A microsatellite repeat in PCA3 long non-coding RNA is associated with prostate cancer risk and aggressiveness

• Published in: Scientific reports Vol. 7; no. 1; pp. 16862 - 14
• Main Authors: Lai, John, Moya, Leire, An, Jiyuan, Hoffman, Andrea, Srinivasan, Srilakshmi, Panchadsaram, Janaththani, Walpole, Carina, Perry-Keene, Joanna L., Chambers, Suzanne, Lehman, Melanie L., Nelson, Colleen C., Clements, Judith A., Batra, Jyotsna
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.12.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 38/22; 631/67/2322; 631/67/68; Adult; Aged; Aged, 80 and over; Alleles; Androgens; Antigens, Neoplasm - genetics; Base Sequence; Case-Control Studies; Genetic analysis; Genotype; Health risk assessment; Humanities and Social Sciences; Humans; Kaplan-Meier Estimate; Male; Microsatellite Repeats - genetics; Middle Aged; multidisciplinary; Non-coding RNA; Nucleotide sequence; Odds Ratio; Prognosis; Proportional Hazards Models; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - mortality; Prostatic Neoplasms - pathology; Risk Factors; RNA, Long Noncoding - metabolism; Science; Science (multidisciplinary); Short tandem repeats; Tumors

Short tandem repeats (STRs) are repetitive sequences of a polymorphic stretch of two to six nucleotides. We hypothesized that STRs are associated with prostate cancer development and/or progression. We undertook RNA sequencing analysis of prostate tumors and adjacent non-malignant cells to identify...