Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability - Gao, Zhengjun; Li, Yiyuan; Wang, Fei; Huang, Tao; Fan, Keqi; Zhang, Yu; Zhong, Jiangyan; Cao, Qian; Chao, Tong; Jia, Junling; Yang, Shuo; Zhang, Long; et al. (Nature communications, 2017)
Keywords: 631/250/256/2516; 631/250/262; 631/250/580; 631/80/642/333; Animals; Cancer; Cancer immunotherapy; Cell activation; Control stability; Cytology; Dendritic cells; Dynamic stability; Female; Fission; Humanities and Social Sciences; Humans; Immune response; Immune system; Immunity; Immunity, Innate; Immunotherapy; Inflammation; Innate immunity; Interferon regulatory factor 1; Interferon Regulatory Factor-1 - genetics; Interferon Regulatory Factor-1 - metabolism; Interleukin 12; Interleukin-12 - metabolism; Lymphocyte Activation - immunology; Lymphocytes T; Macrophages; Macrophages - immunology; Macrophages - metabolism; Male; Membrane proteins; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondria - metabolism; Mitochondrial DNA; Mitochondrial Dynamics - immunology; Mitochondrial Proteins - metabolism; Morphology; multidisciplinary; Neoplasms - immunology; Parkin protein; Proteins; Proteolysis; Recruitment; Science; Science (multidisciplinary); Signal Transduction - immunology; Switching; T cell receptors; T-Lymphocytes - immunology; Toll-like receptors; Toll-Like Receptors - immunology; Toll-Like Receptors - metabolism; Tumors; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Xenograft Model Antitumor Assays