is not known. Here, we show that the microcephalin 1/BRCT-repeats inhibitor of hTERT (MCPH1/BRIT1) protein, mutated in primary microcephaly, specifically interacts with the TRFH domain of the telomere binding protein TRF2. The crystal structure of the MCPH1–TRF2 complex reveals that this interaction is mediated by the MCPH1 330YRLSP334 motif. TRF2-dependent recruitment of MCPH1 promotes localization of DNA damage factors and homology directed repair of dysfunctional telomeres lacking POT1-TPP1. Additionally, MCPH1 is involved in the replication stress response, promoting telomere replication fork progression and restart of stalled telomere replication forks. Our work uncovers a previously unrecognized role for MCPH1 in promoting telomere replication, providing evidence that telomere replication defects may contribute to the onset of microcephaly.Primary microcephaly is a clinical feature of several human telomere disorder syndromes. Here the authors reveal a role of Microcephalin 1 in promoting telomere replication and repair.
Primary microcephaly is a clinical feature of several human telomere disorder syndromes. Here the authors reveal a role of Microcephalin 1 in promoting telomere replication and repair.
Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telomeres is not known. Here, we show that the microcephalin 1/BRCT-repeats inhibitor of hTERT (MCPH1/BRIT1) protein, mutated in primary microcephaly, specifically interacts with the TRFH domain of the telomere binding protein TRF2. The crystal structure of the MCPH1–TRF2 complex reveals that this interaction is mediated by the MCPH1 330 YRLSP 334 motif. TRF2-dependent recruitment of MCPH1 promotes localization of DNA damage factors and homology directed repair of dysfunctional telomeres lacking POT1-TPP1. Additionally, MCPH1 is involved in the replication stress response, promoting telomere replication fork progression and restart of stalled telomere replication forks. Our work uncovers a previously unrecognized role for MCPH1 in promoting telomere replication, providing evidence that telomere replication defects may contribute to the onset of microcephaly. Primary microcephaly is a clinical feature of several human telomere disorder syndromes. Here the authors reveal a role of Microcephalin 1 in promoting telomere replication and repair.
Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telomeres is not known. Here, we show that the microcephalin 1/BRCT-repeats inhibitor of hTERT (MCPH1/BRIT1) protein, mutated in primary microcephaly, specifically interacts with the TRFH domain of the telomere binding protein TRF2. The crystal structure of the MCPH1–TRF2 complex reveals that this interaction is mediated by the MCPH1 330 YRLSP 334 motif. TRF2-dependent recruitment of MCPH1 promotes localization of DNA damage factors and homology directed repair of dysfunctional telomeres lacking POT1-TPP1. Additionally, MCPH1 is involved in the replication stress response, promoting telomere replication fork progression and restart of stalled telomere replication forks. Our work uncovers a previously unrecognized role for MCPH1 in promoting telomere replication, providing evidence that telomere replication defects may contribute to the onset of microcephaly.
ArticleNumber 5861
Author Hu, Chunyi
Broton, Cayla
Chang, Sandy
Xiong, Xuexue
Sun, Wenqi
Cicconi, Alessandro
Rai, Rekha
Schildkraut, Carl
Dong, Siying
Al-Hiyasat, Amer
Garbarino, Jennifer
Bindra, Ranjit S.
Chen, Yong
Author_xml – sequence: 1
  givenname: Alessandro
  orcidid: 0000-0001-8248-3568
  surname: Cicconi
  fullname: Cicconi, Alessandro
  organization: Department of Laboratory Medicine, Yale University School of Medicine
– sequence: 2
  givenname: Rekha
  surname: Rai
  fullname: Rai, Rekha
  organization: Department of Laboratory Medicine, Yale University School of Medicine
– sequence: 3
  givenname: Xuexue
  surname: Xiong
  fullname: Xiong, Xuexue
  organization: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
– sequence: 4
  givenname: Cayla
  orcidid: 0000-0001-6651-8724
  surname: Broton
  fullname: Broton, Cayla
  organization: Department of Laboratory Medicine, Yale University School of Medicine, Tri- Institutional MD/PhD Program, Weill Cornell Medical College
– sequence: 5
  givenname: Amer
  surname: Al-Hiyasat
  fullname: Al-Hiyasat, Amer
  organization: Department of Laboratory Medicine, Yale University School of Medicine, Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine
– sequence: 6
  givenname: Chunyi
  surname: Hu
  fullname: Hu, Chunyi
  organization: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
– sequence: 7
  givenname: Siying
  surname: Dong
  fullname: Dong, Siying
  organization: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
– sequence: 8
  givenname: Wenqi
  surname: Sun
  fullname: Sun, Wenqi
  organization: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
– sequence: 9
  givenname: Jennifer
  surname: Garbarino
  fullname: Garbarino, Jennifer
  organization: Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, Department of Therapeutic Radiology, Yale University School of Medicine
– sequence: 10
  givenname: Ranjit S.
  orcidid: 0000-0002-3255-0467
  surname: Bindra
  fullname: Bindra, Ranjit S.
  organization: Department of Therapeutic Radiology, Yale University School of Medicine, Department of Experimental Pathology, Yale University School of Medicine
– sequence: 11
  givenname: Carl
  surname: Schildkraut
  fullname: Schildkraut, Carl
  organization: Department of Cell Biology, Albert Einstein College of Medicine
– sequence: 12
  givenname: Yong
  orcidid: 0000-0001-5857-6086
  surname: Chen
  fullname: Chen, Yong
  email: yongchen@sibcb.ac.cn
  organization: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
– sequence: 13
  givenname: Sandy
  orcidid: 0000-0002-9560-1671
  surname: Chang
  fullname: Chang, Sandy
  email: s.chang@yale.edu
  organization: Department of Laboratory Medicine, Yale University School of Medicine, Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, Department of Pathology, Yale University School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33203878$$D View this record in MEDLINE/PubMed
BookMark eNp9kstu1DAYhSNUREvpC7BAkdiwINS3-LJBgorCSEVI1bC2HOfP1ENiD3aCNA_Ae-NOpkzbRb3x7ZzPx_b_sjjywUNRvMboA0ZUnieGGRcVIqjCigtWoWfFCUEMV1gQenRvfFycpbRGuVGFJWMvimNKSWYIeVL8_e5sDBY2N6Z3vsTnn68XS1wtry9J6fwI0djRBV9uYhjCCKkcoQ8DRCgjbHpnzW7X-PZ2blx8X2bML-dXB2G7Td3kZ8wYMskNJm7L4XDw9lXxvDN9grN9f1r8vPyyvPhWXf34urj4dFXZmqGxYrkznFsl8l1YLVmHFW6UkmAVzxdSVEhL2raWoDoL1CLERCOIrQFUg4CeFouZ2waz1vskOhindwshrrSJo7M9aNx1ICi3FgywhhsFLXCDW0yRamqgmfVxZm2mZoDWgh-j6R9AH-54d6NX4Y8WXBAk6gx4twfE8HuCNOrBJQt9bzyEKWnCOJacMCqz9O0j6TpM0eenyiqBa4FJLbLqzf1E_6Pc_XYWyFmQXz6lCJ22btz9YA7oeo2Rvq0tPdeWzrWld7WlUbaSR9Y7-pMmOptSFvsVxEPsJ1z_AKh24w4
CitedBy_id crossref_primary_10_3390_brainsci11050581
crossref_primary_10_3390_molecules27248790
crossref_primary_10_3389_fgene_2021_638790
crossref_primary_10_1038_s42003_024_06263_w
crossref_primary_10_18699_vjgb_24_55
crossref_primary_10_3390_genes13040634
crossref_primary_10_3390_cells10071753
crossref_primary_10_1016_j_ajhg_2021_08_009
crossref_primary_10_1371_journal_pgen_1011515
