Targeting of radioactive platinum-bisphosphonate anticancer drugs to bone of high metabolic activity

Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance, and lack of tumor selectivity. Tumor-targeted drug delivery has demonstrated great potential to overcome these drawbacks. Herein, we aimed to d...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 10; no. 1; p. 5889
Main Authors Nadar, Robin A., Farbod, Kambiz, der Schilden, Karlijn Codee-van, Schlatt, Lukas, Crone, Barbara, Asokan, Nandini, Curci, Alessandra, Brand, Michael, Bornhaeuser, Martin, Iafisco, Michele, Margiotta, Nicola, Karst, Uwe, Heskamp, Sandra, Boerman, Otto C., van den Beucken, Jeroen J. J. P., Leeuwenburgh, Sander C. G.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 03.04.2020
Nature Publishing Group
Subjects
140/125
140/131
140/133
45/22
59
64/60
692/308
692/4017
692/4028/67/1344
692/4028/67/322/803
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Antineoplastic drugs
Antitumor agents
Bisphosphonates
Bone and Bones - drug effects
Bone and Bones - metabolism
Bone Neoplasms - drug therapy
Bone Neoplasms - metabolism
Calcium
Chemotherapy
Computed tomography
Diphosphonates - administration & dosage
Diphosphonates - therapeutic use
DNA adducts
Drug delivery
Drug Delivery Systems - methods
Drug resistance
Humanities and Social Sciences
Injections, Intravenous
Magnetic Resonance Spectroscopy
Male
Metabolism
Mice
Mice, Inbred C57BL
multidisciplinary
NMR
Nuclear magnetic resonance
Platinum
Platinum Compounds - administration & dosage
Platinum Compounds - therapeutic use
Radioisotopes
Science
Science (multidisciplinary)
Side effects
Single photon emission computed tomography
Tibia
Tibia - metabolism
Toxicity
Zebrafish
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-020-62039-2

Cover

Abstract Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance, and lack of tumor selectivity. Tumor-targeted drug delivery has demonstrated great potential to overcome these drawbacks. Herein, we aimed to design radioactive bisphosphonate-functionalized platinum ( 195m Pt-BP) complexes to confirm preferential accumulation of these Pt-based drugs in metabolically active bone. In vitro NMR studies revealed that release of Pt from Pt BP complexes increased with decreasing pH. Upon systemic administration to mice, Pt-BP exhibited a 4.5-fold higher affinity to bone compared to platinum complexes lacking the bone-seeking bisphosphonate moiety. These Pt-BP complexes formed less Pt-DNA adducts compared to bisphosphonate-free platinum complexes, indicating that in vivo release of Pt from Pt-BP complexes proceeded relatively slow. Subsequently, radioactive 195m Pt-BP complexes were synthesized using 195m Pt(NO 3 ) 2 (en) as precursor and injected intravenously into mice. Specific accumulation of 195m Pt-BP was observed at skeletal sites with high metabolic activity using micro-SPECT/CT imaging. Furthermore, laser ablation-ICP-MS imaging of proximal tibia sections confirmed that 195m Pt BP co-localized with calcium in the trabeculae of mice tibia.
AbstractList Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance, and lack of tumor selectivity. Tumor-targeted drug delivery has demonstrated great potential to overcome these drawbacks. Herein, we aimed to design radioactive bisphosphonate-functionalized platinum ( 195m Pt-BP) complexes to confirm preferential accumulation of these Pt-based drugs in metabolically active bone. In vitro NMR studies revealed that release of Pt from Pt BP complexes increased with decreasing pH. Upon systemic administration to mice, Pt-BP exhibited a 4.5-fold higher affinity to bone compared to platinum complexes lacking the bone-seeking bisphosphonate moiety. These Pt-BP complexes formed less Pt-DNA adducts compared to bisphosphonate-free platinum complexes, indicating that in vivo release of Pt from Pt-BP complexes proceeded relatively slow. Subsequently, radioactive 195m Pt-BP complexes were synthesized using 195m Pt(NO 3 ) 2 (en) as precursor and injected intravenously into mice. Specific accumulation of 195m Pt-BP was observed at skeletal sites with high metabolic activity using micro-SPECT/CT imaging. Furthermore, laser ablation-ICP-MS imaging of proximal tibia sections confirmed that 195m Pt BP co-localized with calcium in the trabeculae of mice tibia.
Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance, and lack of tumor selectivity. Tumor-targeted drug delivery has demonstrated great potential to overcome these drawbacks. Herein, we aimed to design radioactive bisphosphonate-functionalized platinum (195mPt-BP) complexes to confirm preferential accumulation of these Pt-based drugs in metabolically active bone. In vitro NMR studies revealed that release of Pt from Pt BP complexes increased with decreasing pH. Upon systemic administration to mice, Pt-BP exhibited a 4.5-fold higher affinity to bone compared to platinum complexes lacking the bone-seeking bisphosphonate moiety. These Pt-BP complexes formed less Pt-DNA adducts compared to bisphosphonate-free platinum complexes, indicating that in vivo release of Pt from Pt-BP complexes proceeded relatively slow. Subsequently, radioactive 195mPt-BP complexes were synthesized using 195mPt(NO3)2(en) as precursor and injected intravenously into mice. Specific accumulation of 195mPt-BP was observed at skeletal sites with high metabolic activity using micro-SPECT/CT imaging. Furthermore, laser ablation-ICP-MS imaging of proximal tibia sections confirmed that 195mPt BP co-localized with calcium in the trabeculae of mice tibia.
Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance, and lack of tumor selectivity. Tumor-targeted drug delivery has demonstrated great potential to overcome these drawbacks. Herein, we aimed to design radioactive bisphosphonate-functionalized platinum (195mPt-BP) complexes to confirm preferential accumulation of these Pt-based drugs in metabolically active bone. In vitro NMR studies revealed that release of Pt from Pt BP complexes increased with decreasing pH. Upon systemic administration to mice, Pt-BP exhibited a 4.5-fold higher affinity to bone compared to platinum complexes lacking the bone-seeking bisphosphonate moiety. These Pt-BP complexes formed less Pt-DNA adducts compared to bisphosphonate-free platinum complexes, indicating that in vivo release of Pt from Pt-BP complexes proceeded relatively slow. Subsequently, radioactive 195mPt-BP complexes were synthesized using 195mPt(NO3)2(en) as precursor and injected intravenously into mice. Specific accumulation of 195mPt-BP was observed at skeletal sites with high metabolic activity using micro-SPECT/CT imaging. Furthermore, laser ablation-ICP-MS imaging of proximal tibia sections confirmed that 195mPt BP co-localized with calcium in the trabeculae of mice tibia.Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance, and lack of tumor selectivity. Tumor-targeted drug delivery has demonstrated great potential to overcome these drawbacks. Herein, we aimed to design radioactive bisphosphonate-functionalized platinum (195mPt-BP) complexes to confirm preferential accumulation of these Pt-based drugs in metabolically active bone. In vitro NMR studies revealed that release of Pt from Pt BP complexes increased with decreasing pH. Upon systemic administration to mice, Pt-BP exhibited a 4.5-fold higher affinity to bone compared to platinum complexes lacking the bone-seeking bisphosphonate moiety. These Pt-BP complexes formed less Pt-DNA adducts compared to bisphosphonate-free platinum complexes, indicating that in vivo release of Pt from Pt-BP complexes proceeded relatively slow. Subsequently, radioactive 195mPt-BP complexes were synthesized using 195mPt(NO3)2(en) as precursor and injected intravenously into mice. Specific accumulation of 195mPt-BP was observed at skeletal sites with high metabolic activity using micro-SPECT/CT imaging. Furthermore, laser ablation-ICP-MS imaging of proximal tibia sections confirmed that 195mPt BP co-localized with calcium in the trabeculae of mice tibia.
Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance, and lack of tumor selectivity. Tumor-targeted drug delivery has demonstrated great potential to overcome these drawbacks. Herein, we aimed to design radioactive bisphosphonate-functionalized platinum ( Pt-BP) complexes to confirm preferential accumulation of these Pt-based drugs in metabolically active bone. In vitro NMR studies revealed that release of Pt from Pt BP complexes increased with decreasing pH. Upon systemic administration to mice, Pt-BP exhibited a 4.5-fold higher affinity to bone compared to platinum complexes lacking the bone-seeking bisphosphonate moiety. These Pt-BP complexes formed less Pt-DNA adducts compared to bisphosphonate-free platinum complexes, indicating that in vivo release of Pt from Pt-BP complexes proceeded relatively slow. Subsequently, radioactive Pt-BP complexes were synthesized using Pt(NO ) (en) as precursor and injected intravenously into mice. Specific accumulation of Pt-BP was observed at skeletal sites with high metabolic activity using micro-SPECT/CT imaging. Furthermore, laser ablation-ICP-MS imaging of proximal tibia sections confirmed that Pt BP co-localized with calcium in the trabeculae of mice tibia.
ArticleNumber 5889
Author Karst, Uwe
Heskamp, Sandra
Iafisco, Michele
Asokan, Nandini
Curci, Alessandra
der Schilden, Karlijn Codee-van
Leeuwenburgh, Sander C. G.
Brand, Michael
Nadar, Robin A.
Farbod, Kambiz
Bornhaeuser, Martin
Margiotta, Nicola
van den Beucken, Jeroen J. J. P.
Boerman, Otto C.
Crone, Barbara
Schlatt, Lukas
Author_xml – sequence: 1
  givenname: Robin A.
  surname: Nadar
  fullname: Nadar, Robin A.
  organization: Department of Dentistry - Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
– sequence: 2
  givenname: Kambiz
  surname: Farbod
  fullname: Farbod, Kambiz
  organization: Department of Dentistry - Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
– sequence: 3
  givenname: Karlijn Codee-van
  surname: der Schilden
  fullname: der Schilden, Karlijn Codee-van
  organization: Nuclear Research & Consultancy Group
– sequence: 4
  givenname: Lukas
  surname: Schlatt
  fullname: Schlatt, Lukas
  organization: Institute of Inorganic and Analytical Chemistry, University of Münster
– sequence: 5
  givenname: Barbara
  surname: Crone
  fullname: Crone, Barbara
  organization: Institute of Inorganic and Analytical Chemistry, University of Münster
– sequence: 6
  givenname: Nandini
  surname: Asokan
  fullname: Asokan, Nandini
  organization: Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Division of Hematology, Oncology and Stem Cell Transplantation, Department of Medicine I University Hospital Carl Gustav Carus, Technische Universität Dresden
– sequence: 7
  givenname: Alessandra
  surname: Curci
  fullname: Curci, Alessandra
  organization: Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via E. Orabona 4
– sequence: 8
  givenname: Michael
  surname: Brand
  fullname: Brand, Michael
  organization: Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
– sequence: 9
  givenname: Martin
  surname: Bornhaeuser
  fullname: Bornhaeuser, Martin
  organization: Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Division of Hematology, Oncology and Stem Cell Transplantation, Department of Medicine I University Hospital Carl Gustav Carus, Technische Universität Dresden, National Center for Tumor Diseases (NCT), Fetscherstrasse 74/PF 64, German Consortium for Translational Cancer Research (DKTK), DKFZ
– sequence: 10
  givenname: Michele
  surname: Iafisco
  fullname: Iafisco, Michele
  organization: Institute of Science and Technology for Ceramics (ISTEC), National Research Council (CNR)
– sequence: 11
  givenname: Nicola
  orcidid: 0000-0003-4034-875X
  surname: Margiotta
  fullname: Margiotta, Nicola
  organization: Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via E. Orabona 4
– sequence: 12
  givenname: Uwe
  orcidid: 0000-0002-1774-6787
  surname: Karst
  fullname: Karst, Uwe
  organization: Institute of Inorganic and Analytical Chemistry, University of Münster
– sequence: 13
  givenname: Sandra
  surname: Heskamp
  fullname: Heskamp, Sandra
  organization: Department of Radiology and Nuclear Medicine, Radboud University Medical Center
– sequence: 14
  givenname: Otto C.
  surname: Boerman
  fullname: Boerman, Otto C.
  organization: Department of Radiology and Nuclear Medicine, Radboud University Medical Center
– sequence: 15
  givenname: Jeroen J. J. P.
  orcidid: 0000-0002-0301-1966
  surname: van den Beucken
  fullname: van den Beucken, Jeroen J. J. P.
  organization: Department of Dentistry - Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
– sequence: 16
  givenname: Sander C. G.
  orcidid: 0000-0003-1471-6133
  surname: Leeuwenburgh
  fullname: Leeuwenburgh, Sander C. G.
