Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis

• Published in: Scientific reports Vol. 7; no. 1; pp. 17225 - 11
• Main Authors: Asano, Keiichi, Nelson, Courtney M., Nandadasa, Sumeda, Aramaki-Hattori, Noriko, Lindner, Daniel J., Alban, Tyler, Inagaki, Junko, Ohtsuki, Takashi, Oohashi, Toshitaka, Apte, Suneel S., Hirohata, Satoshi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.12.2017; Nature Publishing Group
• Subjects: 13/51; 14/19; 38/77; 631/67/2328; 631/67/327; 64/60; 82/29; 82/80; Angiogenesis; Animals; Capillaries; Cell Line, Tumor; Cell Proliferation; Endothelium; Gene Expression Regulation, Neoplastic; Humanities and Social Sciences; Lung cancer; Lung carcinoma; Macrophages; Macrophages - metabolism; Metastases; Mice; multidisciplinary; Neoplasm Metastasis; Neovascularization, Pathologic - metabolism; Proteolysis; Science; Science (multidisciplinary); Stroma; Stromal Cells - metabolism; Tumor cell lines; Tumor Microenvironment; Tumors; Versican; Versicans - biosynthesis; Versicans - genetics; Versicans - metabolism

The proteoglycan versican is implicated in growth and metastases of several cancers. Here we investigated a potential contribution of stromal versican to tumor growth and angiogenesis. We initially determined versican expression by several cancer cell lines. Among these, MDA-MB231 and B16F10 had non...