crossref_primary_10_3389_fcell_2021_729265
crossref_primary_10_3390_cells12040642
crossref_primary_10_3390_cells13221896
crossref_primary_10_3390_cells11020275
crossref_primary_10_1016_j_cels_2024_05_006
crossref_primary_10_7554_eLife_73348
crossref_primary_10_3389_fonc_2023_1047588
Cites_doi 10.1016/S0092-8674(00)81174-5
10.1016/j.dnarep.2013.04.017
10.1038/cr.2017.144
10.1146/annurev.bi.65.070196.002005
10.1016/j.celrep.2016.04.047
10.1016/j.gene.2011.12.053
10.1111/j.1471-4159.2006.03779.x
10.1016/j.cell.2007.12.033
10.1371/journal.pgen.1000826
10.1038/nature03445
10.1074/jbc.M705245200
10.1016/j.molcel.2018.03.036
10.1016/j.molcel.2018.08.016
10.1038/ncb1895
10.1107/S0907444902016657
10.1016/j.celrep.2019.11.012
10.1016/j.molcel.2014.12.024
10.1016/j.celrep.2013.07.033
10.1126/science.1064603
10.1101/gr.219899.116
10.1073/pnas.0507722102
10.1016/j.molcel.2010.01.021
10.1038/onc.2016.405
10.1016/j.celrep.2013.08.017
10.1016/j.gde.2020.02.016
10.1038/ncb1275
10.1016/j.molcel.2017.09.036
10.4161/cc.9.24.14157
10.1086/422855
10.1038/emboj.2010.142
10.1016/j.celrep.2016.05.008
10.4161/cc.20810
10.1038/nn.3097
10.1016/j.celrep.2014.07.036
10.1038/onc.2014.367
10.1126/science.1218498
10.1146/annurev-genet-032918-021921
10.1016/S0092-8674(00)80932-0
10.1038/ng.810
10.1016/j.molcel.2017.01.016
10.1136/jmg.2009.076398
10.1038/nature08196
10.1038/nsmb.1575
10.1073/pnas.1708211114
10.1371/journal.pone.0040387
10.1038/ng1129
10.1038/nsmb.1974
10.1101/gad.251611.114
10.1016/j.cell.2006.05.037
10.1101/gad.1839909
10.1016/j.cell.2011.03.041
10.1093/carcin/bgp268
10.1016/j.cell.2009.06.021
10.1016/j.molcel.2018.09.014
10.1083/jcb.201809012
10.1371/journal.pone.0058156
10.1074/jbc.M114.587113
10.1107/S0021889807021206
10.1186/s13742-015-0107-0
10.1038/nature18003
10.1016/S0960-9822(03)00542-6
10.1107/S0907444904019158
10.1016/j.ajhg.2015.02.017
10.1016/S0092-8674(03)00430-6
10.1007/s00412-015-0512-2
10.1111/bjh.13442
10.1083/jcb.201106141
10.1038/sj.emboj.7601893
10.1016/j.ejmg.2013.09.007
10.1038/emboj.2010.58
10.1136/jmg.40.6.385
10.3892/ol.2015.3857
10.1038/ng.3790
10.3390/genes8020055
10.1126/science.1151804
10.1086/301966
10.1073/pnas.0602436103
10.1242/dev.01215
10.1038/nature03443
10.1523/JNEUROSCI.4245-13.2014
10.1038/nmeth.3047
10.1101/gad.295402.116
10.1146/annurev-genom-083117-021441
10.1016/j.ccr.2006.07.002
10.1038/nsmb.1710
10.1038/ncb1431
10.1016/j.molcel.2015.12.009
10.1038/nature01385
10.1016/j.gene.2015.07.058
10.1016/j.cell.2012.05.026
10.1016/S0076-6879(97)76066-X
10.4161/cc.7.14.6303
10.1016/j.cell.2012.03.030
10.1371/journal.pone.0009242
10.1016/j.celrep.2020.03.070
10.1016/j.cell.2010.05.032
10.1101/gad.248567.114
10.1016/j.ceb.2005.11.004
10.1073/pnas.1510750112
10.1086/341283
10.1038/ncb2342
10.1126/science.297.5581.565
10.1038/nature18325
10.1073/pnas.0805139105
10.1126/science.1062560
10.1016/j.molcel.2010.06.031
ContentType Journal Article
Copyright The Author(s) 2020
The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2020
– notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-020-19674-0
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
Health & Medical Collection (Alumni Edition)
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
Publicly Available Content Database


CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 18
ExternalDocumentID oai_doaj_org_article_1ffe736cceae4b6a9ede6a1d1309b5e3
PMC7672075
33203878
10_1038_s41467_020_19674_0
Genre Research Support, U.S. Gov't, Non-P.H.S
Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: United States Department of Defense | United States Army | Army Medical Command | United States Army Institute of Surgical Research | U.S. Army Dental and Trauma Research Detachment (Army Dental and Trauma Research Detachment)
  grantid: W81XWH191005
  funderid: https://doi.org/10.13039/100010462
– fundername: NCATS NIH HHS
  grantid: UL1 TR001863
– fundername: NCI NIH HHS
  grantid: T32 CA193200
– fundername: NIGMS NIH HHS
  grantid: R01 GM045751
– fundername: ;
  grantid: W81XWH191005
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
RC3
SOI
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c540t-4c54a66c970034584f191b998ec960389378c2dd58e9fce3c0047b72c5ee9b0e3
IEDL.DBID DOA
ISSN 2041-1723
IngestDate Wed Aug 27 01:29:59 EDT 2025
Thu Aug 21 14:08:22 EDT 2025
Fri Jul 11 01:06:14 EDT 2025
Wed Aug 13 08:04:47 EDT 2025
Thu Apr 03 06:57:20 EDT 2025
Tue Jul 01 04:09:08 EDT 2025
Thu Apr 24 23:08:45 EDT 2025
Fri Feb 21 02:40:03 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-4c54a66c970034584f191b998ec960389378c2dd58e9fce3c0047b72c5ee9b0e3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0001-8248-3568
0000-0002-9560-1671
0000-0002-3255-0467
0000-0001-6651-8724
0000-0001-5857-6086
OpenAccessLink https://doaj.org/article/1ffe736cceae4b6a9ede6a1d1309b5e3
PMID 33203878
PQID 2471571257
PQPubID 546298
PageCount 18
ParticipantIDs doaj_primary_oai_doaj_org_article_1ffe736cceae4b6a9ede6a1d1309b5e3
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7672075
proquest_miscellaneous_2461862438
proquest_journals_2471571257
pubmed_primary_33203878
crossref_citationtrail_10_1038_s41467_020_19674_0
crossref_primary_10_1038_s41467_020_19674_0
springer_journals_10_1038_s41467_020_19674_0
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-11-17
PublicationDateYYYYMMDD 2020-11-17
PublicationDate_xml – month: 11
  year: 2020
  text: 2020-11-17
  day: 17
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2020
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References McCoy (CR104) 2007; 40
Alderton (CR19) 2006; 8
Dephoure (CR73) 2008; 105
Greider (CR28) 1996; 65
Cicconi, Chang (CR80) 2020; 60
Rai (CR16) 2006; 10
Wan (CR44) 2013; 4
Billing (CR63) 2018; 72
Taglialatela (CR62) 2017; 68
Rickman, Smogorzewska (CR64) 2019; 218
Sfeir, de Lange (CR41) 2012; 336
Cheng (CR70) 2016; 5
Adams (CR105) 2002; 58
Rai (CR22) 2008; 7
Orii, Lee, Kondo, McKinnon (CR92) 2006; 103
Wu, Takai, de Lange (CR83) 2012; 150
Yen (CR21) 2017; 114
Maestroni, Matmati, Coulon (CR66) 2017; 8
Rai (CR45) 2017; 65
Norio, Schildkraut (CR55) 2001; 294
Liang (CR26) 2015; 34
Chen (CR43) 2008; 319
Jackson (CR8) 2002; 71
Kocak (CR97) 2014; 28
Darvish (CR11) 2010; 47
van Steensel, Smogorzewska, de Lange (CR48) 1998; 92
Varon (CR4) 1998; 93
Trimborn (CR24) 2004; 75
Ye (CR84) 2010; 142
Jayaraman, Bae, Walsh (CR1) 2018; 19
Lin, Elledge (CR9) 2003; 113
Bansbach, Betous, Lovejoy, Glick, Cortez (CR60) 2009; 23
Schlacher (CR56) 2011; 145
Wilson (CR72) 2013; 4
Farmer (CR67) 2005; 434
Rai, Chen, Lei, Chang (CR39) 2016; 7
Yamashita (CR25) 2011; 194
Otwinowski, Minor (CR103) 1997; 276
de Lange (CR30) 2018; 52
Bond, Woods (CR2) 2006; 18
Evrony (CR6) 2017; 27
Huertas (CR50) 2010; 17
Wei (CR71) 2011; 43
Gruber (CR88) 2011; 13
Jackson (CR7) 1998; 63
Lee, Brown, Chang, McKinnon (CR101) 2014; 34
Sakaue-Sawano (CR54) 2008; 132
Benarroch-Popivker (CR85) 2016; 61
Chen (CR91) 2013; 8
Wu (CR108) 2006; 126
Maser, DePinho (CR34) 2002; 297
Gavvovidis (CR23) 2010; 9
Mertins (CR75) 2016; 534
Poole (CR61) 2015; 112
Sfeir (CR52) 2009; 138
Wu, van Overbeek, Rooney, de Lange (CR81) 2010; 39
Wood, Singh, Mer, Chen (CR18) 2007; 282
Pinzaru (CR94) 2016; 15