  email: sander.leeuwenburgh@radboudumc.nl
  organization: Department of Dentistry - Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Institute of Science and Technology for Ceramics (ISTEC), National Research Council (CNR)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32246003$$D View this record in MEDLINE/PubMed
BookMark eNp9kU1rHSEYhaWkNGmaP9BFGeimm0n9nNFNoYR-BALdpGtx9L1zDTN6q04g_z7OvUmbZhFBFH3O4eh5i45CDIDQe4LPCWbyc-ZEKNliituOYqZa-gqdUMxFSxmlR0_2x-gs5xtch6CKE_UGHddT3mHMTpC7NmmE4sPYxE2TjPPR2OJvodlNph4vczv4vNvGdQZToDGheGuChdS4tIy5KbEZarZVv_XjtpmhmCFO3jZ7J1_u3qHXGzNlOHtYT9Hv79-uL362V79-XF58vWqt4Li03JJOGoYFKCf4Bng_cCKxsraznZTCqcFQCj12zDmumCXgCChKuO1dPwzsFH05-O6WYQZnIZRkJr1LfjbpTkfj9f83wW_1GG91T6igmFaDTw8GKf5ZIBc9-2xhmkyAuGRNmeyoVLITFf34DL2JSwr1eXuKCUEpqdSHp4n-RnksoALyANgUc06w0daX-vFxDegnTbBe69aHunWtW-_r1mtY-kz66P6iiB1EucJhhPQv9guqe26jvj0
CitedBy_id crossref_primary_10_1055_a_1759_1749
crossref_primary_10_1155_2022_3137142
crossref_primary_10_1016_j_bone_2020_115492
crossref_primary_10_1039_D1DT04079K
crossref_primary_10_3390_molecules28041959
crossref_primary_10_1002_cbdv_202400373
crossref_primary_10_1021_acs_jmedchem_1c02209
crossref_primary_10_2174_0929867328666210806110857
crossref_primary_10_1042_BSR20212160
crossref_primary_10_1016_j_cbpa_2021_03_003
crossref_primary_10_3390_ph17121591
crossref_primary_10_1155_2022_9261683
crossref_primary_10_3390_molecules26113417
crossref_primary_10_1016_j_molliq_2022_118619
crossref_primary_10_1039_D2CB00033D
crossref_primary_10_3390_molecules29153453
crossref_primary_10_1016_j_mtbio_2020_100088
crossref_primary_10_1039_D3DT00734K
Cites_doi 10.2967/jnumed.108.056606
10.1186/bcr2768
10.1016/j.bone.2010.05.038
10.1200/jco.2015.33.15_suppl.5012
10.1016/j.jbo.2018.100212
10.1007/s10555-007-9109-4
10.1016/j.jtemb.2019.04.011
10.1126/scitranslmed.aad4059
10.1021/acs.chemrestox.6b00380
10.2307/3578568
10.1016/j.heares.2011.12.001
10.2214/AJR.17.18264
10.1016/S0360-3016(00)01419-X
10.1016/j.jbo.2018.01.004
10.1016/j.clon.2007.03.010
10.1038/s41598-017-05246-8
10.1007/s10967-015-4053-1
10.1007/s12307-008-0010-7
10.1053/j.seminoncol.2003.11.017
10.1016/S0969-8043(99)00082-2
10.1016/j.remn.2015.08.006
10.1158/0008-5472.CAN-14-3477
10.1016/j.bbamcr.2014.12.033
10.1007/s00259-017-3643-2
10.1016/j.jinorgbio.2010.12.011
10.1016/j.bonr.2018.06.007
10.1186/s12885-017-3677-7
10.1007/s00109-015-1329-4
10.1159/000358258
10.1259/bjr.20170948
10.1016/S0169-5002(02)00169-1
10.1021/acs.chemrev.5b00597
10.1016/j.ejca.2016.10.021
10.1016/j.jbo.2016.02.004
10.1038/s41585-018-0020-2
10.1038/srep10881
10.1002/adfm.200600361
10.2967/jnumed.114.150391
10.1007/s10162-002-3022-x
10.1038/s41391-017-0020-y
10.1097/MD.0000000000003490
10.1021/acs.inorgchem.7b00931
10.1016/j.aquatox.2019.02.006
10.1016/j.cpet.2018.08.005
10.1186/bcr2781
10.1155/2013/213234
10.1016/j.phrs.2016.01.001
10.1089/ten.TEA.2016.0001
10.1039/b914379c
10.1039/b919721d
10.1016/j.clgc.2018.11.014
10.1089/cbr.2006.21.528
10.1039/b705239a
ContentType Journal Article
Copyright The Author(s) 2020
The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2020
– notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.1038/s41598-020-62039-2
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Science Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef
Publicly Available Content Database

MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: C6C
  name: SpringerOpen Free (Free internet resource, activated by CARLI)
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
ExternalDocumentID PMC7125202
32246003
10_1038_s41598_020_62039_2
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AASML
AAYXX
AFPKN
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
AARCD
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c540t-4c168a305e9d54fe47b41809cc6c6885d9ba22e70d3dd493c1ed1e9214c7d7bb3
IEDL.DBID 7X7
ISSN 2045-2322
IngestDate Thu Aug 21 18:34:44 EDT 2025
Fri Jul 11 14:51:21 EDT 2025
Wed Aug 13 03:27:14 EDT 2025
Thu Apr 03 07:10:00 EDT 2025
Tue Jul 01 03:24:11 EDT 2025
Thu Apr 24 22:59:39 EDT 2025
Fri Feb 21 02:38:40 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-4c168a305e9d54fe47b41809cc6c6885d9ba22e70d3dd493c1ed1e9214c7d7bb3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-0301-1966
0000-0002-1774-6787
0000-0003-4034-875X
0000-0003-1471-6133
OpenAccessLink https://www.proquest.com/docview/2386355221?pq-origsite=%requestingapplication%
PMID 32246003
PQID 2386355221
PQPubID 2041939
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7125202
proquest_miscellaneous_2386289865
proquest_journals_2386355221
pubmed_primary_32246003
crossref_citationtrail_10_1038_s41598_020_62039_2
crossref_primary_10_1038_s41598_020_62039_2
springer_journals_10_1038_s41598_020_62039_2
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-04-03
PublicationDateYYYYMMDD 2020-04-03
PublicationDate_xml – month: 04
  year: 2020
  text: 2020-04-03
  day: 03
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2020
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Aston (CR37) 2017; 17
von Moos, Costa, Ripamonti, Niepel, Santini (CR8) 2017; 71
Vokes, Choy, Gandara, Mattson (CR15) 2002; 38
CR38
Stornetta, Zimmermann, Cimino, Henderson, Sturla (CR36) 2017; 30
Parker, Heidenreich, Nilsson, Shore (CR12) 2018; 21
CR31
Brand, Granato, Nüsslein-Volhard, Nusslein-Volhard, Dahm (CR56) 2002; 7
Farbod (CR51) 2016; 22
Lee, Saylor, Smith (CR3) 2011; 48
Farrell, Karpeisky, Thamm, Zinnen (CR32) 2018; 9
Zhang (CR4) 2018; 11
Johnstone, Suntharalingam, Lippard (CR28) 2016; 116
Cui (CR47) 2017; 7
Body (CR5) 2019; 14
Buck, Winter, Redfern, Whitfield (CR48) 2012; 284
Bodnar, Dikiy, Medvedeva (CR23) 2015; 305
Heskamp (CR55) 2015; 75
Crone (CR35) 2019; 54
Curci (CR53) 2017; 56
Jadvar, Colletti (CR25) 2018; 91
Gnant, Hadji (CR6) 2010; 12
Jadvar (CR11) 2017; 209
Ren, Esposito, Kang (CR2) 2015; 93
Liu (CR44) 2015; 5
