Characterization of host factors associated with the internal ribosomal entry sites of foot-and-mouth disease and classical swine fever viruses
Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal ribosomal entry site (IRES) element within their 5′-untranslated regions. To investigate the common host factors associated with these IRESs, we established c...
Saved in:
| Published in | Scientific reports Vol. 12; no. 1; pp. 6709 - 11 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
25.04.2022
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal ribosomal entry site (IRES) element within their 5′-untranslated regions. To investigate the common host factors associated with these IRESs, we established cell lines expressing a bicistronic luciferase reporter plasmid containing an FMDV-IRES or CSFV-IRES element between the
Renilla
and firefly luciferase genes. First, we treated FMDV-IRES cells with the French maritime pine extract, Pycnogenol (PYC), and examined its suppressive effect on FMDV-IRES activity, as PYC has been reported to have antiviral properties. Next, we performed microarray analysis to identify the host factors that modified their expression upon treatment with PYC, and confirmed their function using specific siRNAs. We found that polycystic kidney disease 1-like 3 (PKD1L3) and ubiquitin-specific peptidase 31 (USP31) were associated with FMDV-IRES activity. Moreover, silencing of these factors significantly suppressed CSFV-IRES activity. Thus, PKD1L3 and USP31 are host factors associated with the functions of FMDV- and CSFV-IRES elements. |
|---|---|
| AbstractList | Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal ribosomal entry site (IRES) element within their 5′-untranslated regions. To investigate the common host factors associated with these IRESs, we established cell lines expressing a bicistronic luciferase reporter plasmid containing an FMDV-IRES or CSFV-IRES element between the
Renilla
and firefly luciferase genes. First, we treated FMDV-IRES cells with the French maritime pine extract, Pycnogenol (PYC), and examined its suppressive effect on FMDV-IRES activity, as PYC has been reported to have antiviral properties. Next, we performed microarray analysis to identify the host factors that modified their expression upon treatment with PYC, and confirmed their function using specific siRNAs. We found that polycystic kidney disease 1-like 3 (PKD1L3) and ubiquitin-specific peptidase 31 (USP31) were associated with FMDV-IRES activity. Moreover, silencing of these factors significantly suppressed CSFV-IRES activity. Thus, PKD1L3 and USP31 are host factors associated with the functions of FMDV- and CSFV-IRES elements. Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal ribosomal entry site (IRES) element within their 5'-untranslated regions. To investigate the common host factors associated with these IRESs, we established cell lines expressing a bicistronic luciferase reporter plasmid containing an FMDV-IRES or CSFV-IRES element between the Renilla and firefly luciferase genes. First, we treated FMDV-IRES cells with the French maritime pine extract, Pycnogenol (PYC), and examined its suppressive effect on FMDV-IRES activity, as PYC has been reported to have antiviral properties. Next, we performed microarray analysis to identify the host factors that modified their expression upon treatment with PYC, and confirmed their function using specific siRNAs. We found that polycystic kidney disease 1-like 3 (PKD1L3) and ubiquitin-specific peptidase 31 (USP31) were associated with FMDV-IRES activity. Moreover, silencing of these factors significantly suppressed CSFV-IRES activity. Thus, PKD1L3 and USP31 are host factors associated with the functions of FMDV- and CSFV-IRES elements. Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal ribosomal entry site (IRES) element within their 5'-untranslated regions. To investigate the common host factors associated with these IRESs, we established cell lines expressing a bicistronic luciferase reporter plasmid containing an FMDV-IRES or CSFV-IRES element between the Renilla and firefly luciferase genes. First, we treated FMDV-IRES cells with the French maritime pine extract, Pycnogenol (PYC), and examined its suppressive effect on FMDV-IRES activity, as PYC has been reported to have antiviral properties. Next, we performed microarray analysis to identify the host factors that modified their expression upon treatment with PYC, and confirmed their function using specific siRNAs. We found that polycystic kidney disease 1-like 3 (PKD1L3) and ubiquitin-specific peptidase 31 (USP31) were associated with FMDV-IRES activity. Moreover, silencing of these factors significantly suppressed CSFV-IRES activity. Thus, PKD1L3 and USP31 are host factors associated with the functions of FMDV- and CSFV-IRES elements.Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal ribosomal entry site (IRES) element within their 5'-untranslated regions. To investigate the common host factors associated with these IRESs, we established cell lines expressing a bicistronic luciferase reporter plasmid containing an FMDV-IRES or CSFV-IRES element between the Renilla and firefly luciferase genes. First, we treated FMDV-IRES cells with the French maritime pine extract, Pycnogenol (PYC), and examined its suppressive effect on FMDV-IRES activity, as PYC has been reported to have antiviral properties. Next, we performed microarray analysis to identify the host factors that modified their expression upon treatment with PYC, and confirmed their function using specific siRNAs. We found that polycystic kidney disease 1-like 3 (PKD1L3) and ubiquitin-specific peptidase 31 (USP31) were associated with FMDV-IRES activity. Moreover, silencing of these factors significantly suppressed CSFV-IRES activity. Thus, PKD1L3 and USP31 are host factors associated with the functions of FMDV- and CSFV-IRES elements. Abstract Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal ribosomal entry site (IRES) element within their 5′-untranslated regions. To investigate the common host factors associated with these IRESs, we established cell lines expressing a bicistronic luciferase reporter plasmid containing an FMDV-IRES or CSFV-IRES element between the Renilla and firefly luciferase genes. First, we treated FMDV-IRES cells with the French maritime pine extract, Pycnogenol (PYC), and examined its suppressive effect on FMDV-IRES activity, as PYC has been reported to have antiviral properties. Next, we performed microarray analysis to identify the host factors that modified their expression upon treatment with PYC, and confirmed their function using specific siRNAs. We found that polycystic kidney disease 1-like 3 (PKD1L3) and ubiquitin-specific peptidase 31 (USP31) were associated with FMDV-IRES activity. Moreover, silencing of these factors significantly suppressed CSFV-IRES activity. Thus, PKD1L3 and USP31 are host factors associated with the functions of FMDV- and CSFV-IRES elements. |
| ArticleNumber | 6709 |
| Author | Sakoda, Yoshihiro Tsukiyama-Kohara, Kyoko Okamoto, Riai Tamura, Yui Kitab, Bouchra Ide, Yutaro Ito, Nobumasa Matsui, Takafumi |
| Author_xml | – sequence: 1 givenname: Yutaro surname: Ide fullname: Ide, Yutaro organization: Transboundary Animal Disease Center, Joint Faculty of Veterinary Medicine, Kagoshima University – sequence: 2 givenname: Bouchra surname: Kitab fullname: Kitab, Bouchra organization: Transboundary Animal Disease Center, Joint Faculty of Veterinary Medicine, Kagoshima University – sequence: 3 givenname: Nobumasa surname: Ito fullname: Ito, Nobumasa organization: Transboundary Animal Disease Center, Joint Faculty of Veterinary Medicine, Kagoshima University – sequence: 4 givenname: Riai surname: Okamoto fullname: Okamoto, Riai organization: Transboundary Animal Disease Center, Joint Faculty of Veterinary Medicine, Kagoshima University – sequence: 5 givenname: Yui surname: Tamura fullname: Tamura, Yui organization: Transboundary Animal Disease