Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

• Published in: Scientific reports Vol. 12; no. 1; pp. 20608 - 11
• Main Authors: Bertrams, Wilhelm, Hönzke, Katja, Obermayer, Benedikt, Tönnies, Mario, Bauer, Torsten T., Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Stiewe, Thorsten, Nist, Andrea, Eggeling, Stephan, Suttorp, Norbert, Wolff, Thorsten, Hippenstiel, Stefan, Schmeck, Bernd, Hocke, Andreas C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.11.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250; 631/337; A549 Cells; Adenocarcinoma; Alveolar Epithelial Cells; Alveoli; Gene expression; Humanities and Social Sciences; Humans; Influenza; Influenza A; Influenza A virus; Influenza A Virus, H3N2 Subtype; Influenza, Human - genetics; Interferon; Lungs; Macrophages; multidisciplinary; Pandemics; Replication; Science; Science (multidisciplinary); Tissues; Transcriptome; Transcriptomics

Influenza A virus (IAV) causes pandemics and annual epidemics of severe respiratory infections. A better understanding of the molecular regulation in tissue and cells upon IAV infection is needed to thoroughly understand pathogenesis. We analyzed IAV replication and gene expression induced by IAV st...