Wardman (CR17) 2007; 19
Areberg, Norrgren, Mattsson (CR19) 1999; 51
Chantrain, Feron, Marbaix, DeClerck (CR1) 2008; 1
Hung (CR49) 2019; 209
Bussard, Gay, Mastro (CR33) 2008; 27
Areberg, Wennerberg, Johnsson, Norrgren, Mattsson (CR20) 2001; 49
CR14
CR52
CR50
Raynor, Al-Zaghal, Zadeh, Seraj, Alavi (CR40) 2019; 14
Chen, Zhou, Fujita, Onozuka, Kubo (CR45) 2013; 2013
Nabell, Spencer (CR16) 2003; 30
Rao (CR42) 2016; 95
Kruger (CR26) 2015; 1853
Harris (CR57) 2003; 4
Price (CR10) 2016; 8
van der Have (CR54) 2009; 50
CR29
Caglar, Kupik, Karabulut, Hoilund-Carlsen (CR39) 2016; 35
Chen, Sosnoski, Mastro (CR34) 2010; 12
Howell (CR18) 1994; 140
Hillner (CR41) 2015; 56
CR22
Palazzo (CR30) 2007; 17
Lange, Spencer, Harder (CR21) 1972; 13
Morris (CR13) 2015; 33
Margiotta (CR43) 2011; 105
Fernandes (CR9) 2016; 5
Aalbersberg (CR24) 2017; 44
Amable (CR27) 2016; 106
Berish, Ali, Telmer, Ronald, Leong (CR46) 2018; 15
Cathomas (CR7) 2014; 92
62039_CR52
N Margiotta (62039_CR43) 2011; 105
KB Farrell (62039_CR32) 2018; 9
62039_CR14
R Cathomas (62039_CR7) 2014; 92
RC Lange (62039_CR21) 1972; 13
WY Raynor (62039_CR40) 2019; 14
JJ Cui (62039_CR47) 2017; 7
LM Buck (62039_CR48) 2012; 284
L Rao (62039_CR42) 2016; 95
EN Bodnar (62039_CR23) 2015; 305
RB Berish (62039_CR46) 2018; 15
H Zhang (62039_CR4) 2018; 11
62039_CR50
GY Hung (62039_CR49) 2019; 209
H Jadvar (62039_CR11) 2017; 209
62039_CR22
C Parker (62039_CR12) 2018; 21
62039_CR29
Y-C Chen (62039_CR34) 2010; 12
M Gnant (62039_CR6) 2010; 12
R Fernandes (62039_CR9) 2016; 5
J Areberg (62039_CR20) 2001; 49
EA Aalbersberg (62039_CR24) 2017; 44
MJ Morris (62039_CR13) 2015; 33
EE Vokes (62039_CR15) 2002; 38
BE Hillner (62039_CR41) 2015; 56
JJ Body (62039_CR5) 2019; 14
62039_CR31
B Crone (62039_CR35) 2019; 54
H Chen (62039_CR45) 2013; 2013
JA Harris (62039_CR57) 2003; 4
62039_CR38
KM Bussard (62039_CR33) 2008; 27
L Amable (62039_CR27) 2016; 106
B Palazzo (62039_CR30) 2007; 17
RJ Lee (62039_CR3) 2011; 48
G Ren (62039_CR2) 2015; 93
J Areberg (62039_CR19) 1999; 51
S Heskamp (62039_CR55) 2015; 75
M Brand (62039_CR56) 2002; 7
RW Howell (62039_CR18) 1994; 140
WJ Aston (62039_CR37) 2017; 17
TT Price (62039_CR10) 2016; 8
TC Johnstone (62039_CR28) 2016; 116
L Liu (62039_CR44) 2015; 5
R von Moos (62039_CR8) 2017; 71
L Nabell (62039_CR16) 2003; 30
CF Chantrain (62039_CR1) 2008; 1
H Jadvar (62039_CR25) 2018; 91
K Farbod (62039_CR51) 2016; 22
A Stornetta (62039_CR36) 2017; 30
K Kruger (62039_CR26) 2015; 1853
P Wardman (62039_CR17) 2007; 19
A Curci (62039_CR53) 2017; 56
M Caglar (62039_CR39) 2016; 35
F van der Have (62039_CR54) 2009; 50
References_xml – ident: CR22
– volume: 50
  start-page: 599
  year: 2009
  end-page: 605
  ident: CR54
  article-title: U-SPECT-II: An Ultra-High-Resolution Device for Molecular Small-Animal Imaging
  publication-title: J. Nucl. Med.
  doi: 10.2967/jnumed.108.056606
– volume: 7
  start-page: 39
  year: 2002
  ident: CR56
  article-title: Zebrafish: A practical approach
  publication-title: Keep. Rais. zebrafish
– volume: 12
  year: 2010
  ident: CR6
  article-title: Prevention of bone metastases and management of bone health in early breast cancer
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr2768
– volume: 48
  start-page: 88
  year: 2011
  end-page: 95
  ident: CR3
  article-title: Treatment and prevention of bone complications from prostate cancer
  publication-title: Bone
  doi: 10.1016/j.bone.2010.05.038
– volume: 33
  start-page: 5012
  year: 2015
  end-page: 5012
  ident: CR13
  article-title: Effects of radium-223 dichloride (Ra-223) with docetaxel (D) vs D on prostate-specific antigen (PSA) and bone alkaline phosphatase (bALP) in patients (pts) with castration-resistant prostate cancer (CRPC) and bone metastases (mets): A phase 1/2a clinical trial
  publication-title: J. Clin. Oncol.
  doi: 10.1200/jco.2015.33.15_suppl.5012
– volume: 14
  start-page: 100212
  year: 2019
  ident: CR5
  article-title: A real-world study assessing the use of bone-targeted agents and their impact on bone metastases in patients with prostate cancer treated in clinical practice in Europe
  publication-title: J. Bone Oncol.
  doi: 10.1016/j.jbo.2018.100212
– volume: 27
  start-page: 41
  year: 2008
  end-page: 55
  ident: CR33
  article-title: The bone microenvironment in metastasis; what is special about bone?
  publication-title: Cancer Metastasis Rev.
  doi: 10.1007/s10555-007-9109-4
– volume: 54
  start-page: 98
  year: 2019
  end-page: 102
  ident: CR35
  article-title: Quantitative imaging of platinum-based antitumor complexes in bone tissue samples using LA-ICP-MS
  publication-title: J. Trace Elem. Med. Biol.
  doi: 10.1016/j.jtemb.2019.04.011
– volume: 8
  start-page: 340ra373
  year: 2016
  ident: CR10
  article-title: Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aad4059
– ident: CR29
– volume: 30
  start-page: 388
  year: 2017
  end-page: 409
  ident: CR36
  article-title: DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/acs.chemrestox.6b00380
– volume: 140
  start-page: 55
  year: 1994
  end-page: 62
  ident: CR18
  article-title: Radiotoxicity of platinum-195m-labeled trans-platinum (II) in mammalian cells
  publication-title: Radiat. Res.
  doi: 10.2307/3578568
– volume: 284
  start-page: 67
  year: 2012
  end-page: 81
  ident: CR48
  article-title: Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish
  publication-title: Hear. Res.
  doi: 10.1016/j.heares.2011.12.001
– volume: 209
  start-page: 277
  year: 2017
  end-page: 288
  ident: CR11
  article-title: Targeted Radionuclide Therapy: An Evolution Toward Precision Cancer Treatment
  publication-title: AJR Am. J. Roentgenol.
  doi: 10.2214/AJR.17.18264
– volume: 49
  start-page: 827
  year: 2001
  end-page: 832
  ident: CR20
  article-title: Antitumor effect of radioactive cisplatin (191Pt) on nude mice
  publication-title: Int. J. Radiat. Oncol. Biol. Phys.
