Gene expression dataset for whole cochlea of Macaca fascicularis

Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. To better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in M. fas...

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Published inScientific reports Vol. 8; no. 1; pp. 15554 - 9
Main Authors Mutai, Hideki, Miya, Fuyuki, Shibata, Hiroaki, Yasutomi, Yasuhiro, Tsunoda, Tatsuhiko, Matsunaga, Tatsuo
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 22.10.2018
Nature Publishing Group
Subjects
38/61
631/208/199
631/378/1959
Animal models
Auditory system
Cochlea
DNA microarrays
Ear
Gene expression
Gene set enrichment analysis
Hearing loss
Humanities and Social Sciences
Macaca fascicularis
Morphogenesis
multidisciplinary
Science
Science (multidisciplinary)
Cochlear Tissue
Bilateral Cochlea
Human Array
Tsukuba Primate Research Center (TPRC)
Autosomal Dominant Non-syndromic Deafness
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Abstract Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. To better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in M. fascicularis cochlea. We compared the cochlear transcripts obtained from an adult male M. fascicularis by macaque and human GeneChip microarrays with those in multiple macaque and human tissues or cells and identified 344 genes with expression levels more than 2-fold greater than in the other tissues. These “cochlear signature genes” included 35 genes responsible for syndromic or nonsyndromic hereditary hearing loss. Gene set enrichment analysis revealed groups of genes categorized as “ear development” and “ear morphogenesis” in the top 20 gene ontology categories in the macaque and human arrays, respectively. This dataset will facilitate both the study of genes that contribute to primate cochlear function and provide insight to discover novel genes associated with hereditary hearing loss that have yet to be established using animal models.
AbstractList Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. To better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in M. fascicularis cochlea. We compared the cochlear transcripts obtained from an adult male M. fascicularis by macaque and human GeneChip microarrays with those in multiple macaque and human tissues or cells and identified 344 genes with expression levels more than 2-fold greater than in the other tissues. These “cochlear signature genes” included 35 genes responsible for syndromic or nonsyndromic hereditary hearing loss. Gene set enrichment analysis revealed groups of genes categorized as “ear development” and “ear morphogenesis” in the top 20 gene ontology categories in the macaque and human arrays, respectively. This dataset will facilitate both the study of genes that contribute to primate cochlear function and provide insight to discover novel genes associated with hereditary hearing loss that have yet to be established using animal models.
Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. To better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in M. fascicularis cochlea. We compared the cochlear transcripts obtained from an adult male M. fascicularis by macaque and human GeneChip microarrays with those in multiple macaque and human tissues or cells and identified 344 genes with expression levels more than 2-fold greater than in the other tissues. These "cochlear signature genes" included 35 genes responsible for syndromic or nonsyndromic hereditary hearing loss. Gene set enrichment analysis revealed groups of genes categorized as "ear development" and "ear morphogenesis" in the top 20 gene ontology categories in the macaque and human arrays, respectively. This dataset will facilitate both the study of genes that contribute to primate cochlear function and provide insight to discover novel genes associated with hereditary hearing loss that have yet to be established using animal models.
ArticleNumber 15554
Author Miya, Fuyuki
Yasutomi, Yasuhiro
Tsunoda, Tatsuhiko
Matsunaga, Tatsuo
Mutai, Hideki
Shibata, Hiroaki
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  surname: Matsunaga
  fullname: Matsunaga, Tatsuo
  organization: Division Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Medical Genetics Center, National Hospital Organization Tokyo Medical Center
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Issue 1
Keywords Cochlear Tissue
Bilateral Cochlea
Human Array
Tsukuba Primate Research Center (TPRC)
Autosomal Dominant Non-syndromic Deafness
Language English
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Snippet Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of...
Macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of...
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SubjectTerms 38/61
631/208/199
631/378/1959
Animal models
Auditory system
Cochlea
DNA microarrays
Ear
Gene expression
Gene set enrichment analysis
Hearing loss
Humanities and Social Sciences
Macaca fascicularis
Morphogenesis
multidisciplinary
Science
Science (multidisciplinary)
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Title Gene expression dataset for whole cochlea of Macaca fascicularis
URI https://link.springer.com/article/10.1038/s41598-018-33985-9
https://www.ncbi.nlm.nih.gov/pubmed/30349143
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https://pubmed.ncbi.nlm.nih.gov/PMC6197234
Volume 8
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