Center, Joint Faculty of Veterinary Medicine, Kagoshima University – sequence: 6 givenname: Takafumi surname: Matsui fullname: Matsui, Takafumi organization: Transboundary Animal Disease Center, Joint Faculty of Veterinary Medicine, Kagoshima University – sequence: 7 givenname: Yoshihiro surname: Sakoda fullname: Sakoda, Yoshihiro organization: Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University – sequence: 8 givenname: Kyoko surname: Tsukiyama-Kohara fullname: Tsukiyama-Kohara, Kyoko email: kkohara@vet.kagoshima-u.ac.jp organization: Transboundary Animal Disease Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35468926$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ks1uEzEUhUeoiJbSF2CBLLFhM-Dxz4y9QUIRhUqV2MDacuzrxNHELrYnVfMSfeU6SSltF_VmrDvnfL7XPm-boxADNM37Dn_uMBVfMuu4FC0mpO0wo0O7fdWcEMx4SyghR4_2x81ZzitcFyeSdfJNc0w564Uk_UlzO1vqpE2B5Le6-BhQdGgZc0GuVmPKSOccjdcFLLr2ZYnKEpAP1RD0iJKfxxzXdQehpBuUfYG8Q7gYS6uDbddxqibrM-gMqFaQGSvSm-rJ1z4AcrCBhDY-TRnyu-a102OGs_vvafPn_Pvv2c_28tePi9m3y9ZwhkvLBiddnaCjVshB98TUSSW1RMztwEACBSBzI6y0DJO5xELwAQxxxmJqB0pPm4sD10a9UlfJr3W6UVF7tS_EtFA6FW9GUM5ySTtpnGOCOSJ0x7WwnGDTETkYWVlfD6yrab4Ga3ZXoccn0Kd_gl-qRdwoianE_VABn-4BKf6dIBe19tnAOOoAccqK9JzznvaSV-nHZ9JVnHZPsVcxKYgUO9WHxx09tPLv3auAHAQmxZwTuAdJh9UuX-qQL1Xzpfb5UttqEs9Mxpd9aOpUfnzZSg_WXM8JC0j_237BdQd0iOgp |
| CitedBy_id | crossref_primary_10_1016_j_virusres_2023_199244 crossref_primary_10_1186_s12896_023_00805_6 crossref_primary_10_1128_mbio_00358_23 |
| Cites_doi | 10.1080/10855660310001638197 10.1155/2010/458927 10.1096/fj.10-162925 10.1099/vir.0.040386-0 10.1002/wrna.1268 10.1128/JVI.00346-12 10.1038/sj.emboj.7601549 10.1016/s0928-0197(98)00037-3 10.1186/s12917-016-0694-8 10.1093/chemse/bjq070 10.1128/jvi.66.3.1476-1483.1992 10.1038/nm1268 10.1128/JVI.00551-12 10.3390/pathogens9030188 10.1073/pnas.0602702103 10.1016/j.ijantimicag.2020.106191 10.1371/journal.pgen.1002898 10.1038/90968 10.1186/1297-9716-44-116 10.1016/j.celrep.2015.09.041 10.1038/nature12658 10.1128/JVI.01191-19 10.1007/s00705-011-1043-7 10.1016/j.bbrc.2019.03.099 10.1016/j.cardfail.2007.06.721 10.1099/vir.0.19063-0 10.1002/pmic.200800338 10.1016/j.antiviral.2014.10.017 10.1016/j.cellsig.2005.03.017 10.1007/s11262-019-01696-6 10.7883/yoken.JJID.2008.279 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2022 2022. The Author(s). The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2022 – notice: 2022. The Author(s). – notice: The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU COVID DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
| DOI | 10.1038/s41598-022-10437-z |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College Coronavirus Research Database ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection PML(ProQuest Medical Library) Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition Coronavirus Research Database ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| EndPage | 11 |
| ExternalDocumentID | oai_doaj_org_article_fd59319cff484f28a15a8d520c1297c9 PMC9039067 35468926 10_1038_s41598_022_10437_z |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: The Ministry of Education, Science, and Culture, Japan grantid: 20H3164 – fundername: ; grantid: 20H3164 |
| GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFPKN CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM 7XB 8FK AARCD COVID K9. PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS Q9U 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c540t-47f9f89213d897a62c23293d28bd74e9e3ee2bc8d9d402b908857ec2fcd03d733 |
| IEDL.DBID | M48 |
| ISSN | 2045-2322 |
| IngestDate | Wed Aug 27 01:26:14 EDT 2025 Thu Aug 21 14:33:38 EDT 2025 Fri Jul 11 06:38:17 EDT 2025 Wed Aug 13 08:18:40 EDT 2025 Thu Apr 03 06:58:14 EDT 2025 Thu Apr 24 22:59:49 EDT 2025 Tue Jul 01 04:16:17 EDT 2025 Fri Feb 21 02:39:30 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | 2022. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c540t-47f9f89213d897a62c23293d28bd74e9e3ee2bc8d9d402b908857ec2fcd03d733 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41598-022-10437-z |