  doi: 10.1016/S0360-3016(00)01419-X
– volume: 11
  start-page: 38
  year: 2018
  end-page: 50
  ident: CR4
  article-title: Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data
  publication-title: J. Bone Oncol.
  doi: 10.1016/j.jbo.2018.01.004
– volume: 19
  start-page: 397
  year: 2007
  end-page: 417
  ident: CR17
  article-title: Chemical Radiosensitizers for Use in Radiotherapy
  publication-title: Clin. Oncol.
  doi: 10.1016/j.clon.2007.03.010
– volume: 7
  year: 2017
  ident: CR47
  article-title: Gene-gene and gene-environment interactions influence platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-05246-8
– ident: CR50
– volume: 305
  start-page: 133
  year: 2015
  end-page: 138
  ident: CR23
  article-title: Photonuclear production and antitumor effect of radioactive cisplatin (195mPt)
  publication-title: J. Radioanal. Nucl. Chem.
  doi: 10.1007/s10967-015-4053-1
– volume: 1
  start-page: 23
  year: 2008
  end-page: 35
  ident: CR1
  article-title: Bone Marrow Microenvironment and Tumor Progression
  publication-title: Cancer Microenviron.
  doi: 10.1007/s12307-008-0010-7
– volume: 30
  start-page: 89
  year: 2003
  end-page: 93
  ident: CR16
  article-title: Docetaxel with concurrent radiotherapy in head and neck cancer
  publication-title: Semin. Oncol.
  doi: 10.1053/j.seminoncol.2003.11.017
– volume: 51
  start-page: 581
  year: 1999
  end-page: 586
  ident: CR19
  article-title: Absorbed doses to patients from 191Pt-, 193mPt- and 195mPt-cisplatin
  publication-title: Appl. Radiat. Isotopes
  doi: 10.1016/S0969-8043(99)00082-2
– volume: 35
  start-page: 3
  year: 2016
  end-page: 11
  ident: CR39
  article-title: Detection of bone metastases in breast cancer patients in the PET/CT era: Do we still need the bone scan?
  publication-title: Rev. Esp. Med. Nucl. Imagen Mol.
  doi: 10.1016/j.remn.2015.08.006
– volume: 75
  start-page: 2928
  year: 2015
  end-page: 2936
  ident: CR55
  article-title: Noninvasive Imaging of Tumor PD-L1 Expression Using Radiolabeled Anti-PD-L1 Antibodies
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-3477
– volume: 1853
  start-page: 685
  year: 2015
  end-page: 698
  ident: CR26
  article-title: Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2014.12.033
– volume: 44
  start-page: 1347
  year: 2017
  end-page: 1354
  ident: CR24
  article-title: Preclinical imaging characteristics and quantification of Platinum-195m SPECT
  publication-title: Eur. J. Nucl. Med. Mol. Imaging
  doi: 10.1007/s00259-017-3643-2
– volume: 105
  start-page: 548
  year: 2011
  end-page: 557
  ident: CR43
  article-title: Platinum-bisphosphonate complexes have proven to be inactive chemotherapeutics targeted for malignant mesothelioma because of inappropriate hydrolysis
  publication-title: J. Inorg. Biochem.
  doi: 10.1016/j.jinorgbio.2010.12.011
– volume: 9
  start-page: 47
  year: 2018
  end-page: 60
  ident: CR32
  article-title: Bisphosphonate conjugation for bone specific drug targeting
  publication-title: Bone Rep.
  doi: 10.1016/j.bonr.2018.06.007
– volume: 17
  year: 2017
  ident: CR37
  article-title: A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice
  publication-title: BMC Cancer
  doi: 10.1186/s12885-017-3677-7
– ident: CR14
– volume: 93
  start-page: 1203
  year: 2015
  end-page: 1212
  ident: CR2
  article-title: Bone metastasis and the metastatic niche
  publication-title: J. Mol. Med.
  doi: 10.1007/s00109-015-1329-4
– volume: 92
  start-page: 377
  year: 2014
  end-page: 386
  ident: CR7
  article-title: Management of bone metastases in patients with castration-resistant prostate cancer
  publication-title: Urol. Int.
  doi: 10.1159/000358258
– volume: 91
  start-page: 20170948
  year: 2018
  ident: CR25
  article-title: (18)F-NaF/(223)RaCl2 theranostics in metastatic prostate cancer: treatment response assessment and prediction of outcome
  publication-title: Br. J. Radiol.
  doi: 10.1259/bjr.20170948
– volume: 13
  start-page: 328
  year: 1972
  end-page: 330
  ident: CR21
  article-title: Synthesis and distribution of a radiolabeled antitumor agent: cis-diamminedichloroplatinum
  publication-title: II. J. Nucl. Med.
– volume: 38
  start-page: 29
  year: 2002
  end-page: 35
  ident: CR15
  article-title: Adjuvant and neoadjuvant treatments for NSCLC
  publication-title: Lung Cancer
  doi: 10.1016/S0169-5002(02)00169-1
– volume: 116
  start-page: 3436
  year: 2016
  end-page: 3486
  ident: CR28
  article-title: The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
  publication-title: Chem. Rev.
  doi: 10.1021/acs.chemrev.5b00597
– volume: 71
  start-page: 80
  year: 2017
  end-page: 94
  ident: CR8
  article-title: Improving quality of life in patients with advanced cancer: Targeting metastatic bone pain
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2016.10.021
– volume: 5
  start-page: 57
  year: 2016
  end-page: 62
  ident: CR9
  article-title: Future directions for bone metastasis research - highlights from the 2015 bone and the Oncologist new updates conference (BONUS)
  publication-title: J. Bone Oncol.
  doi: 10.1016/j.jbo.2016.02.004
– volume: 15
  start-page: 403
  year: 2018
  end-page: 421
  ident: CR46
  article-title: Translational models of prostate cancer bone metastasis
  publication-title: Nat. Rev. Urol.
  doi: 10.1038/s41585-018-0020-2
– volume: 5
  year: 2015
  ident: CR44
  article-title: A new approach to reduce toxicities and to improve bioavailabilities of platinum-containing anti-cancer nanodrugs
  publication-title: Sci. Rep.
  doi: 10.1038/srep10881
– volume: 17
  start-page: 2180
  year: 2007
  end-page: 2188
  ident: CR30
  article-title: Biomimetic Hydroxyapatite–Drug Nanocrystals as Potential Bone Substitutes with Antitumor Drug Delivery Properties
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.200600361
– volume: 56
  start-page: 222
  year: 2015
  end-page: 228
  ident: CR41
  article-title: 18F-fluoride PET used for treatment monitoring of systemic cancer therapy: results from the National Oncologic PET Registry
  publication-title: J. Nucl. Med.
  doi: 10.2967/jnumed.114.150391
– volume: 4
  start-page: 219
  year: 2003
  end-page: 234
  ident: CR57
  article-title: Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio)
  publication-title: J. Assoc. Res. Otolaryngol.
  doi: 10.1007/s10162-002-3022-x
– volume: 21
  start-page: 37
  year: 2018
  end-page: 47
  ident: CR12
  article-title: Current approaches to incorporation of radium-223 in clinical practice
  publication-title: Prostate Cancer Prostatic Dis.
