A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types

• Published in: Nature (London) Vol. 598; no. 7879; pp. 214 - 219
• Main Authors: Kozareva, Velina, Martin, Caroline, Osorno, Tomas, Rudolph, Stephanie, Guo, Chong, Vanderburg, Charles, Nadaf, Naeem, Regev, Aviv, Regehr, Wade G., Macosko, Evan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.10.2021; Nature Publishing Group
• Subjects: 13; 38/32; 45; 45/91; 631/378/87; 631/61/212; 64/60; 9/74; Adult; Animals; Atlases as Topic; Autonomic nervous system; Brain; Cerebellar Cortex - cytology; Cerebellum; Cluster analysis; Cognition; Cortex; Coupling (molecular); Electrophysiology; Excitability; Female; Gene expression; Gene Expression Profiling; Humanities and Social Sciences; Humans; Interneurons; Interneurons - classification; Interneurons - cytology; Interneurons - metabolism; Male; Mice; Mice, Inbred C57BL; Morphology; Motor skill learning; multidisciplinary; Neuroglia - classification; Neuroglia - cytology; Neuroglia - metabolism; Neurons - classification; Neurons - cytology; Neurons - metabolism; Purkinje cells; Science; Science (multidisciplinary); Specialization; Thickness; Transcription; Transcriptome; Unipolar brush cells; Variation

The cerebellar cortex is a well-studied brain structure with diverse roles in motor learning, coordination, cognition and autonomic regulation. However,  a complete inventory of cerebellar cell types is currently lacking. Here, using recent advances in high-throughput transcriptional profiling 1 – 3...