Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis - Scholz, Markus; Horn, Katrin; Pott, Janne; Gross, Arnd; Kleber, Marcus E.; Delgado, Graciela E.; Mishra, Pashupati Prasad; Kirsten, Holger; Gieger, Christian; Müller-Nurasyid, Martina; Tönjes, Anke; Kovacs, Peter; et al. (Nature communications, 2022)
Keywords: 45/43; 631/208/205/2138; 692/308/2056; 692/4017; 692/699/75; ABO Blood-Group System - blood; ABO Blood-Group System - genetics; Adult; Apolipoprotein E; Apolipoproteins E - blood; Apolipoproteins E - genetics; Arteriosclerosis; Atherosclerosis; ATP Binding Cassette Transporter, Subfamily G, Member 5 - blood; ATP Binding Cassette Transporter, Subfamily G, Member 5 - genetics; ATP Binding Cassette Transporter, Subfamily G, Member 8 - blood; ATP Binding Cassette Transporter, Subfamily G, Member 8 - genetics; Cardiovascular disease; Cholesterol; Cholesterol - blood; Coronary artery; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - genetics; Coronary Artery Disease - pathology; Coronary vessels; Esterification; Female; Gene Expression Regulation; Gene loci; Genetic control; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomes; Heart diseases; Heterogeneity; Homology; Humanities and Social Sciences; Humans; Hydroxymethylglutaryl CoA Reductases - blood; Hydroxymethylglutaryl CoA Reductases - genetics; Lipase - blood; Lipase - genetics; Lipid Metabolism - genetics; Lipoproteins - blood; Lipoproteins - genetics; Male; Membrane Transport Proteins - blood; Membrane Transport Proteins - genetics; Mendelian Randomization Analysis; Meta-analysis; multidisciplinary; Multifactorial Inheritance; Phytosterols; Phytosterols - blood; Polygenic inheritance; Polymorphism, Single Nucleotide; Scavenger Receptors, Class B - blood; Scavenger Receptors, Class B - genetics; Science; Science (multidisciplinary); Single-nucleotide polymorphism; Vein & artery diseases