Characterization of host factors associated with the internal ribosomal entry sites of foot-and-mouth disease and classical swine fever viruses

• Published in: Scientific reports Vol. 12; no. 1; pp. 6709 - 11
• Main Authors: Ide, Yutaro, Kitab, Bouchra, Ito, Nobumasa, Okamoto, Riai, Tamura, Yui, Matsui, Takafumi, Sakoda, Yoshihiro, Tsukiyama-Kohara, Kyoko
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 5' Untranslated regions; 631/326; 631/337; Animals; Antiviral activity; Antiviral drugs; Cell lines; Classical Swine Fever; Classical Swine Fever Virus - genetics; Classical Swine Fever Virus - metabolism; Fever; Foot & mouth disease; Foot-and-Mouth Disease; Foot-and-Mouth Disease Virus - genetics; Genomes; Hog cholera; Humanities and Social Sciences; Internal Ribosome Entry Sites; Kidney diseases; multidisciplinary; Peptidase; Polycystic kidney; Pycnogenol; Science; Science (multidisciplinary); siRNA; Swine; Ubiquitin; Viruses

Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal ribosomal entry site (IRES) element within their 5′-untranslated regions. To investigate the common host factors associated with these IRESs, we established c...