Fig latex inhibits the growth of pathogenic bacteria invading human diabetic wounds and accelerates wound closure in diabetic mice

• Published in: Scientific reports Vol. 12; no. 1; pp. 21852 - 20
• Main Authors: Salah, Mohamed, Badr, Gamal, Hetta, Helal F., Khalifa, Walaa A., Shoreit, Ahmed A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.12.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250; 631/326; 631/443; 631/80; Animals; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics; Antifungal agents; Bacteria; Bacteria - metabolism; beta-Defensins - metabolism; CD31 antigen; Collagen; Collagen - metabolism; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - metabolism; Diabetic Foot - drug therapy; Feet; Ficus - metabolism; Foot diseases; Humanities and Social Sciences; Humans; Latex; Latex - pharmacology; Latex - therapeutic use; Leg ulcers; Mice; Monocyte chemoattractant protein 1; Morbidity; multidisciplinary; Patients; Platelet Endothelial Cell Adhesion Molecule-1; Science; Science (multidisciplinary); Streptozocin; Triterpenoids; Ulcers; Wound healing; Zonula occludens-1 protein

Impaired wound healing is one of the most critical complications associated with diabetes mellitus. Infections and foot ulcers are major causes of morbidity for diabetic patients. The current treatment of diabetic foot ulcers, commonly used antibiotics, is associated with the development of bacteria...