Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis

• Published in: Nature communications Vol. 13; no. 1; pp. 143 - 12
• Main Authors: Scholz, Markus, Horn, Katrin, Pott, Janne, Gross, Arnd, Kleber, Marcus E., Delgado, Graciela E., Mishra, Pashupati Prasad, Kirsten, Holger, Gieger, Christian, Müller-Nurasyid, Martina, Tönjes, Anke, Kovacs, Peter, Lehtimäki, Terho, Raitakari, Olli, Kähönen, Mika, Gylling, Helena, Baber, Ronny, Isermann, Berend, Stumvoll, Michael, Loeffler, Markus, März, Winfried, Meitinger, Thomas, Peters, Annette, Thiery, Joachim, Teupser, Daniel, Ceglarek, Uta
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.01.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 45/43; 631/208/205/2138; 692/308/2056; 692/4017; 692/699/75; ABO Blood-Group System - blood; ABO Blood-Group System - genetics; Adult; Apolipoprotein E; Apolipoproteins E - blood; Apolipoproteins E - genetics; Arteriosclerosis; Atherosclerosis; ATP Binding Cassette Transporter, Subfamily G, Member 5 - blood; ATP Binding Cassette Transporter, Subfamily G, Member 5 - genetics; ATP Binding Cassette Transporter, Subfamily G, Member 8 - blood; ATP Binding Cassette Transporter, Subfamily G, Member 8 - genetics; Cardiovascular disease; Cholesterol; Cholesterol - blood; Coronary artery; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - genetics; Coronary Artery Disease - pathology; Coronary vessels; Esterification; Female; Gene Expression Regulation; Gene loci; Genetic control; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomes; Heart diseases; Heterogeneity; Homology; Humanities and Social Sciences; Humans; Hydroxymethylglutaryl CoA Reductases - blood; Hydroxymethylglutaryl CoA Reductases - genetics; Lipase - blood; Lipase - genetics; Lipid Metabolism - genetics; Lipoproteins - blood; Lipoproteins - genetics; Male; Membrane Transport Proteins - blood; Membrane Transport Proteins - genetics; Mendelian Randomization Analysis; Meta-analysis; multidisciplinary; Multifactorial Inheritance; Phytosterols; Phytosterols - blood; Polygenic inheritance; Polymorphism, Single Nucleotide; Scavenger Receptors, Class B - blood; Scavenger Receptors, Class B - genetics; Science; Science (multidisciplinary); Single-nucleotide polymorphism; Vein & artery diseases

Phytosterol serum concentrations are under tight genetic control. The relationship between phytosterols and coronary artery disease (CAD) is controversially discussed. We perform a genome-wide meta-analysis of 32 phytosterol traits reflecting resorption, cholesterol synthesis and esterification in s...