Emsley, Cowtan (CR106) 2004; 60
Lee (CR93) 2012; 15
Arroyo (CR47) 2015; 124
Trimborn (CR87) 2010; 5
Mendez-Bermudez (CR86) 2018; 70
Przetocka (CR58) 2018; 72
Bailey, Cornforth, Kurimasa, Chen, Goodwin (CR51) 2001; 293
Gavvovidis (CR46) 2012; 7
Boeing (CR76) 2016; 15
Pfau (CR12) 2013; 56
Peng (CR17) 2009; 11
Shi, Li, Su (CR10) 2012; 495
Petermann, Orta, Issaeva, Schultz, Helleday (CR65) 2010; 37
Ghafouri-Fard, Fardaei, Gholami, Miryounesi (CR13) 2015; 571
Leman (CR79) 2012; 11
Vannier, Pavicic-Kaltenbrunner, Petalcorin, Ding, Boulton (CR78) 2012; 149
Journiac (CR90) 2020; 31
Lam (CR82) 2010; 29
Lin, Rai, Li, Xu, Elledge (CR15) 2005; 102
Zhang (CR69) 2015; 96
Sharma (CR74) 2014; 8
Artandi, DePinho (CR29) 2010; 31
Zhou (CR89) 2013; 12
Lobanova (CR102) 2017; 31
Zhou (CR27) 2016; 11
Celli, de Lange (CR37) 2005; 7
De Vries, Winter, Schinzel, van Ravenswaaij-Arts (CR95) 2003; 40
Reynolds (CR5) 2017; 49
Zimmermann, Kibe, Kabir, de Lange (CR59) 2014; 28
Deng, Guo, Ferguson, Chang (CR33) 2009; 460
Sanjana, Shalem, Zhang (CR107) 2014; 11
Hu (CR31) 2017; 27
Liang (CR20) 2010; 6
Kim (CR42) 2009; 16
Takai, Smogorzewska, de Lange (CR49) 2003; 13
Rai (CR36) 2010; 29
Chen (CR38) 2011; 18
Sarek, Vannier, Panier, Petrini, Boulton (CR77) 2015; 57
Zhang (CR100) 2006; 97
Gu (CR35) 2017; 36
Ferron (CR99) 2004; 131
Ray Chaudhuri (CR57) 2016; 535
Bryant (CR68) 2005; 434
Rai (CR40) 2019; 29
Guo (CR32) 2007; 26
Zhang (CR53) 2014; 289
O’Driscoll, Ruiz-Perez, Woods, Jeggo, Goodship (CR3) 2003; 33
Wong (CR98) 2003; 421
Glousker, Touzot, Revy, Tzfati, Savage (CR96) 2015; 170
Naseer (CR14) 2018; 23
N Journiac (19674_CR90) 2020; 31
K Schlacher (19674_CR56) 2011; 145
HE Bryant (19674_CR68) 2005; 434
Y Deng (19674_CR33) 2009; 460
R Rai (19674_CR36) 2010; 29
JS Wilson (19674_CR72) 2013; 4
M O’Driscoll (19674_CR3) 2003; 33
H Takai (19674_CR49) 2003; 13
J Chen (19674_CR91) 2013; 8
AM Pinzaru (19674_CR94) 2016; 15
D Benarroch-Popivker (19674_CR85) 2016; 61
LA Poole (19674_CR61) 2015; 112
S Boeing (19674_CR76) 2016; 15
S Ferron (19674_CR99) 2004; 131
M Trimborn (19674_CR87) 2010; 5
JL Wood (19674_CR18) 2007; 282
M Arroyo (19674_CR47) 2015; 124
L Shi (19674_CR10) 2012; 495
PD Adams (19674_CR105) 2002; 58
B van Steensel (19674_CR48) 1998; 92
B Zhang (19674_CR53) 2014; 289
A Sfeir (19674_CR52) 2009; 138
BB De Vries (19674_CR95) 2003; 40
P Gu (19674_CR35) 2017; 36
A Mendez-Bermudez (19674_CR86) 2018; 70
D Yamashita (19674_CR25) 2011; 194
A Taglialatela (19674_CR62) 2017; 68
A Lobanova (19674_CR102) 2017; 31
YC Lam (19674_CR82) 2010; 29
R Rai (19674_CR22) 2008; 7
X Guo (19674_CR32) 2007; 26
GD Evrony (19674_CR6) 2017; 27
T de Lange (19674_CR30) 2018; 52
R Rai (19674_CR16) 2006; 10
Y Chen (19674_CR38) 2011; 18
CE Bansbach (19674_CR60) 2009; 23
X Wei (19674_CR71) 2011; 43
P Wu (19674_CR81) 2010; 39
G Glousker (19674_CR96) 2015; 170
AP Jackson (19674_CR8) 2002; 71
G Sarek (19674_CR77) 2015; 57
Y Liang (19674_CR20) 2010; 6
MI Naseer (19674_CR14) 2018; 23
D Billing (19674_CR63) 2018; 72
D Jayaraman (19674_CR1) 2018; 19
C Hu (19674_CR31) 2017; 27
P Emsley (19674_CR106) 2004; 60
GB Celli (19674_CR37) 2005; 7
Y Chen (19674_CR43) 2008; 319
P Mertins (19674_CR75) 2016; 534
A Cicconi (19674_CR80) 2020; 60
H Farmer (19674_CR67) 2005; 434
AP Jackson (19674_CR7) 1998; 63
GK Alderton (19674_CR19) 2006; 8
H Kim (19674_CR42) 2009; 16
JJ Reynolds (19674_CR5) 2017; 49
N Dephoure (19674_CR73) 2008; 105
R Rai (19674_CR45) 2017; 65
AR Leman (19674_CR79) 2012; 11
SY Lin (19674_CR9) 2003; 113
RB Pfau (19674_CR12) 2013; 56
R Rai (19674_CR40) 2019; 29
AJ McCoy (19674_CR104) 2007; 40
NE Sanjana (19674_CR107) 2014; 11
L Zhang (19674_CR69) 2015; 96
P Wu (19674_CR83) 2012; 150
J Bond (19674_CR2) 2006; 18
CW Greider (19674_CR28) 1996; 65
P Norio (19674_CR55) 2001; 294
J Ye (19674_CR84) 2010; 142
S Ghafouri-Fard (19674_CR13) 2015; 571
L Zhou (19674_CR27) 2016; 11
Y Lee (19674_CR93) 2012; 15
A Sakaue-Sawano (19674_CR54) 2008; 132
E Petermann (19674_CR65) 2010; 37
C Cheng (19674_CR70) 2016; 5
G Peng (19674_CR17) 2009; 11
KK Wong (19674_CR98) 2003; 421
I Gavvovidis (19674_CR23) 2010; 9
SE Artandi (19674_CR29) 2010; 31
R Gruber (19674_CR88) 2011; 13
WF Yen (19674_CR21) 2017; 114
S Przetocka (19674_CR58) 2018; 72
L Maestroni (19674_CR66) 2017; 8
R Varon (19674_CR4) 1998; 93
KE Orii (19674_CR92) 2006; 103
K Sharma (19674_CR74) 2014; 8
A Ray Chaudhuri (19674_CR57) 2016; 535
P Zhang (19674_CR100) 2006; 97
JB Vannier (19674_CR78) 2012; 149
B Wan (19674_CR44) 2013; 4
K Rickman (19674_CR64) 2019; 218
Y Lee (19674_CR101) 2014; 34
M Trimborn (19674_CR24) 2004; 75
I Gavvovidis (19674_CR46) 2012; 7
SM Bailey (19674_CR51) 2001; 293
L Wu (19674_CR108) 2006; 126
R Rai (19674_CR39) 2016; 7
ZW Zhou (19674_CR89) 2013; 12
SY Lin (19674_CR15) 2005; 102
M Zimmermann (19674_CR59) 2014; 28
H Darvish (19674_CR11) 2010; 47
Z Otwinowski (19674_CR103) 1997; 276
H Kocak (19674_CR97) 2014; 28
RS Maser (19674_CR34) 2002; 297
P Huertas (19674_CR50) 2010; 17
A Sfeir (19674_CR41) 2012; 336
Y Liang (19674_CR26) 2015; 34
References_xml – volume: 8
  start-page: 55
  year: 2017
  ident: CR66
  article-title: Solving the telomere replication problem
  publication-title: Genes (Basel)
– volume: 276
  start-page: 307
  year: 1997
  end-page: 326
  ident: CR103
  article-title: Processing of X-ray diffraction data collected in oscillation mode
  publication-title: Methods Enzymol.
– volume: 571
  start-page: 149
  year: 2015
  end-page: 150
  ident: CR13
  article-title: A case report: autosomal recessive microcephaly caused by a novel mutation in MCPH1 gene
  publication-title: Gene
– volume: 103
  start-page: 10017
  year: 2006
  end-page: 10022
  ident: CR92
  article-title: Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 36
  start-page: 1939
  year: 2017
  end-page: 1951
  ident: CR35
  article-title: Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis
  publication-title: Oncogene
– volume: 31
  start-page: 639
  year: 2017
  end-page: 647
  ident: CR102
  article-title: Different requirements of functional telomeres in neural stem cells and terminally differentiated neurons
  publication-title: Genes Dev.
– volume: 23
  start-page: 2405
  year: 2009
  end-page: 2414
  ident: CR60
  article-title: The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks
  publication-title: Genes Dev.
– volume: 27
  start-page: 1323
  year: 2017
  end-page: 1335
  ident: CR6
  article-title: Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome
  publication-title: Genome Res
– volume: 132
  start-page: 487
  year: 2008
  end-page: 498
  ident: CR54
  article-title: Visualizing spatiotemporal dynamics of multicellular cell-cycle progression
  publication-title: Cell
– volume: 37
  start-page: 492
  year: 2010
  end-page: 502
  ident: CR65
  article-title: Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair
  publication-title: Mol. Cell
– volume: 92
  start-page: 401
  year: 1998
  end-page: 413
  ident: CR48
  article-title: TRF2 protects human telomeres from end-to-end fusions
  publication-title: Cell
– volume: 28
  start-page: 2477
  year: 2014
  end-page: 2491
  ident: CR59
  article-title: TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling
  publication-title: Genes Dev.
