Serum syndecan-1 reflects organ dysfunction in critically ill patients

• Published in: Scientific reports Vol. 11; no. 1; pp. 8864 - 9
• Main Authors: Suzuki, Keiko, Okada, Hideshi, Sumi, Kazuyuki, Tomita, Hiroyuki, Kobayashi, Ryo, Ishihara, Takuma, Kakino, Yoshinori, Suzuki, Kodai, Yoshiyama, Naomasa, Yasuda, Ryu, Kitagawa, Yuichiro, Fukuta, Tetsuya, Miyake, Takahito, Okamoto, Haruka, Doi, Tomoaki, Yoshida, Takahiro, Yoshida, Shozo, Ogura, Shinji, Suzuki, Akio
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.04.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 639/705/531; 692/308/53/2423; 692/53; Alanine; Alanine transaminase; Antithrombin; Aortic dissection; Aspartate aminotransferase; Biomarkers; Blood; Cardiac arrhythmia; Creatinine; Degradation products; E coli; Fibrin; Heart failure; Heatstroke; Heparan sulfate; Humanities and Social Sciences; Hypoglycemia; Inflammation; Kidneys; Laboratories; Liver diseases; Mortality; multidisciplinary; Patients; Risk factors; Science; Science (multidisciplinary); Sepsis; Severe acute respiratory syndrome coronavirus 2; Syndecan; Transaminase; Trauma; Urea

Syndecan-1 (SDC-1) is found in the endothelial glycocalyx and shed into the blood during systemic inflammatory conditions. We investigated organ dysfunction associated with changing serum SDC-1 levels for early detection of organ dysfunction in critically ill patients. To evaluate the effect of SDC-...