Interferon regulatory factor 8 governs myeloid cell development

• Published in: Cytokine & growth factor reviews Vol. 55; pp. 48 - 57
• Main Authors: Xia, Xueli, Wang, Wenxin, Yin, Kai, Wang, Shengjun
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2020
• Subjects: Advanced Basic Science; Development; Interferon regulatory factors 8; Myeloid cells; Transcription factors; RANKL; Transcription factors; DBD; MHC; AP-1; CDP; AICE; SLAMF; GM-CSF; MDP; mTOR; Development; HSC; iNOS; Th cell; TRIM21; AML; Myeloid cells; cDC; ICSBP; IL; MP; SUMO; H3K4me1; EICE; MS; EAE; GMP; G-CSF; IAD; MZ; IECS; SENP1; CMoP; iPS cell; PMN-MDSCs; CXCR; IRF; Ig; HDAC; C/EBP; CNS; NFATc1; M-MDSCs; NLRC4; ChIP; LPS; IFN; OA; TDF; BAMs; Interferon regulatory factors 8; ISGF3; VEGF; GP; KLF4; CP; pDC; BATF; Pre-BMPs; NAIPs; MDSCs; STAT; TF; CCR; APC; TNF-α; MH2; EIRE; DNMT3b; BAX; TGF-β1; ZICE; TLRs; DC; ISRE; RBP-J; transcription factor; granulocyte colony-stimulating factor; major histocompatibility complex; T helper cell; experimental autoimmune encephalomyelitis; BCL2-Associated X; common monocyte progenitors; IFN-stimulated gene factor 3; zinc finger–IRF composite element; DNA binding domain; central nervous system; chromatin immune-precipitation; ETS-IRF composite element; macrophage-DC progenitor; lipopolysaccharide; granulocyte and macrophage progenitor cell; dendritic cell; osteoarthritis; plasmacytoid dendritic cell; mammalian target of rapamycin; Krüppel-like family 4; monocyte progenitor; NLR family apoptosis inhibitory proteins; multiple sclerosis; myeloid-derived suppressor cells; CCAAT/enhancer binding protein; choroid plexus; type I interferon; granulocyte progenitor; induced pluripotent stem cell; small ubiquitin-like modifier; tumor necrosis factor-α; antigen presenting cell; B cell activating transcription factor; transcription factors; hematopoietic stem cell; prebasophils and mast cell progenitors; activator protein 1; transforming growth factor-β1; surface-expressed signaling lymphocyte activation molecule family member; interferon regulatory factors 8; development; conventional dendritic cell; myeloid cells; border-associated macrophages; chemokine receptor; IRF association domain; nuclear factor of activated T-cells, cytoplasmic 1; NLR Family CARD Domain Containing 4; granulocyte-macrophage colony-stimulating factor; interferon regulatory factor; monocytic myeloid-derived suppressor cells; tumor derived factor; marginal zone; recombination signal binding protein for immunoglobulin kappa J region; mad-homology2; receptor activator of nuclear factor-κB ligand; inducible nitric oxide synthase; signal transducers and activators of transcription; acute myeloid leukemia; IRF-ETS composite sequence; Toll-like receptors; ETS-IRF response element; interleukin; immunoglobulin; histone deacetylase; tripartite motif-containing protein 21; C-X-C chemokine receptor; DNA methyltransferase enzyme3b; interferon consensus sequence binding protein; sentrin-specific peptidase 1; AP-1-IRF composite element; vascular endothelial growth factor; polymorphonuclear myeloid-derived suppressor cells; common dendritic cell progenitor; trimethylation of lysine 4 on histone H1 protein subunit; IFN-stimulated response element
• DOI: 10.1016/j.cytogfr.2020.03.003
• ISSN: 1359-6101

[Display omitted] •IRF8 is composed of the N-terminal region which is a helix-turn-helix DNA binding domain, and C-terminal IRF association domain.•IRF8 controls the lineage specification of dendritic cells and monocyte/macrophage development.•IRF8 is a negative regulator of MDSCs and involved in neoplasia deterioration.•Using or developing specific targeted therapies for IRF8 may contribute to the treatment and prognosis of immune disorders. Interferon regulatory factors (IRFs) are a family of central transcriptional regulators that produce type I interferon and regulate innate and adaptive immune responses. Interferon regulatory factor 8 (IRF8) exists mainly in hematopoietic cells and is essential for the development of several myeloid lineages, including monocytes/macrophages and dendritic cells. In recent years, an increasing number of studies have focused on the roles of IRF8 in the differentiation of myeloid pedigree and MDSC aggregation in diseases such as tumors. In this review, we provide a comprehensive overview of the roles of IRF8 in the regulation of myeloid cell development, with particular reference to multiple disease conditions. Clarifying the various functions of IRF8 may suggest targets for therapeutic interventions.