– volume: 40
  start-page: 385
  year: 2003
  end-page: 398
  ident: CR95
  article-title: Telomeres: a diagnosis at the end of the chromosomes
  publication-title: J. Med. Genet
– volume: 29
  start-page: 2598
  year: 2010
  end-page: 2610
  ident: CR36
  article-title: The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres
  publication-title: EMBO J.
– volume: 124
  start-page: 491
  year: 2015
  end-page: 501
  ident: CR47
  article-title: Chromosome structure deficiencies in MCPH1 syndrome
  publication-title: Chromosoma
– volume: 18
  start-page: 213
  year: 2011
  end-page: 221
  ident: CR38
  article-title: A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms
  publication-title: Nat. Struct. Mol. Biol.
– volume: 194
  start-page: 841
  year: 2011
  end-page: 854
  ident: CR25
  article-title: MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II
  publication-title: J. Cell Biol.
– volume: 6
  start-page: e1000826
  year: 2010
  ident: CR20
  article-title: BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice
  publication-title: PLoS Genet
– volume: 289
  start-page: 34284
  year: 2014
  end-page: 34295
  ident: CR53
  article-title: Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling
  publication-title: J. Biol. Chem.
– volume: 7
  start-page: e40387
  year: 2012
  ident: CR46
  article-title: A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells
  publication-title: PLoS ONE
– volume: 17
  start-page: 11
  year: 2010
  end-page: 16
  ident: CR50
  article-title: DNA resection in eukaryotes: deciding how to fix the break
  publication-title: Nat. Struct. Mol. Biol.
– volume: 39
  start-page: 606
  year: 2010
  end-page: 617
  ident: CR81
  article-title: Apollo contributes to G overhang maintenance and protects leading-end telomeres
  publication-title: Mol. Cell
– volume: 75
  start-page: 261
  year: 2004
  end-page: 266
  ident: CR24
  article-title: Mutations in microcephalin cause aberrant regulation of chromosome condensation
  publication-title: Am. J. Hum. Genet
– volume: 102
  start-page: 15105
  year: 2005
  end-page: 15109
  ident: CR15
  article-title: BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 8
  start-page: 725
  year: 2006
  end-page: 733
  ident: CR19
  article-title: Regulation of mitotic entry by microcephalin and its overlap with ATR signalling
  publication-title: Nat. Cell Biol.
– volume: 4
  start-page: 853
  year: 2013
  end-page: 860
  ident: CR72
  article-title: Localization-dependent and -independent roles of SLX4 in regulating telomeres
  publication-title: Cell Rep.
– volume: 8
  start-page: 1583
  year: 2014
  end-page: 1594
  ident: CR74
  article-title: Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling
  publication-title: Cell Rep.
– volume: 68
  start-page: 414
  year: 2017
  end-page: 430
  ident: CR62
  article-title: Restoration of replication fork stability in BRCA1- and BRCA2-deficient cells by inactivation of SNF2-family fork remodelers
  publication-title: Mol. Cell
– volume: 47
  start-page: 823
  year: 2010
  end-page: 828
  ident: CR11
  article-title: A clinical and molecular genetic study of 112 Iranian families with primary microcephaly
  publication-title: J. Med. Genet
– volume: 60
  start-page: 77
  year: 2020
  end-page: 84
  ident: CR80
  article-title: Shelterin and the replisome: at the intersection of telomere repair and replication
  publication-title: Curr. Opin. Genet Dev.
– volume: 142
  start-page: 230
  year: 2010
  end-page: 242
  ident: CR84
  article-title: TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage
  publication-title: Cell
– volume: 336
  start-page: 593
  year: 2012
  end-page: 597
  ident: CR41
  article-title: Removal of shelterin reveals the telomere end-protection problem
  publication-title: Science
– volume: 15
  start-page: 819
  year: 2012
  end-page: 826
  ident: CR93
  article-title: Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors
  publication-title: Nat. Neurosci.
– volume: 16
  start-page: 372
  year: 2009
  end-page: 379
  ident: CR42
  article-title: TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs
  publication-title: Nat. Struct. Mol. Biol.
– volume: 534
  start-page: 55
  year: 2016
  end-page: 62
  ident: CR75
  article-title: Proteogenomics connects somatic mutations to signalling in breast cancer
  publication-title: Nature
– volume: 297
  start-page: 565
  year: 2002
  end-page: 569
  ident: CR34
  article-title: Connecting chromosomes, crisis, and cancer
  publication-title: Science
– volume: 13
  start-page: 1549
  year: 2003
  end-page: 1556
  ident: CR49
  article-title: DNA damage foci at dysfunctional telomeres
  publication-title: Curr. Biol.
– volume: 138
  start-page: 90
  year: 2009
  end-page: 103
  ident: CR52
  article-title: Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication
  publication-title: Cell
– volume: 8
  start-page: e58156
  year: 2013
  ident: CR91
  article-title: Mcph1-deficient mice reveal a role for MCPH1 in otitis media
  publication-title: PLoS ONE
– volume: 9
  start-page: 4893
  year: 2010
  end-page: 4899
  ident: CR23
  article-title: MCPH1 patient cells exhibit delayed release from DNA damage-induced G2/M checkpoint arrest
  publication-title: Cell Cycle
– volume: 4
  start-page: 861
  year: 2013
  end-page: 869
  ident: CR44
  article-title: SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres
  publication-title: Cell Rep.
– volume: 43
  start-page: 442
  year: 2011
  end-page: 446
  ident: CR71
  article-title: Exome sequencing identifies GRIN2A as frequently mutated in melanoma
  publication-title: Nat. Genet.
– volume: 11
  start-page: 783
  year: 2014
  end-page: 784
  ident: CR107
  article-title: Improved vectors and genome-wide libraries for CRISPR screening
  publication-title: Nat. Methods
– volume: 31
  start-page: 9
  year: 2010
  end-page: 18
  ident: CR29
  article-title: Telomeres and telomerase in cancer
  publication-title: Carcinogenesis
– volume: 65
  start-page: 337
  year: 1996
  end-page: 365
  ident: CR28
  article-title: Telomere length regulation
  publication-title: Annu. Rev. Biochem
– volume: 65
  start-page: 801
  year: 2017
  end-page: 817
  ident: CR45
  article-title: NBS1 Phosphorylation status dictates repair choice of dysfunctional telomeres
  publication-title: Mol. Cell
– volume: 61
  start-page: 274
  year: 2016
  end-page: 286
  ident: CR85
  article-title: TRF2-Mediated control of telomere DNA topology as a mechanism for chromosome-end protection
  publication-title: Mol. Cell
– volume: 282
  start-page: 35416
  year: 2007
  end-page: 35423
  ident: CR18
  article-title: MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage
  publication-title: J. Biol. Chem.
– volume: 11
  start-page: 2337
  year: 2012
  end-page: 2347
  ident: CR79
  article-title: Timeless preserves telomere length by promoting efficient DNA replication through human telomeres
  publication-title: Cell Cycle
– volume: 27
  start-page: 1485
  year: 2017
  end-page: 1502
  ident: CR31
  article-title: Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex
  publication-title: Cell Res
– volume: 18
  start-page: 95
  year: 2006
  end-page: 101
  ident: CR2
  article-title: Cytoskeletal genes regulating brain size
  publication-title: Curr. Opin. Cell Biol.
– volume: 495
  start-page: 1
  year: 2012
  end-page: 9
  ident: CR10
  article-title: MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene
  publication-title: Gene
– volume: 72
  start-page: 568
  year: 2018
  end-page: 582
  ident: CR58
  article-title: CtIP-Mediated fork protection synergizes with BRCA1 to suppress genomic instability upon DNA replication stress
  publication-title: Mol. Cell
– volume: 96
  start-page: 597
  year: 2015
  end-page: 611
  ident: CR69
  article-title: Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma
  publication-title: Am. J. Hum. Genet.
– volume: 34
  start-page: 4368
  year: 2015
  end-page: 4378
  ident: CR26
  article-title: Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model
  publication-title: Oncogene
– volume: 26
  start-page: 4709
  year: 2007
  end-page: 4719
  ident: CR32
  article-title: Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
  publication-title: EMBO J.
– volume: 126
  start-page: 49
  year: 2006
  end-page: 62
  ident: CR108
  article-title: Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres
  publication-title: Cell
– volume: 218
  start-page: 1096
  year: 2019
  end-page: 1107
  ident: CR64
  article-title: Advances in understanding DNA processing and protection at stalled replication forks
  publication-title: J. Cell Biol.
– volume: 70
  start-page: 449
  year: 2018
  end-page: 461
  ident: CR86
  article-title: Genome-wide control of heterochromatin replication by the telomere capping protein TRF2
  publication-title: Mol. Cell
– volume: 434
  start-page: 913
  year: 2005
  end-page: 917
  ident: CR68
  article-title: Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
  publication-title: Nature
– volume: 5
  year: 2016
  ident: CR70
  article-title: Genomic analyses reveal FAM84B and the NOTCH pathway are associated with the progression of esophageal squamous cell carcinoma
  publication-title: Gigascience
– volume: 294
  start-page: 2361
  year: 2001
  end-page: 2364
  ident: CR55
  article-title: Visualization of DNA replication on individual Epstein-Barr virus episomes
  publication-title: Science
– volume: 15
  start-page: 2170
  year: 2016
  end-page: 2184
  ident: CR94
  article-title: Telomere replication stress induced by POT1 inactivation accelerates tumorigenesis
  publication-title: Cell Rep.