  doi: 10.1038/s41391-017-0020-y
– ident: CR38
– ident: CR52
– ident: CR31
– volume: 95
  start-page: e3490
  year: 2016
  ident: CR42
  article-title: 18F-Labeled NaF PET-CT in Detection of Bone Metastases in Patients With Preoperative Lung Cancer
  publication-title: Med.
  doi: 10.1097/MD.0000000000003490
– volume: 56
  start-page: 7482
  year: 2017
  end-page: 7493
  ident: CR53
  article-title: Novel Kiteplatin Pyrophosphate Derivatives with Improved Efficacy
  publication-title: Inorg. Chem.
  doi: 10.1021/acs.inorgchem.7b00931
– volume: 209
  start-page: 168
  year: 2019
  end-page: 177
  ident: CR49
  article-title: Cisplatin exposure impairs ionocytes and hair cells in the skin of zebrafish embryos
  publication-title: Aquat. Toxicol.
  doi: 10.1016/j.aquatox.2019.02.006
– volume: 14
  start-page: 135
  year: 2019
  end-page: 144
  ident: CR40
  article-title: Metastatic Seeding Attacks Bone Marrow, Not Bone: Rectifying Ongoing Misconceptions
  publication-title: PET. Clin.
  doi: 10.1016/j.cpet.2018.08.005
– volume: 12
  year: 2010
  ident: CR34
  article-title: Breast cancer metastasis to the bone: mechanisms of bone loss
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr2781
– volume: 2013
  start-page: 213234
  year: 2013
  ident: CR45
  article-title: Age-related changes in trabecular and cortical bone microstructure
  publication-title: Int. J. Endocrinol.
  doi: 10.1155/2013/213234
– volume: 106
  start-page: 27
  year: 2016
  end-page: 36
  ident: CR27
  article-title: Cisplatin resistance and opportunities for precision medicine
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2016.01.001
– volume: 22
  start-page: 788
  year: 2016
  end-page: 800
  ident: CR51
  article-title: Controlled Release of Chemotherapeutic Platinum-Bisphosphonate Complexes from Injectable Calcium Phosphate Cements
  publication-title: Tissue Eng. Part. A
  doi: 10.1089/ten.TEA.2016.0001
– volume: 14
  start-page: 135
  year: 2019
  ident: 62039_CR40
  publication-title: PET. Clin.
  doi: 10.1016/j.cpet.2018.08.005
– volume: 17
  start-page: 2180
  year: 2007
  ident: 62039_CR30
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.200600361
– ident: 62039_CR52
– volume: 22
  start-page: 788
  year: 2016
  ident: 62039_CR51
  publication-title: Tissue Eng. Part. A
  doi: 10.1089/ten.TEA.2016.0001
– volume: 48
  start-page: 88
  year: 2011
  ident: 62039_CR3
  publication-title: Bone
  doi: 10.1016/j.bone.2010.05.038
– volume: 35
  start-page: 3
  year: 2016
  ident: 62039_CR39
  publication-title: Rev. Esp. Med. Nucl. Imagen Mol.
  doi: 10.1016/j.remn.2015.08.006
– volume: 38
  start-page: 29
  year: 2002
  ident: 62039_CR15
  publication-title: Lung Cancer
  doi: 10.1016/S0169-5002(02)00169-1
– volume: 305
  start-page: 133
  year: 2015
  ident: 62039_CR23
  publication-title: J. Radioanal. Nucl. Chem.
  doi: 10.1007/s10967-015-4053-1
– volume: 50
  start-page: 599
  year: 2009
  ident: 62039_CR54
  publication-title: J. Nucl. Med.
  doi: 10.2967/jnumed.108.056606
– volume: 14
  start-page: 100212
  year: 2019
  ident: 62039_CR5
  publication-title: J. Bone Oncol.
  doi: 10.1016/j.jbo.2018.100212
– volume: 30
  start-page: 89
  year: 2003
  ident: 62039_CR16
  publication-title: Semin. Oncol.
  doi: 10.1053/j.seminoncol.2003.11.017
– volume: 19
  start-page: 397
  year: 2007
  ident: 62039_CR17
  publication-title: Clin. Oncol.
  doi: 10.1016/j.clon.2007.03.010
– volume: 5
  start-page: 57
  year: 2016
  ident: 62039_CR9
  publication-title: J. Bone Oncol.
  doi: 10.1016/j.jbo.2016.02.004
– volume: 75
  start-page: 2928
  year: 2015
  ident: 62039_CR55
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-3477
– volume: 44
  start-page: 1347
  year: 2017
  ident: 62039_CR24
  publication-title: Eur. J. Nucl. Med. Mol. Imaging
  doi: 10.1007/s00259-017-3643-2
– volume: 71
  start-page: 80
  year: 2017
  ident: 62039_CR8
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2016.10.021
– ident: 62039_CR31
  doi: 10.1039/b914379c
– ident: 62039_CR50
  doi: 10.1039/b919721d
– ident: 62039_CR14
  doi: 10.1016/j.clgc.2018.11.014
– volume: 7
  year: 2017
  ident: 62039_CR47
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-05246-8
– volume: 21
  start-page: 37
  year: 2018
  ident: 62039_CR12
  publication-title: Prostate Cancer Prostatic Dis.
  doi: 10.1038/s41391-017-0020-y
– volume: 4
  start-page: 219
  year: 2003
  ident: 62039_CR57
  publication-title: J. Assoc. Res. Otolaryngol.
  doi: 10.1007/s10162-002-3022-x
– volume: 2013
  start-page: 213234
  year: 2013
  ident: 62039_CR45
  publication-title: Int. J. Endocrinol.
  doi: 10.1155/2013/213234
– volume: 12
  year: 2010
  ident: 62039_CR6
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr2768
– volume: 8
  start-page: 340ra373
  year: 2016
  ident: 62039_CR10
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aad4059
– volume: 91
  start-page: 20170948
  year: 2018
  ident: 62039_CR25
  publication-title: Br. J. Radiol.
  doi: 10.1259/bjr.20170948
– volume: 33
  start-page: 5012
  year: 2015
  ident: 62039_CR13
  publication-title: J. Clin. Oncol.
  doi: 10.1200/jco.2015.33.15_suppl.5012
– volume: 209
  start-page: 168
  year: 2019
  ident: 62039_CR49
  publication-title: Aquat. Toxicol.
  doi: 10.1016/j.aquatox.2019.02.006
– volume: 105
  start-page: 548
  year: 2011
  ident: 62039_CR43
  publication-title: J. Inorg. Biochem.
  doi: 10.1016/j.jinorgbio.2010.12.011
– ident: 62039_CR22
  doi: 10.1089/cbr.2006.21.528
– volume: 15
  start-page: 403
  year: 2018
  ident: 62039_CR46
  publication-title: Nat. Rev. Urol.
  doi: 10.1038/s41585-018-0020-2
– volume: 95
  start-page: e3490
  year: 2016
  ident: 62039_CR42
  publication-title: Med.
