Modeling material transport regulation and traffic jam in neurons using PDE-constrained optimization

• Published in: Scientific reports Vol. 12; no. 1; pp. 3902 - 13
• Main Authors: Li, Angran, Zhang, Yongjie Jessica
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.03.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/116; 639/705/1041; 639/766/747; Axonal transport; Biological Transport; Computer Simulation; Humanities and Social Sciences; Humans; Immunoglobulin A; Intracellular; Microtubules; Microtubules - metabolism; Models, Molecular; multidisciplinary; Neurodegenerative diseases; Neurons; Objective function; Optimization; Partial differential equations; Science; Science (multidisciplinary); Traffic congestion; Transport processes
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-07861-6

The intracellular transport process plays an important role in delivering essential materials throughout branched geometries of neurons for their survival and function. Many neurodegenerative diseases have been associated with the disruption of transport. Therefore, it is essential to study how neur...