– volume: 170
  start-page: 457
  year: 2015
  end-page: 471
  ident: CR96
  article-title: Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder
  publication-title: Br. J. Haematol.
– volume: 421
  start-page: 643
  year: 2003
  end-page: 648
  ident: CR98
  article-title: Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
  publication-title: Nature
– volume: 11
  start-page: 365
  year: 2016
  end-page: 372
  ident: CR27
  article-title: Overexpression of MCPH1 inhibits uncontrolled cell growth by promoting cell apoptosis and arresting the cell cycle in S and G2/M phase in lung cancer cells
  publication-title: Oncol. Lett.
– volume: 7
  start-page: 712
  year: 2005
  end-page: 718
  ident: CR37
  article-title: DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
  publication-title: Nat. Cell Biol.
– volume: 319
  start-page: 1092
  year: 2008
  end-page: 1096
  ident: CR43
  article-title: A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins
  publication-title: Science
– volume: 71
  start-page: 136
  year: 2002
  end-page: 142
  ident: CR8
  article-title: Identification of microcephalin, a protein implicated in determining the size of the human brain
  publication-title: Am. J. Hum. Genet.
– volume: 131
  start-page: 4059
  year: 2004
  end-page: 4070
  ident: CR99
  article-title: Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells
  publication-title: Development
– volume: 11
  start-page: 865
  year: 2009
  end-page: 872
  ident: CR17
  article-title: BRIT1/MCPH1 links chromatin remodelling to DNA damage response
  publication-title: Nat. Cell Biol.
– volume: 28
  start-page: 2090
  year: 2014
  end-page: 2102
  ident: CR97
  article-title: Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1
  publication-title: Genes Dev.
– volume: 150
  start-page: 39
  year: 2012
  end-page: 52
  ident: CR83
  article-title: Telomeric 3’ overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST
  publication-title: Cell
– volume: 29
  start-page: 3708
  year: 2019
  end-page: 3725
  ident: CR40
  article-title: The replisome mediates A-NHEJ repair of telomeres lacking POT1-TPP1 independently of MRN function
  publication-title: Cell Rep.
– volume: 23
  start-page: 347
  year: 2018
  end-page: 350
  ident: CR14
  article-title: Novel compound heterozygous mutations in MCPH1 gene causes primary microcephaly in Saudi family
  publication-title: Neurosci. (Riyadh)
– volume: 60
  start-page: 2126
  year: 2004
  end-page: 2132
  ident: CR106
  article-title: Coot: model-building tools for molecular graphics
  publication-title: Acta Crystallogr. D. Biol. Crystallogr
– volume: 15
  start-page: 1597
  year: 2016
  end-page: 1610
  ident: CR76
  article-title: Multiomic analysis of the UV-Induced DNA damage response
  publication-title: Cell Rep.
– volume: 40
  start-page: 658
  year: 2007
  end-page: 674
  ident: CR104
  article-title: Phaser crystallographic software
  publication-title: J. Appl Crystallogr.
– volume: 12
  start-page: 645
  year: 2013
  end-page: 655
  ident: CR89
  article-title: DNA damage response in microcephaly development of MCPH1 mouse model
  publication-title: DNA Repair (Amst.)
– volume: 10
  start-page: 145
  year: 2006
  end-page: 157
  ident: CR16
  article-title: BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer
  publication-title: Cancer Cell
– volume: 31
  start-page: 107506
  year: 2020
  ident: CR90
  article-title: Cell metabolic alterations due to Mcph1 mutation in microcephaly
  publication-title: Cell Rep.
– volume: 145
  start-page: 529
  year: 2011
  end-page: 542
  ident: CR56
  article-title: Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11
  publication-title: Cell
– volume: 97
  start-page: 567
  year: 2006
  end-page: 581
  ident: CR100
  article-title: TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons
  publication-title: J. Neurochem
– volume: 57
  start-page: 622
  year: 2015
  end-page: 635
  ident: CR77
  article-title: TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding
  publication-title: Mol. Cell
– volume: 293
  start-page: 2462
  year: 2001
  end-page: 2465
  ident: CR51
  article-title: Strand-specific postreplicative processing of mammalian telomeres
  publication-title: Science
– volume: 105
  start-page: 10762
  year: 2008
  end-page: 10767
  ident: CR73
  article-title: A quantitative atlas of mitotic phosphorylation
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 434
  start-page: 917
  year: 2005
  end-page: 921
  ident: CR67
  article-title: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
  publication-title: Nature
– volume: 113
  start-page: 881
  year: 2003
  end-page: 889
  ident: CR9
  article-title: Multiple tumor suppressor pathways negatively regulate telomerase
  publication-title: Cell
– volume: 93
  start-page: 467
  year: 1998
  end-page: 476
  ident: CR4
  article-title: Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
  publication-title: Cell
– volume: 460
  start-page: 914
  year: 2009
  end-page: 918
  ident: CR33
  article-title: Multiple roles for MRE11 at uncapped telomeres
  publication-title: Nature
– volume: 52
  start-page: 223
  year: 2018
  end-page: 247
  ident: CR30
  article-title: Shelterin-mediated telomere protection
  publication-title: Annu. Rev. Genet
– volume: 7
  start-page: 2225
  year: 2008
  end-page: 2233
  ident: CR22
  article-title: Differential regulation of centrosome integrity by DNA damage response proteins
  publication-title: Cell Cycle
– volume: 535
  start-page: 382
  year: 2016
  end-page: 387
  ident: CR57
  article-title: Replication fork stability confers chemoresistance in BRCA-deficient cells
  publication-title: Nature
– volume: 72
  start-page: 127
  year: 2018
  end-page: 139
  ident: CR63
  article-title: The BRCT domains of the BRCA1 and BARD1 tumor suppressors differentially regulate homology-directed repair and stalled fork protection
  publication-title: Mol. Cell
– volume: 33
  start-page: 497
  year: 2003
  end-page: 501
  ident: CR3
  article-title: A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
  publication-title: Nat. Genet
– volume: 56
  start-page: 609
  year: 2013
  end-page: 613
  ident: CR12
  article-title: MCPH1 deletion in a newborn with severe microcephaly and premature chromosome condensation
  publication-title: Eur. J. Med. Genet.
– volume: 13
  start-page: 1325
  year: 2011
  end-page: 1334
  ident: CR88
  article-title: MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway
  publication-title: Nat. Cell Biol.
– volume: 149
  start-page: 795
  year: 2012
  end-page: 806
  ident: CR78
  article-title: RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity
  publication-title: Cell
– volume: 5
  start-page: e9242
  year: 2010
  ident: CR87
  article-title: Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function
  publication-title: PLoS ONE
– volume: 112
  start-page: 14864
  year: 2015
  end-page: 14869
  ident: CR61
  article-title: SMARCAL1 maintains telomere integrity during DNA replication
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 49
  start-page: 537
  year: 2017
  end-page: 549
  ident: CR5
  article-title: Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism
  publication-title: Nat. Genet
– volume: 58
  start-page: 1948
  year: 2002
  end-page: 1954
  ident: CR105
  article-title: PHENIX: building new software for automated crystallographic structure determination
  publication-title: Acta Crystallogr. D. Biol. Crystallogr.
– volume: 34
  start-page: 7836
  year: 2014
  end-page: 7844
  ident: CR101
  article-title: Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss
  publication-title: J. Neurosci.
– volume: 63
  start-page: 541
  year: 1998
  end-page: 546
  ident: CR7
  article-title: Primary autosomal recessive microcephaly (MCPH1) maps to chromosome 8p22-pter
  publication-title: Am. J. Hum. Genet.
– volume: 7
  year: 2016
  ident: CR39
  article-title: TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
  publication-title: Nat. Commun.
– volume: 19
  start-page: 177
  year: 2018
  end-page: 200
  ident: CR1
  article-title: The genetics of primary microcephaly
  publication-title: Annu. Rev. Genomics Hum. Genet.
– volume: 29
  start-page: 2230
  year: 2010
  end-page: 2241
  ident: CR82
  article-title: SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair
  publication-title: EMBO J.