  doi: 10.1097/MD.0000000000003490
– volume: 54
  start-page: 98
  year: 2019
  ident: 62039_CR35
  publication-title: J. Trace Elem. Med. Biol.
  doi: 10.1016/j.jtemb.2019.04.011
– volume: 17
  year: 2017
  ident: 62039_CR37
  publication-title: BMC Cancer
  doi: 10.1186/s12885-017-3677-7
– volume: 9
  start-page: 47
  year: 2018
  ident: 62039_CR32
  publication-title: Bone Rep.
  doi: 10.1016/j.bonr.2018.06.007
– volume: 1853
  start-page: 685
  year: 2015
  ident: 62039_CR26
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2014.12.033
– volume: 284
  start-page: 67
  year: 2012
  ident: 62039_CR48
  publication-title: Hear. Res.
  doi: 10.1016/j.heares.2011.12.001
– volume: 27
  start-page: 41
  year: 2008
  ident: 62039_CR33
  publication-title: Cancer Metastasis Rev.
  doi: 10.1007/s10555-007-9109-4
– ident: 62039_CR29
  doi: 10.1039/b705239a
– volume: 12
  year: 2010
  ident: 62039_CR34
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr2781
– volume: 49
  start-page: 827
  year: 2001
  ident: 62039_CR20
  publication-title: Int. J. Radiat. Oncol. Biol. Phys.
  doi: 10.1016/S0360-3016(00)01419-X
– volume: 13
  start-page: 328
  year: 1972
  ident: 62039_CR21
  publication-title: II. J. Nucl. Med.
– volume: 56
  start-page: 222
  year: 2015
  ident: 62039_CR41
  publication-title: J. Nucl. Med.
  doi: 10.2967/jnumed.114.150391
– volume: 30
  start-page: 388
  year: 2017
  ident: 62039_CR36
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/acs.chemrestox.6b00380
– volume: 1
  start-page: 23
  year: 2008
  ident: 62039_CR1
  publication-title: Cancer Microenviron.
  doi: 10.1007/s12307-008-0010-7
– volume: 51
  start-page: 581
  year: 1999
  ident: 62039_CR19
  publication-title: Appl. Radiat. Isotopes
  doi: 10.1016/S0969-8043(99)00082-2
– volume: 7
  start-page: 39
  year: 2002
  ident: 62039_CR56
  publication-title: Keep. Rais. zebrafish
– volume: 92
  start-page: 377
  year: 2014
  ident: 62039_CR7
  publication-title: Urol. Int.
  doi: 10.1159/000358258
– volume: 140
  start-page: 55
  year: 1994
  ident: 62039_CR18
  publication-title: Radiat. Res.
  doi: 10.2307/3578568
– ident: 62039_CR38
– volume: 56
  start-page: 7482
  year: 2017
  ident: 62039_CR53
  publication-title: Inorg. Chem.
  doi: 10.1021/acs.inorgchem.7b00931
– volume: 11
  start-page: 38
  year: 2018
  ident: 62039_CR4
  publication-title: J. Bone Oncol.
  doi: 10.1016/j.jbo.2018.01.004
– volume: 116
  start-page: 3436
  year: 2016
  ident: 62039_CR28
  publication-title: Chem. Rev.
  doi: 10.1021/acs.chemrev.5b00597
– volume: 5
  year: 2015
  ident: 62039_CR44
  publication-title: Sci. Rep.
  doi: 10.1038/srep10881
– volume: 93
  start-page: 1203
  year: 2015
  ident: 62039_CR2
  publication-title: J. Mol. Med.
  doi: 10.1007/s00109-015-1329-4
– volume: 106
  start-page: 27
  year: 2016
  ident: 62039_CR27
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2016.01.001
– volume: 209
  start-page: 277
  year: 2017
  ident: 62039_CR11
  publication-title: AJR Am. J. Roentgenol.
  doi: 10.2214/AJR.17.18264
SSID ssj0000529419
Score 2.39402
Snippet Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance,...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 5889
SubjectTerms 140/125
140/131
140/133
45/22
59
64/60
692/308
692/4017
692/4028/67/1344
692/4028/67/322/803
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Antineoplastic drugs
Antitumor agents
Bisphosphonates
Bone and Bones - drug effects
Bone and Bones - metabolism
Bone Neoplasms - drug therapy
Bone Neoplasms - metabolism
Calcium
Chemotherapy
Computed tomography
Diphosphonates - administration & dosage
Diphosphonates - therapeutic use
DNA adducts
Drug delivery
Drug Delivery Systems - methods
Drug resistance
Humanities and Social Sciences
Injections, Intravenous
Magnetic Resonance Spectroscopy
Male
Metabolism
Mice
Mice, Inbred C57BL
multidisciplinary
NMR
Nuclear magnetic resonance
Platinum
Platinum Compounds - administration & dosage
Platinum Compounds - therapeutic use
Radioisotopes
Science
Science (multidisciplinary)
Side effects
Single photon emission computed tomography
Tibia
Tibia - metabolism
Toxicity
Zebrafish
