Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance

• Published in: Nature communications Vol. 12; no. 1; pp. 3364 - 18
• Main Authors: Garcia, Laura Ramos, Tenev, Tencho, Newman, Richard, Haich, Rachel O., Liccardi, Gianmaria, John, Sidonie Wicky, Annibaldi, Alessandro, Yu, Lu, Pardo, Mercedes, Young, Samuel N., Fitzgibbon, Cheree, Fernando, Winnie, Guppy, Naomi, Kim, Hyojin, Liang, Lung-Yu, Lucet, Isabelle S., Kueh, Andrew, Roxanis, Ioannis, Gazinska, Patrycja, Sims, Martin, Smyth, Tomoko, Ward, George, Bertin, John, Beal, Allison M., Geddes, Brad, Choudhary, Jyoti S., Murphy, James M., Aurelia Ball, K., Upton, Jason W., Meier, Pascal
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.06.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 14/34; 38/70; 631/337/458/582; 631/80/458/582; 631/80/82/2344; 64/60; 82/58; 96/1; Animals; Apoptosis; Assembly; Cell death; Cell Line; Cells, Cultured; Clearances; Cytotoxicity; HEK293 Cells; Herpesviridae Infections - genetics; Herpesviridae Infections - metabolism; Herpesviridae Infections - virology; HT29 Cells; Humanities and Social Sciences; Humans; Inflammation; Lysine; Lysine - genetics; Lysine - metabolism; Membranes; Mice; Mice, Inbred C57BL; Mice, Knockout; Mortality; multidisciplinary; Muromegalovirus - physiology; Mutation; Necroptosis; Necroptosis - genetics; Necrosis; NIH 3T3 Cells; Oligomerization; Pathogenesis; Pathogens; Phosphorylation; Protein Kinases - genetics; Protein Kinases - metabolism; Rupture; Science; Science (multidisciplinary); Signalling systems; Skin - metabolism; Skin - pathology; Toxicity; Translocation; Ubiquitin; Ubiquitination

Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis is triggered by RIPK3-mediated phosphorylation of MLKL, which is thought to initiate MLKL oligomerisation, membrane translocation and membran...