| PMID | 35468926 |
| PQID | 2654982985 |
| PQPubID | 2041939 |
| PageCount | 11 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_fd59319cff484f28a15a8d520c1297c9 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9039067 proquest_miscellaneous_2655563695 proquest_journals_2654982985 pubmed_primary_35468926 crossref_primary_10_1038_s41598_022_10437_z crossref_citationtrail_10_1038_s41598_022_10437_z springer_journals_10_1038_s41598_022_10437_z |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2022-04-25 |
| PublicationDateYYYYMMDD | 2022-04-25 |
| PublicationDate_xml | – month: 04 year: 2022 text: 2022-04-25 day: 25 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2022 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Ishimaru (CR22) 2010; 24 Burks, Zwieb, Muller, Wower, Wower (CR3) 2011; 156 Nelson (CR27) 2010; 35 Matsumori, Higuchi, Shimada (CR11) 2007; 13 Friis, Rasmussen, Belsham (CR20) 2012; 86 Weichmann, Rohdewald (CR21) 2020; 56 Feng (CR12) 2008; 61 Kashyap (CR28) 2019; 512 Tetsuo (CR18) 2020 Khawaja, Vopalensky, Pospisek (CR6) 2015; 6 Yokoyama (CR31) 2012; 8 Hu, Liu, Wu, Liu (CR29) 2015; 13 Pacheco, Martinez-Salas (CR10) 2010; 2010 Wakita (CR24) 2005; 11 Mercer (CR25) 2001; 7 Ishimaru (CR26) 2006; 103 Tzimas (CR30) 2006; 18 Pacheco, Reigadas, Martinez-Salas (CR9) 2008; 8 Ezzikouri (CR13) 2015; 113 Licursi, Komatsu, Pongnopparat, Hirasawa (CR19) 2012; 93 Kanda, Ozawa, Tsukiyama-Kohara (CR14) 2016; 12 Jamal, Belsham (CR1) 2013; 44 Tamura (CR16) 2019 Tautz, Meyers, Thiel (CR2) 1998; 10 Locker, Easton, Lukavsky (CR8) 2007; 26 Matsui, Handa, Kanda, Tsukiyama-Kohara (CR15) 2019; 55 Reusken, Dalebout, Eerligh, Bredenbeek, Spaan (CR4) 2003; 84 Hashem (CR7) 2013; 503 Tsukiyama-Kohara, Iizuka, Kohara, Nomoto (CR5) 1992; 66 Tamura (CR17) 2012; 86 Lockhart (CR23) 2004; 15 JM Burks (10437_CR3) 2011; 156 N Tautz (10437_CR2) 1998; 10 T Tamura (10437_CR17) 2012; 86 N Locker (10437_CR8) 2007; 26 A Pacheco (10437_CR9) 2008; 8 C Tzimas (10437_CR30) 2006; 18 JS Yokoyama (10437_CR31) 2012; 8 C Reusken (10437_CR4) 2003; 84 F Weichmann (10437_CR21) 2020; 56 TM Nelson (10437_CR27) 2010; 35 SM Jamal (10437_CR1) 2013; 44 P Kashyap (10437_CR28) 2019; 512 M Licursi (10437_CR19) 2012; 93 MB Friis (10437_CR20) 2012; 86 T Matsui (10437_CR15) 2019; 55 A Khawaja (10437_CR6) 2015; 6 A Matsumori (10437_CR11) 2007; 13 M Tetsuo (10437_CR18) 2020 M Hu (10437_CR29) 2015; 13 WY Feng (10437_CR12) 2008; 61 A Pacheco (10437_CR10) 2010; 2010 Y Ishimaru (10437_CR26) 2006; 103 K Tsukiyama-Kohara (10437_CR5) 1992; 66 T Tamura (10437_CR16) 2019 DF Mercer (10437_CR25) 2001; 7 S Ezzikouri (10437_CR13) 2015; 113 T Kanda (10437_CR14) 2016; 12 PJ Lockhart (10437_CR23) 2004; 15 Y Ishimaru (10437_CR22) 2010; 24 Y Hashem (10437_CR7) 2013; 503 T Wakita (10437_CR24) 2005; 11 |
| References_xml | – volume: 15 start-page: 9 year: 2004 end-page: 14 ident: CR23 article-title: Identification of the human ubiquitin specific protease 31 (USP31) gene: Structure, sequence and expression analysis publication-title: DNA Seq. doi: 10.1080/10855660310001638197 – volume: 2010 year: 2010 ident: CR10 article-title: Insights into the biology of IRES elements through riboproteomic approaches publication-title: J. Biomed. Biotechnol. doi: 10.1155/2010/458927 – volume: 61 start-page: 279 year: 2008 end-page: 285 ident: CR12 article-title: Pycnogenol, a procyanidin-rich extract from French maritime pine, inhibits intracellular replication of HIV-1 as well as its binding to host cells publication-title: Jpn. J. Infect. Dis. – volume: 24 start-page: 4058 year: 2010 end-page: 4067 ident: CR22 article-title: Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae publication-title: FASEB J. doi: 10.1096/fj.10-162925 – volume: 93 start-page: 951 year: 2012 end-page: 962 ident: CR19 article-title: Promotion of viral internal ribosomal entry site-mediated translation under amino acid starvation publication-title: J. Gen. Virol. doi: 