SummonAdditionalLinks – databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS-QwEA-iCL6In-d6KhHuTatNmjbpw3GIKCLokwu-lXz1XFjbtdsF_e9vph97rF8PfUomaTIf-Q2TzBDyKw9NrDVTgec8D0Si8iA1xgRxFDNlXCRkgq-R7-6Tm6G4fYwfl0hf7qjbwOmnrh3WkxpW47PXl7c_oPC_2yfj6nwKhxA-FENHiGNkE0zyCpxMEhX1roP7ba5vngqWdm9nPiddPJ8-gM6PdyffBVCbc-l6g6x3gJJetBKwSZZ8sUVW2xKTb9vEPTRXvYGUljmttBuVujFxdIK34IrZM_jG08lTiV8BwJPCVqNptL6irpr9ndK6pKYsPNJjcmP67GuQnPHI0mYkgPE7ZHh99XB5E3SVFQILCK0OhGWJ0qDqPnWxyL2QRmAiL2sTmygVu9Rozr0MXeScSCPLvGM-5UxY6aQx0S5ZLmDmPUK1tIkwjFsWGoBmGhxGzjWM52IfcscHhPX7mdku7ThWvxhnTfg7UlnLgwx4kDU8yIDmZE4zaZNufNv7oGdT1stPBkgEoRTnbECO582gOhgP0YUvZ20f8DdVEg_Ij5ar8-kiTLQHFm9A5AK_5x0wLfdiSzF6atJzS8CMPITfOu0l4_9vfb2K_e9X8ZOscZRSvDMUHZDlupr5Q4BDtTlqZPwfhg4GtA
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LT9wwELYQVSUuiNICWyhypd7aiPgRxzmiVdEKiZ5A4hb5FVgJktVu9sC_74zzQFseUg85xeNHZjz-nBl_JuRHldrMGKaTwHmVSKWrpLDWJpnImLZeyFzhaeSrP2p2Iy9vs9stwoezMDFpP1JaRjc9ZIedrWChwcNguNnhGL0Et_sBqdvRqqdqOv5XwciVZEV_PiYV-hXRzTXoBbB8mR_5T5A0rj0Xe2S3B430vOvmJ7IV6n3ysbtG8ukz8dcxnRtEaVPRpfHzxkQ3RheY6VavH2H_u1rcN_jAsAOFz4nuz4Ul9cv13Yq2DbVNHVAeCYzpY2jBOh7mjsaaAKp_ITcXv6-ns6S_PSFxgMLaRDqmtIHpHAqfySrI3Eok63JOOaV15gtrOA956oX3shCOBc9CwZl0uc-tFQdku4aWjwg1uVPSMu5YagF-GdgUcm6gPp-FlHs-IWz4nqXrqcXxhouHMoa4hS47HZSggzLqoASZn6PMoiPWeLf0yaCmsp9kqxLQBsIlztmEfB9fw_TAmIepQ7PuysCeUqtsQg47rY7NCSTTA682IfmGvscCSL29-aae30cK7hxwIU-hW78Gy3ju1tuj-Pp_xY_JDkerxTwhcUK22-U6fAMI1NrTaPN_ATOnAVY
  priority: 102
  providerName: Springer Nature
Title Targeting of radioactive platinum-bisphosphonate anticancer drugs to bone of high metabolic activity
URI https://link.springer.com/article/10.1038/s41598-020-62039-2
https://www.ncbi.nlm.nih.gov/pubmed/32246003
https://www.proquest.com/docview/2386355221
https://www.proquest.com/docview/2386289865
https://pubmed.ncbi.nlm.nih.gov/PMC7125202
Volume 10
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR1da9swUGwtg72MdV9N1wYN9raZWrJsyU8jDS0l0DK2FvJm9OU10NpZ7Dz03-9OdlzSsj7YButbd7o76U53hHwtY5NqzVTkOS8jkakyyo0xUZqkTBmXCJnhbeSLy-z8Wszm6bw_cGt6s8oNTQyE2tUWz8iPgbUgb-Sc_Vj-jTBqFGpX-xAaL8kuui5Dky45l8MZC2qxBMv7uzJxoo4b4Fd4pwz3TByVoHybHz0RMp_aSj5SmAY-dPaWvOkFSDrpIL5HXvjqHXnVhZS8f0_cVTDthqK0LulKu0WtA0mjS7R6q9Z3sBduljc1PhUImhSmFkmh9SvqVus_DW1raurKY3l0ZkzvfAuYcruwNNQEYvsHcn12ejU9j_pICpEFiayNhGWZ0rC0fe5SUXohjUDHXdZmNlMqdbnRnHsZu8Q5kSeWecd8zpmw0kljko9kp4KW9wnV0mbCMG5ZbEAU07BB5FxDfS71MXd8RNhmPgvbuxnHaBe3RVB3J6roYFAADIoAgwLKfBvKLDsnG8_mPtyAqegXXFM8oMeIfBmSYamg_kNXvl53eWB_qbJ0RD51UB2aS9CxHlC4EZFb8B4yoBvu7ZRqcRPccUuQEXkM3fq-wYyHbv1_FAfPj-Izec0RS9FGKDkkO-1q7Y9A_GnNOOD4mOxOJrPfM_ienF7-_AV_p9l0HI4U4H0h1D9hgQlY
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3ZbtQwcFS2QvCCuFkoYCR4gqjxkesBIY5WW9quENpKfQvxEbpSmyybrFB_im9kJle1VPStD3myx4494zk84xmA17mvgyzjseeEyD0VxrmXaK29QAY81laqKKTXyIfTcHKkvh4Hxxvwp38LQ2GVPU9sGLUtDd2Rb6NoIdkoBP-w-OVR1SjyrvYlNFqy2Hfnv9Fkq97vfUH8vhFid2f2eeJ1VQU8g9pJ7SnDwzhDMneJDVTuVKQVJbEyJjRhHAc20ZkQLvKttFYl0nBnuUsEVyaykdYSx70Bm0qiKTOCzU8702_fh1sd8pspnnSvc3wZb1coIekVG1lpgtyuYl0CXlJrL0dn_uOibSTf7l2406ms7GNLY_dgwxX34WZbxPL8AdhZE0yOoKzM2TKz8zJrmChbUJxdsTpD67tanJT0FajaMkQmMV_jlswuVz8rVpdMl4UjeEqfzM5cjbR5OjesGQkNhYdwdC27_AhGBc78BFgWmVBpLgz3NSp_GZqkQmQ4ng2cL6wYA-_3MzVdYnOqr3GaNg52GactDlLEQdrgIEWYtwPMok3rcWXvrR5NaXfEq_SCIMfwamjGw0kel6xw5artgxZtHAZjeNxidZhOUio_5KljiNbwPXSgxN_rLcX8pEkAHqFWKnz8rXc9ZVz81v9X8fTqVbyEW5PZ4UF6sDfdfwa3BVEsRSjJLRjVy5V7jspXrV90FM_gx3Ufsr8cV0H1
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtQwcFSKQFwqnmVLASPBCaKNHSdODgghyqqlUHFopb0Fv0JXapNlNyvUX-PrmMmrWip66yEnv2LP2zOeAXhdhCbWmqeBF6IIZJIWQWaMCeIo5qlxkVQJvUb-dpTsn8gv03i6AX_6tzAUVtnzxIZRu8rSHfkYRQvJRiH4uOjCIr7vTT7MfwVUQYo8rX05jRZFDv3FbzTflu8P9hDWb4SYfD7-tB90FQYCi5pKHUjLk1QjyvvMxbLwUhlJCa2sTWySprHLjBbCq9BFzsksstw77jPBpVVOGRPhvLfgtsKNEY2pqRrud8iDJnnWvdMJo3S8RFlJ79nIXhPkgBXrsvCKgns1TvMfZ20jAyf3YatTXtnHFtsewIYvH8KdtpzlxSNwx01YOQ5lVcEW2s0q3bBTNqeIu3J1jnb4cn5a0VeikssQrMSGrV8wt1j9XLK6YqYqPY2nRMrs3NeIpWczy5qZ0GR4DCc3csZPYLPElZ8C08om0nBheWhQDdRonAqhcT4X-1A4MQLen2duuxTnVGnjLG9c7VGatzDIEQZ5A4Mcx7wdxszbBB_X9t7twZR3xL7ML1FzBK-GZiRT8r3o0lertg_atmkSj2C7heqwXERJ_ZC7jkCtwXvoQCnA11vK2WmTClyhfipC_K13PWZc_tb_d7Fz_S5ewl0krfzrwdHhM7gnCGEpVCnahc16sfLPUQurzYsG3Rn8uGn6-guLFETF
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Targeting+of+radioactive+platinum-bisphosphonate+anticancer+drugs+to+bone+of+high+metabolic+activity&rft.jtitle=Scientific+reports&rft.au=Nadar%2C+Robin+A&rft.au=Farbod+Kambiz&rft.au=der+Schilden+Karlijn+Codee-van&rft.au=Schlatt+Lukas&rft.date=2020-04-03&rft.pub=Nature+Publishing+Group&rft.eissn=2045-2322&rft.volume=10&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-020-62039-2&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon