STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

• Published in: Nature communications Vol. 10; no. 1; pp. 2830 - 12
• Main Authors: Tegtmeyer, Pia-Katharina, Spanier, Julia, Borst, Katharina, Becker, Jennifer, Riedl, André, Hirche, Christoph, Ghita, Luca, Skerra, Jennifer, Baumann, Kira, Lienenklaus, Stefan, Doering, Marius, Ruzsics, Zsolt, Kalinke, Ulrich
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.06.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13/21; 59/5; 631/250/254; 631/250/262/2106; 64/60; 692/420; Animals; Coding; Cytomegalovirus; Female; Hepatocytes; Hepatocytes - metabolism; Hepatocytes - virology; Herpesviridae Infections - veterinary; Herpesviridae Infections - virology; Host-Pathogen Interactions; Humanities and Social Sciences; Infections; Interferon; Interferon-beta - genetics; Interferon-beta - metabolism; Kupffer cells; Kupffer Cells - metabolism; Kupffer Cells - virology; Liver - metabolism; Liver - virology; Macrophages; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; multidisciplinary; Muromegalovirus - genetics; Muromegalovirus - physiology; Myeloid cells; Myeloid Cells - metabolism; Myeloid Cells - virology; Organs; Rodent Diseases - genetics; Rodent Diseases - metabolism; Rodent Diseases - virology; Science; Science (multidisciplinary); Signal Transduction; Survival; Toll-like receptors; Toll-Like Receptors - genetics; Toll-Like Receptors - metabolism; Viruses; β-Interferon

Cytomegalovirus is a DNA-encoded β-herpesvirus that induces STING-dependent type 1 interferon responses in macrophages and uses myeloid cells as a vehicle for dissemination. Here we report that STING knockout mice are as resistant to murine cytomegalovirus (MCMV) infection as wild-type controls, whe...