10.1099/vir.0.040386-0 – volume: 6 start-page: 211 year: 2015 end-page: 224 ident: CR6 article-title: Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and function publication-title: Wiley Interdiscip. Rev. RNA doi: 10.1002/wrna.1268 – volume: 86 start-page: 8681 year: 2012 end-page: 8692 ident: CR20 article-title: Modulation of translation initiation efficiency in classical swine fever virus publication-title: J. Virol. doi: 10.1128/JVI.00346-12 – volume: 26 start-page: 795 year: 2007 end-page: 805 ident: CR8 article-title: HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly publication-title: EMBO J. doi: 10.1038/sj.emboj.7601549 – volume: 10 start-page: 121 year: 1998 end-page: 127 ident: CR2 article-title: Pathogenesis of mucosal disease, a deadly disease of cattle caused by a pestivirus publication-title: Clin. Diagn. Virol. doi: 10.1016/s0928-0197(98)00037-3 – volume: 12 start-page: 66 year: 2016 ident: CR14 article-title: IRES-mediated translation of foot-and-mouth disease virus (FMDV) in cultured cells derived from FMDV-susceptible and -insusceptible animals publication-title: BMC Vet. Res. doi: 10.1186/s12917-016-0694-8 – volume: 35 start-page: 565 year: 2010 end-page: 577 ident: CR27 article-title: Taste function in mice with a targeted mutation of the pkd1l3 gene publication-title: Chem. Senses doi: 10.1093/chemse/bjq070 – volume: 66 start-page: 1476 year: 1992 end-page: 1483 ident: CR5 article-title: Internal ribosome entry site within hepatitis C virus RNA publication-title: J. Virol. doi: 10.1128/jvi.66.3.1476-1483.1992 – volume: 11 start-page: 791 year: 2005 end-page: 796 ident: CR24 article-title: Production of infectious hepatitis C virus in tissue culture from a cloned viral genome publication-title: Nat. Med. doi: 10.1038/nm1268 – volume: 86 start-page: 8602 year: 2012 end-page: 8613 ident: CR17 article-title: Selection of classical swine fever virus with enhanced pathogenicity reveals synergistic virulence determinants in E2 and NS4B publication-title: J. Virol. doi: 10.1128/JVI.00551-12 – year: 2020 ident: CR18 article-title: Development of a high-throughput serum neutralization test using recombinant pestiviruses possessing a small reporter tag publication-title: Pathogens. doi: 10.3390/pathogens9030188 – volume: 103 start-page: 12569 year: 2006 end-page: 12574 ident: CR26 article-title: Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0602702103 – volume: 56 year: 2020 ident: CR21 article-title: Projected supportive effects of Pycnogenol in patients suffering from multi-dimensional health impairments after a SARS-CoV2 infection publication-title: Int. J. Antimicrob. Agents doi: 10.1016/j.ijantimicag.2020.106191 – volume: 8 year: 2012 ident: CR31 article-title: Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1002898 – volume: 7 start-page: 927 year: 2001 end-page: 933 ident: CR25 article-title: Hepatitis C virus replication in mice with chimeric human livers publication-title: Nat. Med. doi: 10.1038/90968 – volume: 44 start-page: 116 year: 2013 ident: CR1 article-title: Foot-and-mouth disease: Past, present and future publication-title: Vet. Res. doi: 10.1186/1297-9716-44-116 – volume: 13 start-page: 798 year: 2015 end-page: 811 ident: CR29 article-title: Influx-operated Ca(2+) entry via PKD2-L1 and PKD1-L3 channels facilitates sensory responses to polymodal transient stimuli publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.09.041 – volume: 503 start-page: 539 year: 2013 end-page: 543 ident: CR7 article-title: Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit publication-title: Nature doi: 10.1038/nature12658 – year: 2019 ident: CR16 article-title: In vivo dynamics of reporter Flaviviridae viruses publication-title: J. Virol. doi: 10.1128/JVI.01191-19 – volume: 156 start-page: 1737 year: 2011 end-page: 1747 ident: CR3 article-title: In silico analysis of IRES RNAs of foot-and-mouth disease virus and related picornaviruses publication-title: Adv. Virol. doi: 10.1007/s00705-011-1043-7 – volume: 512 start-page: 