Passive transfer of Ad26.COV2.S-elicited IgG from humans attenuates SARS-CoV-2 disease in hamsters

• Published in: npj vaccines Vol. 7; no. 1; pp. 2 - 6
• Main Authors: Tostanoski, Lisa H., Chandrashekar, Abishek, Patel, Shivani, Yu, Jingyou, Jacob-Dolan, Catherine, Chang, Aiquan, Powers, Olivia C., Sellers, Daniel, Gardner, Sarah, Barrett, Julia, Sanborn, Owen, Stephenson, Kathryn E., Ansel, Jessica L., Jaegle, Kate, Seaman, Michael S., Porto, Maciel, Lok, Megan, Spence, Brittany, Cayer, Kathleen, Nase, Danielle, Holman, Shaikim, Bradette, Heath, Kar, Swagata, Andersen, Hanne, Lewis, Mark G., Cox, Freek, Tolboom, Jeroen T. B. M., de Groot, Anne Marit, Heerwegh, Dirk, Le Gars, Mathieu, Sadoff, Jerald, Wegmann, Frank, Zahn, Roland C., Schuitemaker, Hanneke, Barouch, Dan H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.01.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/590; 631/326/590; Antibodies; Biomedical and Life Sciences; Biomedicine; COVID-19; COVID-19 vaccines; Immunization; Infectious Diseases; Medical Microbiology; Public Health; Rodents; Severe acute respiratory syndrome coronavirus 2; Vaccine; Virology

SARS-CoV-2 Spike-specific binding and neutralizing antibodies, elicited either by natural infection or vaccination, have emerged as potential correlates of protection. An important question, however, is whether vaccine-elicited antibodies in humans provide direct, functional protection from SARS-CoV...