Mucosal microvilli in dry eye patients with chronic GVHD

• Published in: Bone marrow transplantation (Basingstoke) Vol. 47; no. 3; pp. 416 - 425
• Main Authors: Tatematsu, Y, Ogawa, Y, Shimmura, S, Dogru, M, Yaguchi, S, Nagai, T, Yamazaki, K, Kameyama, K, Okamoto, S, Kawakami, Y, Tsubota, K
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2012; Nature Publishing Group
• Subjects: Adult; Anatomy; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bone marrow; Bone marrow, stem cells transplantation. Graft versus host reaction; CD8 antigen; CD8-Positive T-Lymphocytes - cytology; Cell Biology; Conjunctiva; Conjunctiva - immunology; Cytology; Development and progression; Dry Eye Syndromes; Electron micrographs; Eye; Female; Glycocalyx; Glycocalyx - metabolism; Goblet cells; Graft versus host reaction; Graft vs Host Disease - immunology; Hematology; Humans; Immunohistochemistry; Immunohistochemistry - methods; Internal Medicine; Light microscopy; Lymphocytes; Lymphocytes T; Male; Medical sciences; Medicine; Medicine & Public Health; Metaplasia; Micrography; Microscopy - methods; Microvilli - metabolism; Middle Aged; Mucin; Mucosa; Mucous membrane; Mucous Membrane - metabolism; Optical microscopy; original-article; Public Health; Secretory vesicles; Sjogren's syndrome; Sjogren's Syndrome - immunology; Stem cell transplantation; Stem Cells; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Vesicles; microvilli; secretory vesicle; chronic GVHD; ocular surface glycocalyx; dry eye; mucosal membrane; Human; Vesicle; Immunopathology; Graft versus host disease; Hematology; Stem cell; Mucosa; Hematopoietic cell; Microvilli; Eye; Visual system; Dry eye syndrome; Eye disease; Chronic; Dry eye

The ocular surface is a frequent target tissue of mucosal chronic GVHD (cGVHD). We investigated the histopathological features of the conjunctival microvilli in patients with cGVHD. Conjunctival tissue specimens from patients with cGVHD or Sjögren's syndrome (SS) or from healthy individuals wer...