812 year: 2019 end-page: 818 ident: CR28 article-title: A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2019.03.099 – volume: 13 start-page: 785 year: 2007 end-page: 791 ident: CR11 article-title: French maritime pine bark extract inhibits viral replication and prevents development of viral myocarditis publication-title: J. Card. Fail. doi: 10.1016/j.cardfail.2007.06.721 – volume: 84 start-page: 1761 year: 2003 end-page: 1769 ident: CR4 article-title: Analysis of hepatitis C virus/classical swine fever virus chimeric 5'NTRs: Sequences within the hepatitis C virus IRES are required for viral RNA replication publication-title: J. Gen. Virol. doi: 10.1099/vir.0.19063-0 – volume: 8 start-page: 4782 year: 2008 end-page: 4790 ident: CR9 article-title: Riboproteomic analysis of polypeptides interacting with the internal ribosome-entry site element of foot-and-mouth disease viral RNA publication-title: Proteomics doi: 10.1002/pmic.200800338 – volume: 113 start-page: 93 year: 2015 end-page: 102 ident: CR13 article-title: Inhibitory effects of Pycnogenol(R) on hepatitis C virus replication publication-title: Antiviral Res. doi: 10.1016/j.antiviral.2014.10.017 – volume: 18 start-page: 83 year: 2006 end-page: 92 ident: CR30 article-title: Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB publication-title: Cell Signal doi: 10.1016/j.cellsig.2005.03.017 – volume: 55 start-page: 786 year: 2019 end-page: 794 ident: CR15 article-title: Silencing of the foot-and-mouth disease virus internal ribosomal entry site by targeting relatively conserved region among serotypes publication-title: Virus Genes doi: 10.1007/s11262-019-01696-6 – volume: 12 start-page: 66 year: 2016 ident: 10437_CR14 publication-title: BMC Vet. Res. doi: 10.1186/s12917-016-0694-8 – volume: 26 start-page: 795 year: 2007 ident: 10437_CR8 publication-title: EMBO J. doi: 10.1038/sj.emboj.7601549 – volume: 10 start-page: 121 year: 1998 ident: 10437_CR2 publication-title: Clin. Diagn. Virol. doi: 10.1016/s0928-0197(98)00037-3 – year: 2019 ident: 10437_CR16 publication-title: J. Virol. doi: 10.1128/JVI.01191-19 – volume: 86 start-page: 8602 year: 2012 ident: 10437_CR17 publication-title: J. Virol. doi: 10.1128/JVI.00551-12 – volume: 15 start-page: 9 year: 2004 ident: 10437_CR23 publication-title: DNA Seq. doi: 10.1080/10855660310001638197 – volume: 103 start-page: 12569 year: 2006 ident: 10437_CR26 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0602702103 – volume: 156 start-page: 1737 year: 2011 ident: 10437_CR3 publication-title: Adv. Virol. doi: 10.1007/s00705-011-1043-7 – volume: 86 start-page: 8681 year: 2012 ident: 10437_CR20 publication-title: J. Virol. doi: 10.1128/JVI.00346-12 – volume: 13 start-page: 798 year: 2015 ident: 10437_CR29 publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.09.041 – volume: 6 start-page: 211 year: 2015 ident: 10437_CR6 publication-title: Wiley Interdiscip. Rev. RNA doi: 10.1002/wrna.1268 – volume: 61 start-page: 279 year: 2008 ident: 10437_CR12 publication-title: Jpn. J. Infect. Dis. doi: 10.7883/yoken.JJID.2008.279 – volume: 55 start-page: 786 year: 2019 ident: 10437_CR15 publication-title: Virus Genes doi: 10.1007/s11262-019-01696-6 – volume: 35 start-page: 565 year: 2010 ident: 10437_CR27 publication-title: Chem. Senses doi: 10.1093/chemse/bjq070 – volume: 44 start-page: 116 year: 2013 ident: 10437_CR1 publication-title: Vet. Res. doi: 10.1186/1297-9716-44-116 – volume: 2010 year: 2010 ident: 10437_CR10 publication-title: J. Biomed. Biotechnol. doi: 10.1155/2010/458927 – volume: 24 start-page: 4058 year: 2010 ident: 10437_CR22 publication-title: FASEB J. doi: 10.1096/fj.10-162925 – volume: 8 start-page: 4782 year: 2008 ident: 10437_CR9 publication-title: Proteomics doi: 10.1002/pmic.200800338 – volume: 18 start-page: 83 year: 2006 ident: 10437_CR30 publication-title: Cell Signal doi: 10.1016/j.cellsig.2005.03.017 – volume: 84 start-page: 1761 year: 2003 ident: 10437_CR4 publication-title: J. Gen. Virol. doi: 10.1099/vir.0.19063-0 – volume: 13 start-page: 785 year: 2007 ident: 10437_CR11 publication-title: J. Card. Fail. doi: 10.1016/j.cardfail.2007.06.721 – volume: 56 year: 2020 ident: 10437_CR21 publication-title: Int. J. Antimicrob. Agents doi: 10.1016/j.ijantimicag.2020.106191 – volume: 8 year: 2012 ident: 10437_CR31 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1002898 – volume: 503 start-page: 539 year: 2013 ident: 10437_CR7 publication-title: Nature doi: 10.1038/nature12658 – volume: 66 start-page: 1476 year: 1992 ident: 10437_CR5 publication-title: J. Virol. doi: 10.1128/jvi.66.3.1476-1483.1992 – volume: 113 start-page: 93 year: 2015 ident: 10437_CR13 publication-title: Antiviral Res. doi: 10.1016/j.antiviral.2014.10.017 – year: 2020 ident: 10437_CR18 publication-title: Pathogens. doi: 10.3390/pathogens9030188 – volume: 7 start-page: 927 year: 2001 ident: 10437_CR25 publication-title: Nat. Med. doi: 10.1038/90968 – volume: 11 start-page: 791 year: 2005 ident: 10437_CR24 publication-title: Nat. Med. doi: 10.1038/nm1268 – volume: 512 start-page: 812 year: 2019 ident: 10437_CR28 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2019.03.099 – volume: 93 start-page: 951 year: 2012 ident: 10437_CR19 publication-title: J. Gen. Virol. doi: 10.1099/vir.0.040386-0 |
| SSID | ssj0000529419 |
| Score | 2.3782258 |
| Snippet | Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal ribosomal entry... Abstract Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 6709 |
| SubjectTerms | 5' Untranslated regions 631/326 631/337 Animals Antiviral activity Antiviral drugs Cell lines Classical Swine Fever Classical Swine Fever Virus - genetics Classical Swine Fever Virus - metabolism Fever Foot & mouth disease Foot-and-Mouth Disease Foot-and-Mouth Disease Virus - genetics Genomes Hog cholera Humanities and Social Sciences Internal Ribosome Entry Sites Kidney diseases multidisciplinary Peptidase Polycystic kidney Pycnogenol Science Science (multidisciplinary) siRNA Swine Ubiquitin Viruses |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LixQxEA6yIHgR12e7q0TwpmG78-gkR11cFkFPLuwt5IkDu90yPaO4f8K_bCXpGXd8Xrw16XQTUlXUV6nUVwg99ykXnAdBANtbwh2TxHZREuG75FzXB5HyOeS79_3pGX97Ls6vtfrKd8IqPXDduKMUhAY18SlxxRNVthNWBUFbD55K-lK6Bz7vWjBVWb2p5p2eq2Rapo4m8FS5mgxiry7z-ZCrHU9UCPt_hzJ_vSz5U8a0OKKTO-j2jCDxq7ryfXQjDnfRzdpT8us99O14S8FcKyzxmHAu5cBzax1sZ4nEgPMpLAYIiBf1YPACLxdunMZLeCotR3BOLk_5F2kcV8QOgVzmpnt4TuxgGME-I_AsbDx9AdCKUwT7wJ8Xy_UUp_vo7OTNh-NTMnddIB7Q24pwmXRSmnYsKC1tTz2ALs0CVS5IHnVkMVLnVdABYk-X70kJGT0FobcsSMYeoL1hHOIjhHUSwXrvVFSeJ9Za14McpeoiBDIqpgZ1GwkYP1OS584YF6akxpkyVWoGpGaK1MxVg15sv_lUCTn-Ovt1Fux2ZibTLgOgYmZWMfMvFWvQ4UYtzGzhk6E9RNaKaiUa9Gz7GmwzJ1zsEMd1mZP513oNcx5WLdquhAnewy73DZI7-rWz1N03w-Jj4f_WLdMAMhr0cqOJP5b15614_D-24gDdotmEWk6oOER7q-U6PgFUtnJPiwF-B6ZqN4s priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4k2gICNxA6uJH7F9QlBRVUhwotLeIscPWKlNymYXRP8Ef5mZxJtqefQWJU7keGbszzOebwh56RMmnAfFANs7JluhmauiZspXqW2rOqiEfsiPn-rjE_lhoRbZ4TbkY5XbOXGcqEPv0Ud-wGvYyRhujXpz_o1h1SiMruYSGtfJDaQuwyNdeqFnHwtGsWRlc65MKczBAOsV5pTBDqxCVh92sbMejbT9_8Kafx-Z_CNuOi5HR3fI7Ywj6dtJ8HfJtdjdIzenypI_75NfhzMR85RnSftEMaGD5gI71GW5xEDRF0sBCNLl5B48patl2w_9GVyNhUcoDsKAn0h9v2auC-wMS-_RHN6hcId6xOEocjr8AOhKUwQrod-Xq80Qhwfk5Oj958NjlmsvMA8Ybs2kTjYZyysRjNWu5h6glxWBmzZoGW0UMfLWm2AD7EBbPC2ldPQcRF-KoIV4SPa6vouPCbVJBed9a6LxMonStbVPSZsqwnbGxFSQaiuBxmdicqyPcdqMAXJhmklqDUitGaXWXBTk1fzO-UTLcWXrdyjYuSVSao83-tWXJltok4KyMB9B16SRiRtXKWeC4qUHSKS9Lcj-Vi2abOdDc6mVBXkxPwYLxbCL62K_GdsgC1ttoc2jSYvmngglaxjluiB6R792urr7pFt-HVnAbSksQI2CvN5q4mW3_j8UT67-i6fkFkfjKCXjap_srVeb-AxQ17p9PprWb3z0L1g priority: 102 providerName: ProQuest – databaseName: Springer Nature OA Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZKERIXxJtAQUbiBhaJH7F9hBVVhQQnKvVmJX7ASm1SbXZB7Z_oX2bGyQYtFCRuUTKJRp6Z-LPH8w0hr3zCgvOgGGD7hslWaNZUUTPlq9S2VR1Uwn3IT5_ro2P58USd7BG-rYXJh_YzpWX-TW9Ph70dYKLBYjBYOlVIx8Mub5CbSN2OXr2oF_O-CmauZGWn-phSmGte3ZmDMlX_dfjyz2OSv-VK8xR0eJfcmbAjfTdqe4_sxe4-uTV2k7x4QK4WM_nyWFtJ-0SxiINOTXVoM9kiBor7rxTAH12OW4KndLVs-6E_g6vcbIRiWnnAT6S-X7OmC-wM2-3RKaVD4Q71iL3RzHT4AXCVpgiRQb8vV5shDg_J8eGHL4sjNvVbYB5w25pJnWwyllciGKubmnuAW1YEbtqgZbRRxMhbb4INsOps8YSU0tFzMHcpghbiEdnv-i4-IdQmFRrvWxONl0mUTVv7lLSpIixhTEwFqbYWcH4iI8eeGKcuJ8WFcaPVHFjNZau5y4K8nt85H6k4_in9Hg07SyKNdr7Rr766ya1cCsrCPwhUk0YmbppKNSYoXnqAQdrbghxs3cJNsT04XsOa2nBrVEFezo8hKjHV0nSx32QZZF6rLcg8Hr1o1kQoWcMo1wXRO_61o-ruk275LTN_21JYgBcFebP1xF9q_X0onv6f-DNym2OwlJJxdUD216tNfA7Ia92-yKH2E5PVLYg priority: 102 providerName: Springer Nature |
