Intra-arterial transplantation of stem cells in large animals as a minimally-invasive strategy for the treatment of disseminated neurodegeneration

• Published in: Scientific reports Vol. 11; no. 1; pp. 6581 - 10
• Main Authors: Malysz-Cymborska, Izabela, Golubczyk, Dominika, Kalkowski, Lukasz, Kwiatkowska, Joanna, Zawadzki, Michal, Głodek, Joanna, Holak, Piotr, Sanford, Joanna, Milewska, Kamila, Adamiak, Zbigniew, Walczak, Piotr, Janowski, Miroslaw
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378; 631/378/1687; 631/378/1689; 631/378/2183; Amyotrophic lateral sclerosis; Animal diseases; Animal models; Central nervous system diseases; Dogs; Gene expression; Glial stem cells; Histopathology; Humanities and Social Sciences; Inflammation; Iron oxides; Magnetic resonance imaging; Mesenchyme; multidisciplinary; Nanoparticles; Neurodegeneration; Neurodegenerative diseases; Neurological diseases; Science; Science (multidisciplinary); Spinal cord; Stem cell transplantation; Stem cells; Transplantation

Stem cell transplantation proved promising in animal models of neurological diseases; however, in conditions with disseminated pathology such as ALS, delivery of cells and their broad distribution is challenging. To address this problem, we explored intra-arterial (IA) delivery route, of stem cells....