– volume: 114
  start-page: 8354
  year: 2017
  end-page: 8359
  ident: CR21
  article-title: BRCT-domain protein BRIT1 influences class switch recombination
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 93
  start-page: 467
  year: 1998
  ident: 19674_CR4
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81174-5
– volume: 12
  start-page: 645
  year: 2013
  ident: 19674_CR89
  publication-title: DNA Repair (Amst.)
  doi: 10.1016/j.dnarep.2013.04.017
– volume: 27
  start-page: 1485
  year: 2017
  ident: 19674_CR31
  publication-title: Cell Res
  doi: 10.1038/cr.2017.144
– volume: 65
  start-page: 337
  year: 1996
  ident: 19674_CR28
  publication-title: Annu. Rev. Biochem
  doi: 10.1146/annurev.bi.65.070196.002005
– volume: 15
  start-page: 1597
  year: 2016
  ident: 19674_CR76
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.04.047
– volume: 495
  start-page: 1
  year: 2012
  ident: 19674_CR10
  publication-title: Gene
  doi: 10.1016/j.gene.2011.12.053
– volume: 97
  start-page: 567
  year: 2006
  ident: 19674_CR100
  publication-title: J. Neurochem
  doi: 10.1111/j.1471-4159.2006.03779.x
– volume: 132
  start-page: 487
  year: 2008
  ident: 19674_CR54
  publication-title: Cell
  doi: 10.1016/j.cell.2007.12.033
– volume: 6
  start-page: e1000826
  year: 2010
  ident: 19674_CR20
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1000826
– volume: 434
  start-page: 917
  year: 2005
  ident: 19674_CR67
  publication-title: Nature
  doi: 10.1038/nature03445
– volume: 282
  start-page: 35416
  year: 2007
  ident: 19674_CR18
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M705245200
– volume: 70
  start-page: 449
  year: 2018
  ident: 19674_CR86
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2018.03.036
– volume: 72
  start-page: 127
  year: 2018
  ident: 19674_CR63
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2018.08.016
– volume: 11
  start-page: 865
  year: 2009
  ident: 19674_CR17
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1895
– volume: 58
  start-page: 1948
  year: 2002
  ident: 19674_CR105
  publication-title: Acta Crystallogr. D. Biol. Crystallogr.
  doi: 10.1107/S0907444902016657
– volume: 29
  start-page: 3708
  year: 2019
  ident: 19674_CR40
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.11.012
– volume: 57
  start-page: 622
  year: 2015
  ident: 19674_CR77
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2014.12.024
– volume: 4
  start-page: 853
  year: 2013
  ident: 19674_CR72
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.07.033
– volume: 294
  start-page: 2361
  year: 2001
  ident: 19674_CR55
  publication-title: Science
  doi: 10.1126/science.1064603
– volume: 27
  start-page: 1323
  year: 2017
  ident: 19674_CR6
  publication-title: Genome Res
  doi: 10.1101/gr.219899.116
– volume: 102
  start-page: 15105
  year: 2005
  ident: 19674_CR15
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0507722102
– volume: 37
  start-page: 492
  year: 2010
  ident: 19674_CR65
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.01.021
– volume: 36
  start-page: 1939
  year: 2017
  ident: 19674_CR35
  publication-title: Oncogene
  doi: 10.1038/onc.2016.405
– volume: 23
  start-page: 347
  year: 2018
  ident: 19674_CR14
  publication-title: Neurosci. (Riyadh)
– volume: 4
  start-page: 861
  year: 2013
  ident: 19674_CR44
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.08.017
– volume: 60
  start-page: 77
  year: 2020
  ident: 19674_CR80
  publication-title: Curr. Opin. Genet Dev.
  doi: 10.1016/j.gde.2020.02.016
– volume: 7
  start-page: 712
  year: 2005
  ident: 19674_CR37
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1275
– volume: 68
  start-page: 414
  year: 2017
  ident: 19674_CR62
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.09.036
– volume: 9
  start-page: 4893
  year: 2010
  ident: 19674_CR23
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.24.14157
– volume: 75
  start-page: 261
  year: 2004
  ident: 19674_CR24
  publication-title: Am. J. Hum. Genet
  doi: 10.1086/422855
– volume: 29
  start-page: 2598
  year: 2010
  ident: 19674_CR36
  publication-title: EMBO J.
  doi: 10.1038/emboj.2010.142
– volume: 15
  start-page: 2170
  year: 2016
  ident: 19674_CR94
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.05.008
– volume: 11
  start-page: 2337
  year: 2012
  ident: 19674_CR79
  publication-title: Cell Cycle
  doi: 10.4161/cc.20810
– volume: 15
  start-page: 819
  year: 2012
  ident: 19674_CR93
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3097
– volume: 8
  start-page: 1583
  year: 2014
  ident: 19674_CR74
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.07.036
– volume: 34
  start-page: 4368
  year: 2015
  ident: 19674_CR26
  publication-title: Oncogene
  doi: 10.1038/onc.2014.367
– volume: 336
  start-page: 593
  year: 2012
  ident: 19674_CR41
  publication-title: Science
  doi: 10.1126/science.1218498
– volume: 52
  start-page: 223
  year: 2018
  ident: 19674_CR30
  publication-title: Annu. Rev. Genet
  doi: 10.1146/annurev-genet-032918-021921
– volume: 92
  start-page: 401
  year: 1998
  ident: 19674_CR48
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80932-0
– volume: 43
  start-page: 442
  year: 2011
  ident: 19674_CR71
  publication-title: Nat. Genet.
  doi: 10.1038/ng.810
– volume: 65
  start-page: 801
  year: 2017
  ident: 19674_CR45
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.01.016
– volume: 47
  start-page: 823
  year: 2010
  ident: 19674_CR11
  publication-title: J. Med. Genet
  doi: 10.1136/jmg.2009.076398
– volume: 460
  start-page: 914
  year: 2009
  ident: 19674_CR33
  publication-title: Nature
  doi: 10.1038/nature08196
– volume: 16
  start-page: 372
  year: 2009
  ident: 19674_CR42
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1575
– volume: 114
  start-page: 8354
  year: 2017
  ident: 19674_CR21
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1708211114
– volume: 7
  start-page: e40387
  year: 2012
  ident: 19674_CR46
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0040387
– volume: 33
  start-page: 497
  year: 2003
  ident: 19674_CR3
  publication-title: Nat. Genet
  doi: 10.1038/ng1129
– volume: 18
  start-page: 213
  year: 2011
  ident: 19674_CR38
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1974
– volume: 28
  start-page: 2477
  year: 2014
  ident: 19674_CR59
  publication-title: Genes Dev.
  doi: 10.1101/gad.251611.114
– volume: 126
  start-page: 49
  year: 2006
  ident: 19674_CR108
  publication-title: Cell
  doi: 10.1016/j.cell.2006.05.037
– volume: 23
  start-page: 2405
  year: 2009
  ident: 19674_CR60
  publication-title: Genes Dev.
  doi: 10.1101/gad.1839909
– volume: 145
  start-page: 529
  year: 2011
  ident: 19674_CR56
  publication-title: Cell
  doi: 10.1016/j.cell.2011.03.041
– volume: 31
  start-page: 9
  year: 2010
  ident: 19674_CR29
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgp268
– volume: 138
  start-page: 90
  year: 2009
  ident: 19674_CR52
  publication-title: Cell
  doi: 10.1016/j.cell.2009.06.021
– volume: 72
  start-page: 568
  year: 2018
  ident: 19674_CR58
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2018.09.014
– volume: 218
  start-page: 1096
  year: 2019
  ident: 19674_CR64
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201809012
– volume: 8
  start-page: e58156
  year: 2013
  ident: 19674_CR91
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0058156
– volume: 289
  start-page: 34284
  year: 2014
  ident: 19674_CR53
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.587113
– volume: 40
  start-page: 658
  year: 2007
  ident: 19674_CR104
  publication-title: J. Appl Crystallogr.
  doi: 10.1107/S0021889807021206
– volume: 5
  year: 2016
  ident: 19674_CR70
  publication-title: Gigascience
  doi: 10.1186/s13742-015-0107-0
– volume: 534
  start-page: 55
  year: 2016
  ident: 19674_CR75
  publication-title: Nature
  doi: 10.1038/nature18003
– volume: 13
  start-page: 1549
  year: 2003
  ident: 19674_CR49
  publication-title: Curr. Biol.
  doi: 10.1016/S0960-9822(03)00542-6
– volume: 60
  start-page: 2126
  year: 2004
  ident: 19674_CR106
  publication-title: Acta Crystallogr. D. Biol. Crystallogr
  doi: 10.1107/S0907444904019158
– volume: 96
  start-page: 597
  year: 2015
  ident: 19674_CR69
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2015.02.017
– volume: 113
  start-page: 881
  year: 2003
  ident: 19674_CR9
  publication-title: Cell
  doi: 10.1016/S0092-8674(03)00430-6
– volume: 124
  start-page: 491
  year: 2015
  ident: 19674_CR47
  publication-title: Chromosoma
  doi: 10.1007/s00412-015-0512-2
– volume: 170
  start-page: 457
  year: 2015
  ident: 19674_CR96
  publication-title: Br. J. Haematol.
  doi: 10.1111/bjh.13442
– volume: 194
  start-page: 841
  year: 2011
  ident: 19674_CR25
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201106141
– volume: 26
  start-page: 4709
  year: 2007
  ident: 19674_CR32
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601893
– volume: 56
  start-page: 609
  year: 2013
  ident: 19674_CR12
  publication-title: Eur. J. Med. Genet.
  doi: 10.1016/j.ejmg.2013.09.007
– volume: 29
  start-page: 2230
  year: 2010
  ident: 19674_CR82
  publication-title: EMBO J.