| Title | Characterization of host factors associated with the internal ribosomal entry sites of foot-and-mouth disease and classical swine fever viruses |
| URI | https://link.springer.com/article/10.1038/s41598-022-10437-z https://www.ncbi.nlm.nih.gov/pubmed/35468926 https://www.proquest.com/docview/2654982985 https://www.proquest.com/docview/2655563695 https://pubmed.ncbi.nlm.nih.gov/PMC9039067 https://doaj.org/article/fd59319cff484f28a15a8d520c1297c9 |
| Volume | 12 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED_tQ0i8IL7JGJWReANDY8ex_YBQV22aKm1CQKW-RYk_RqUuYU0LbP8E_zLnJC0qFCSeUjmXyPLd1b_z5X4H8ML4UHBuBUVsn9Ok4JLmsZNUmNgXRZxa4cM55Nl5ejpORhMx2YFVu6NuAeutoV3oJzWez15_v7p-hw7_ti0ZV29q3IRCoRiGVXGg6qE3u7CPO5MMjnrWwf2W65vpJNZd7cz2Rzf2p4bGfxv2_PMTyt_yqM32dHIX7nS4kgxaQ7gHO668D7faTpPXD-DHcE3M3NZdksqTUOBBuoY7JO_05CwJZ7MEgSGZtseFMzKfFlVdXeKvphEJCSnnOrzCV9WC5qWll6EVH-nSPQRHiAm4PJgAqb8hlCXeodeQr9P5snb1QxifHH8antKuFwM1iOkWNJFee6VZzK3SMk-ZQSimuWWqsDJx2nHnWGGU1RYj0iJ8PSWkMwxNoc-t5PwR7JVV6Z4A0V7Y3JhCOWUSz_t5kRrvpYodhjfK-QjilQYy0xGVh34Zs6xJmHOVtVrLUGtZo7XsJoKX62e-tDQd_5Q-CopdSwaK7Wagml9kncdm3gqN_084tUQlnqk8FrmygvUNQiRpdASHK7PIVmabsRTjbcW0EhE8X99Gjw1pmLx01bKRCaxsqUaZx60VrWfCRZLiKqcRyA372pjq5p1y-rlhBdd9rhF6RPBqZYm_pvX3pTj4P_GncJsFZ-knlIlD2FvMl-4ZorJF0YNdOZE92B8MRh9HeD06Pn__AUeH6bDXnHT0Gmf8CeUYPQU |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqVgguiHcDBYwEJ7CaOHZiHxCipdWWtiuEWqm3kPgBK7VJ2exStX-Cf8JvZCavann01luUOJHjefibGc8MIS-Nx4RzKxlg-5yJIk5ZHrmUSRP5oogSKz36IffHyehQfDySR0vkV58Lg8cqe53YKGpbGfSRr_MELBnFtZLvTr8z7BqF0dW-hUbLFrvu_AxMtvrtzgeg7yvOt7cONkes6yrADKCTGROp115pHsVW6TRPuAFQoWPLVWFT4bSLneOFUVZbsK0KPAckU2c4_FQY2xQdoKDyV0QMpswyWdnYGn_6PHh1MG4mIt1l54SxWq9hh8QsNrD5IqwjxC4WdsCmUcC_0O3fhzT_iNQ2G-D2HXK7Q670fctqd8mSK--RG20vy_P75OfmUPq5zeyklaeYQkK7lj407zjBWYreXwrQk05ah-QxnU6Kqq5O4KppdUJx2Wv8hK-qGctLy06w2R_tAkoU7lCDyB-ZjNZnAJapdyCX9MdkOq9d_YAcXgtdHpLlsirdKqHaS5sbUyinjPBxmBeJ8T5VkQMDSjkfkKinQGa6UujYkeM4a0LyscpaqmVAtayhWnYRkNfDO6dtIZArR28gYYeRWMS7uVFNv2adTsi8lRo0IExNKOG5yiOZKyt5aACEpUYHZK1ni6zTLHV2KQcBeTE8Bp2AgZ68dNW8GYN13xINYx61XDTMJJYigVVOApIu8NfCVBeflJNvTd1xHcYawE1A3vSceDmt_y_F46v_4jm5OTrY38v2dsa7T8gtjoISCsblGlmeTefuKWC-WfGsEzRKvly3bP8G1W9tOQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqIhAXxLsLBYwEJ7A2sePYPiAELauWQsWBSnsLiR-wUpuUzS5V-yf4P_w6ZvKqlkdvvUWJEzmeh7-Z8cwQ8swGTDh3kgG2z1lSCMXy2CsmbRyKIk6dDOiH_Lif7hwk76dyukZ-9bkweKyy14mNonaVRR_5mKdgyWhutByH7ljEp-3J6-PvDDtIYaS1b6fRssiePz0B861-tbsNtH7O-eTd560d1nUYYBaQyoIlKpigDY-F00blKbcAMIxwXBdOJd544T0vrHbGgZ1V4Jkgqbzl8IORcAqdoaD-ryghY5QxNVWDfwcjaElsujydSOhxDXsl5rOB9RdjRSF2trIXNi0D_oVz_z6u-UfMttkKJzfJjQ7D0jct090ia768Ta62XS1P75CfW0MR6DbHk1aBYjIJ7Zr70LzjCe8o-oEpgFA6a12Th3Q-K6q6OoKrpukJxUWv8ROhqhYsLx07wrZ_tAstUbhDLdoAyG60PgHYTIMHCaU_ZvNl7eu75OBSqHKPrJdV6TcINUG63NpCe22TIKK8SG0ISsceTCntw4jEPQUy2xVFx94ch1kTnBc6a6mWAdWyhmrZ2Yi8GN45bkuCXDj6LRJ2GInlvJsb1fxr1mmHLDhpQBfC1BKdBK7zWObaSR5ZgGPKmhHZ7Nki63RMnZ1LxIg8HR6DdsCQT176atmMwQpwqYEx91suGmYiZJLCKqcjolb4a2Wqq0_K2bemArmJhAGYMyIve048n9b_l-LBxX_xhFwDic4-7O7vPSTXOcpJlDAuN8n6Yr70jwD8LYrHjZRR8uWyxfo3lU5wCQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Characterization+of+host+factors+associated+with+the+internal+ribosomal+entry+sites+of+foot-and-mouth+disease+and+classical+swine+fever+viruses&rft.jtitle=Scientific+reports&rft.au=Ide%2C+Yutaro&rft.au=Kitab%2C+Bouchra&rft.au=Ito%2C+Nobumasa&rft.au=Okamoto%2C+Riai&rft.date=2022-04-25&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=12&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-022-10437-z&rft.externalDocID=10_1038_s41598_022_10437_z |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |