Evolutionary genomic relationships and coupling in MK-STYX and STYX pseudophosphatases

• Published in: Scientific reports Vol. 12; no. 1; p. 4139
• Main Authors: Qi, Yi, Kuang, Di, Kelley, Kylan, Buchser, William J., Hinton, Shantá D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.03.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/181; 631/208; 631/337; 631/45; Computer applications; Dual-Specificity Phosphatases - genetics; Dual-Specificity Phosphatases - metabolism; Evolutionary conservation; Homology; Humanities and Social Sciences; Kinases; MAP kinase; MAP kinase phosphatase; Mitogen-Activated Protein Kinases - genetics; multidisciplinary; Phosphatase; Phosphoserine; Phylogeny; Protein kinase; Proteins; Rhodanese; Science; Science (multidisciplinary); Species; Threonine; Threonine - genetics; Tyrosine - metabolism

The dual specificity phosphatase (DUSP) family has catalytically inactive members, called pseudophosphatases. They have mutations in their catalytic motifs that render them enzymatically inactive. This study analyzes the significance of two pseudophosphatases, MK-STYX [MAPK (mitogen-activated protei...