  doi: 10.1038/emboj.2010.58
– volume: 40
  start-page: 385
  year: 2003
  ident: 19674_CR95
  publication-title: J. Med. Genet
  doi: 10.1136/jmg.40.6.385
– volume: 11
  start-page: 365
  year: 2016
  ident: 19674_CR27
  publication-title: Oncol. Lett.
  doi: 10.3892/ol.2015.3857
– volume: 49
  start-page: 537
  year: 2017
  ident: 19674_CR5
  publication-title: Nat. Genet
  doi: 10.1038/ng.3790
– volume: 8
  start-page: 55
  year: 2017
  ident: 19674_CR66
  publication-title: Genes (Basel)
  doi: 10.3390/genes8020055
– volume: 319
  start-page: 1092
  year: 2008
  ident: 19674_CR43
  publication-title: Science
  doi: 10.1126/science.1151804
– volume: 63
  start-page: 541
  year: 1998
  ident: 19674_CR7
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/301966
– volume: 103
  start-page: 10017
  year: 2006
  ident: 19674_CR92
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0602436103
– volume: 131
  start-page: 4059
  year: 2004
  ident: 19674_CR99
  publication-title: Development
  doi: 10.1242/dev.01215
– volume: 434
  start-page: 913
  year: 2005
  ident: 19674_CR68
  publication-title: Nature
  doi: 10.1038/nature03443
– volume: 34
  start-page: 7836
  year: 2014
  ident: 19674_CR101
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4245-13.2014
– volume: 11
  start-page: 783
  year: 2014
  ident: 19674_CR107
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3047
– volume: 31
  start-page: 639
  year: 2017
  ident: 19674_CR102
  publication-title: Genes Dev.
  doi: 10.1101/gad.295402.116
– volume: 19
  start-page: 177
  year: 2018
  ident: 19674_CR1
  publication-title: Annu. Rev. Genomics Hum. Genet.
  doi: 10.1146/annurev-genom-083117-021441
– volume: 10
  start-page: 145
  year: 2006
  ident: 19674_CR16
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2006.07.002
– volume: 17
  start-page: 11
  year: 2010
  ident: 19674_CR50
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1710
– volume: 8
  start-page: 725
  year: 2006
  ident: 19674_CR19
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1431
– volume: 61
  start-page: 274
  year: 2016
  ident: 19674_CR85
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2015.12.009
– volume: 421
  start-page: 643
  year: 2003
  ident: 19674_CR98
  publication-title: Nature
  doi: 10.1038/nature01385
– volume: 571
  start-page: 149
  year: 2015
  ident: 19674_CR13
  publication-title: Gene
  doi: 10.1016/j.gene.2015.07.058
– volume: 150
  start-page: 39
  year: 2012
  ident: 19674_CR83
  publication-title: Cell
  doi: 10.1016/j.cell.2012.05.026
– volume: 276
  start-page: 307
  year: 1997
  ident: 19674_CR103
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(97)76066-X
– volume: 7
  start-page: 2225
  year: 2008
  ident: 19674_CR22
  publication-title: Cell Cycle
  doi: 10.4161/cc.7.14.6303
– volume: 149
  start-page: 795
  year: 2012
  ident: 19674_CR78
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.030
– volume: 5
  start-page: e9242
  year: 2010
  ident: 19674_CR87
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0009242
– volume: 31
  start-page: 107506
  year: 2020
  ident: 19674_CR90
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.03.070
– volume: 142
  start-page: 230
  year: 2010
  ident: 19674_CR84
  publication-title: Cell
  doi: 10.1016/j.cell.2010.05.032
– volume: 28
  start-page: 2090
  year: 2014
  ident: 19674_CR97
  publication-title: Genes Dev.
  doi: 10.1101/gad.248567.114
– volume: 7
  year: 2016
  ident: 19674_CR39
  publication-title: Nat. Commun.
– volume: 18
  start-page: 95
  year: 2006
  ident: 19674_CR2
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2005.11.004
– volume: 112
  start-page: 14864
  year: 2015
  ident: 19674_CR61
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1510750112
– volume: 71
  start-page: 136
  year: 2002
  ident: 19674_CR8
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/341283
– volume: 13
  start-page: 1325
  year: 2011
  ident: 19674_CR88
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2342
– volume: 297
  start-page: 565
  year: 2002
  ident: 19674_CR34
  publication-title: Science
  doi: 10.1126/science.297.5581.565
– volume: 535
  start-page: 382
  year: 2016
  ident: 19674_CR57
  publication-title: Nature
  doi: 10.1038/nature18325
– volume: 105
  start-page: 10762
  year: 2008
  ident: 19674_CR73
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0805139105
– volume: 293
  start-page: 2462
  year: 2001
  ident: 19674_CR51
  publication-title: Science
  doi: 10.1126/science.1062560
– volume: 39
  start-page: 606
  year: 2010
  ident: 19674_CR81
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.06.031
SSID ssj0000391844
Score 2.4251218
Snippet Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of...
Primary microcephaly is a clinical feature of several human telomere disorder syndromes. Here the authors reveal a role of Microcephalin 1 in promoting...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 5861
SubjectTerms 13/89
631/337
631/337/103/560
631/378
64/60
Aminopeptidases - genetics
Aminopeptidases - metabolism
Animals
Binding Sites
Calorimetry
Cell Cycle Proteins - chemistry
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Chromosomes
Crystal defects
Crystal structure
Cytoskeletal Proteins - chemistry
Cytoskeletal Proteins - genetics
Cytoskeletal Proteins - metabolism
Damage localization
Deoxyribonucleic acid
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - metabolism
Disorders
DNA
DNA Damage
DNA repair
Fibroblasts
HeLa Cells
Histones - genetics
Histones - metabolism
Homology
Humanities and Social Sciences
Humans
Localization
Mice
Microcephaly
Microcephaly - genetics
Microencephaly
multidisciplinary
Mutation
Protein Interaction Domains and Motifs
Protein structure
Proteins
Repair
Replication
Replication forks
Science
Science (multidisciplinary)
Serine Proteases - genetics
Serine Proteases - metabolism
Shelterin Complex
Telomerase
Telomerase reverse transcriptase
Telomere - genetics
Telomere - metabolism
Telomere-binding protein
Telomere-Binding Proteins - genetics
Telomere-Binding Proteins - metabolism
Telomeres
Telomeric Repeat Binding Protein 2 - chemistry
Telomeric Repeat Binding Protein 2 - genetics
Telomeric Repeat Binding Protein 2 - metabolism
TRF2 protein
Yeast
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELdgCIkXxDeBgYzEG4uaOE6cPCGGqAbSeJg6qW-W45zZpC0pafbQP4D_mzvHTVU-9lS1vjRO7s535zv_jrH3Lk3rWpg8TlyNAYpweVzKKokNUmOIi8FYQoeTT78XJ-fy2zJfhg23dSir3K6JfqFuOkt75DOBq2iu0Byrj6ufMXWNouxqaKFxl90j6DIq6VJLNe2xEPp5KWU4K5Nk5Wwt_cpAMROKnpJxsmePPGz_v3zNv0sm_8ibenM0f8QeBj-SfxoZ_5jdgfYJuz92ltw8Zb9OqdDOwuoC_eyWp7Pjs6-LNF6czQUnhIh-PM_AV74aD9Z8gKvuGnrgPUwZbW7ahr6by_6IhyYLO8Jmsyaj6AmHDv_Jw1bw692NN8_Y-fzL4vNJHDouxBY9tyGW-GGKwlaKcGvQN3EYztUYkYHFSMf7NqUVTZOXUDkLmSWwyVoJmwNUdQLZc3bQdi28ZLwpk0IYaFJXO2kE4LWENUObBQ5dqDxi6fa9axvgyKkrxpX2afGs1COvNPJKe17pJGIfpmvCU91KfUzsnCgJSNv_0PU_dNBLnToHKiusBQOyLkwFDRQmbdC0V3UOWcQOt8Kgg3av9U4WI_ZuGka9pGSLaaG7IRrqRCBkVkbsxSg700yyTFDVAI6oPanam-r-SHt54bG_VaEEenkRO9rK325a_38Vr25_itfsgfAqkcapOmQHQ38Db9DXGuq3XqF-A81oJ-c
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LbxMxELaqVkhcEOW50CIjcaNL196Hdw9VRRFRQQqHKpF6s2zvmFZKd8tmK5EfwP_u2PuIAoETpyjxOHHsmcz3xfY3hLyzjGnNVRpGViNB4TYN86SIQoXWSHGRjEXucvL0W3Y-T75eppc7ZCh31E_gciu1c_Wk5s3iw88fq1MM-JPuynh-vEx8uDsihP4kkhAp_B5mJuECddrDff_LHBdIaJL-7sz2rhv5ycv4b8Oefx6h_G0f1aenyWPyqMeV9GPnCPtkB6on5EFXaXL1lPyauoN3Bm6vEHdXlB2fXXyZsXB2MeHUKUY03f0GeutP58GStrCob6AB2sC4w01VVbrn6ro5on3RhbVhuVq6JOkN2xrfyctY0Jv1B6-ekfnk8-zTedhXYAgNIrk2TPBBZZkphNOxQaxikd5pZGhgkPl4rJMbXpZpDoU1EBsnPqkFNylAoSOIn5Pdqq7gJaFlHmVcQcmstonigH2d9oz788AipEoDwoZ5l6aXJ3dVMhbSb5PHuezWSuJaSb9WMgrI-7FP_63-aX3mlnO0dMLa_oW6-S77OJXMWhBxZgwoSHSmCighU6zEVF_oFOKAHAzOIAdnlRwzfCoQKoqAvB2bMU7d5ouqoL5zNq4yAU_iPCAvOt8ZRxLH3J0iwBax4VUbQ91sqa6vvBa4yARH1BeQo8H_1sP6-1S8-h9T8Zo85D5wWMjEAdltmzs4RITW6jc-7O4Bo6c5DQ
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELaqIiQuiDeBgozEjUaNHSdOjnTFqiCVQ7WVeotsZ0wrtUmVTQ_7A_jfzDiP1UJB4hRtPN5445mdb-zxN4x99EJYK00WJ95igCJ9FheqTGKD0hjiYjCW0OHk0-_5ybn6dpFd7DE5nYUJSfuB0jL8TU_ZYUdrFUyagh3UGa1iDNMfEHU7afUiX8zrKsR4Xig1no9J0uKerjs-KFD134cv_0yT_G2vNLig5RP2eMSO_PMw2qdsD5pn7OFQTXLznP08peQ6B7eXiK0bLo6Oz76uRLw6W0pOrBDdcIaB34YMPFjzHq7bG-iAdzDvYnPT1PTZXHWHfCyssBWsN2tyhEGwb_GbAlUFv9k-ePOCnS-_rBYn8VhlIXaI1vpY4cXkuSs1cdUgHvEYwlmMwsBhdBPwTOFkXWcFlN5B6ohg0mrpMoDSJpC-ZPtN28BrxusiyaWBWnjrlZGAfYlfhhYIPMKmLGJieu-VGynIqRLGdRW2wtOiGuaqwrmqwlxVScQ-zX3GX_VP6WOazlmSyLPDjbb7UY3KVAnvQae5c2BA2dyUUENuRI3uvLQZpBE7mJShGi16XUn04plGOKgj9mFuRlukDRbTQHtHMlR9QKq0iNirQXfmkaSppEwBbNE7WrUz1N2W5uoy8H3rXEtEdhE7nPRvO6y_v4o3_yf-lj2SwURELPQB2--7O3iHeKu374OB_QL-OSWv
  priority: 102
  providerName: Springer Nature
Title Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly
URI https://link.springer.com/article/10.1038/s41467-020-19674-0
https://www.ncbi.nlm.nih.gov/pubmed/33203878
https://www.proquest.com/docview/2471571257
https://www.proquest.com/docview/2461862438
https://pubmed.ncbi.nlm.nih.gov/PMC7672075
https://doaj.org/article/1ffe736cceae4b6a9ede6a1d1309b5e3
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db5swELe2TpP2Mu27bF3kSXtbUcAYDI9J1KyLlGrKUilvlm3OaqWWVIQ-5A_o_92zIUmzz5e9gMAHMfbZ97v4_DtCPts41pqpNIysRgeF2TTMeRGFCqXRxUVnLHKbk6dn2ek5nyzSxYNUXy4mrKUHbhuuH1sLIsmMAQVcZ6qAEjIVlzj3FjoFz_OJNu-BM-Xn4KRA14V3u2SiJO-vuJ8TnLeESid4GO1ZIk_Y_zuU-Wuw5E8rpt4QjV-Q5x2CpIO25i_JI6hekadtTsn1a3I3dSF2Bm4uEGFXNO4PZ9_mcTifjRl13BB1u5OB3vg4PFjRBq6W11ADrWG7lk1VVbprdVkf0y69wk6wXK-cOfSCzRLf5Akr6PXuh9dvyPn4ZD46DbtcC6FBzNaEHE8qy0whHGMNohKLjpxGXwwM-jge1eSGlWWaQ2ENJMbRTGrBTApQ6AiSt-SgWlZwSGiZRxlTUMZWW64Y4LOOZcb9TWARPKUBiTftLk1HRO7yYVxJvyCe5LLtK4l9JX1fySggX7bPdF_1V-mh686tpKPQ9jdQsWSnWPJfihWQo40yyG5cryRDW54KBIUiIJ-2xTgi3TKLqmB562RcDgLGkzwg71rd2dYkSZiLF8ASsadVe1XdL6kuLzzrt8gEQ3wXkOON_u2q9eemeP8_muIDecb8wInDWByRg6a-hY-IxRrdI4_FQuAxH3_tkSeDweTHBM_Dk7PvM7w7ykY9PzDxOOX5PbK1OQI
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtQw0CpFCC6IZwkUMBKcaLSJ83ByQIgCq13a7aHaSnszjjOhldpkyW6F9gP4Hb6RGeexWh699RQlnjh2ZjwPz3iGsdeF72eZ0JHrFRkaKKKI3CRMPVcjNJq4aIx5dDh5chSPTsIvs2i2xX51Z2EorLLjiZZR55WhPfKBQC4aSRTH8v38u0tVo8i72pXQaMjiAFY_0GRbvBt_Qvy-EWL4efpx5LZVBVyD2snSDfGi49ikknKzoPwt0GTJ0OoAg9q8ld-JEXkeJZAWBgJDCRUzKUwEkGYeBNjvDXYTBa9HK0rOZL-nQ9nWkzBsz-ZgX4NFaDkR2WhI6jJ0vQ35Z8sE_Eu3_TtE8w8_rRV_w3vsbqu38g8Nod1nW1A-YLeaSparh-znhAL7DMxPUa8vuT_YPx5PfXd6PBScMlLUzfkJPrfRf7DgSzivLqAGXkPvQee6zOlen9V7vC3qsAbMVwsSwhZwWWFPNk0Gv1h_ePWInVwLLh6z7bIq4QnjeeLFQkPuF1kRagH4LuW2oc2JAlW2yGF-99-VadOfUxWOc2Xd8EGiGlwpxJWyuFKew97277SzuhJ6n9DZQ1Libvugqr-plg8ovyhABrExoCHMYp1CDrH2c1Ql0iyCwGG7HTGolpss1Jr2Hfaqb0Y-QM4dXUJ1STBU-UCEQeKwnYZ2-pEEgaAoBWyRG1S1MdTNlvLs1OYal7EUqFU6bK-jv_Ww_v8rnl49i5fs9mg6OVSH46ODZ-yOsMvDd325y7aX9SU8Rz1vmb2wi4uzr9e9mn8Djbljog
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtQw0CpFIC6IN4ECRoITjTZ2Hk4OCFHKqktphaqttDeTOBNaqU2WZCu0H8BP8XXMOI_V8uitp2jjidfJvD3jGcZeFUJkmUxD1ysydFBkEbpxkHhuitDo4qIz5tHh5IPDaO84-DQLZxvsV38WhtIqe5loBXVeGdojH0mUoqFCdaxGRZcW8WV3_G7-3aUOUhRp7dtptCSyD8sf6L41bye7iOvXUo4_Tj_suV2HAdegpbJwA7ykUWQSRXVaUBcX6L5k6IGAQcve6vLYyDwPY0gKA76h4oqZkiYESDIPfJz3Gruu_FAQj6mZGvZ3qPJ6HATdOR2ca9QEViqRv4ZkrwLXW9OFtmXAv-zcv9M1_4jZWlU4vsNudzYsf98S3V22AeU9dqPtarm8z34eUJKfgfkJ2vglF6Odo8lUuNOjseRUnaJuz1Lwuc0EhIYv4Kw6hxp4DUM0nadlTr_T03qbdw0eVoD5siGFbAEXFc5kS2bw89UfLx-w4yvBxUO2WVYlPGY8j71IppCLIiuCVAI-S3VuaKOiQPMtdJjov7s2XSl06shxpm1I3o91iyuNuNIWV9pz2Jvhme6tLoXeIXQOkFTE296o6m-6kwlaFAUoPzIGUgiyKE0ghygVOZoVSRaC77Ctnhh0J1kaveIDh70chlEmUKAnLaG6IBjqgiADP3bYo5Z2hpX4vqSMBRxRa1S1ttT1kfL0xNYdV5GSaGE6bLunv9Wy_v8pnlz-Fi_YTeRj_XlyuP-U3ZKWO4Qr1BbbXNQX8AxNvkX23PIWZ1-vmpl_AzvXZ9g
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Microcephalin+1%2FBRIT1-TRF2+interaction+promotes+telomere+replication+and+repair%2C+linking+telomere+dysfunction+to+primary+microcephaly&rft.jtitle=Nature+communications&rft.au=Alessandro+Cicconi&rft.au=Rekha+Rai&rft.au=Xuexue+Xiong&rft.au=Cayla+Broton&rft.date=2020-11-17&rft.pub=Nature+Portfolio&rft.eissn=2041-1723&rft.volume=11&rft.issue=1&rft.spage=1&rft.epage=18&rft_id=info:doi/10.1038%2Fs41467-020-19674-0&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_1ffe736cceae4b6a9ede6a1d1309b5e3
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon