Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis

• Published in: Nature communications Vol. 13; no. 1; pp. 1371 - 16
• Main Authors: Wu, Mingming, Zhang, Xiao, Zhang, Weijie, Chiou, Yi Shiou, Qian, Wenchang, Liu, Xiangtian, Zhang, Min, Yan, Hong, Li, Shilan, Li, Tao, Han, Xinghua, Qian, Pengxu, Liu, Suling, Pan, Yueyin, Lobie, Peter E., Zhu, Tao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.03.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/100; 13/109; 13/21; 13/31; 13/51; 13/89; 13/95; 14; 14/19; 14/5; 38; 38/15; 38/61; 42; 45; 59; 631/67/1059; 631/67/1347; 631/67/2329; 631/67/322; 631/67/71; 64; 64/60; 96; Adaptation, Physiological; Breast cancer; Breast Neoplasms - pathology; Cell Line, Tumor; Combined treatment; Dkk1 protein; Female; Ferroptosis; Homeostasis; Humanities and Social Sciences; Humans; Inhibitors; Lipid Peroxidation; Lipids; Metastases; Metastasis; multidisciplinary; Neoplastic Stem Cells - metabolism; Peroxidation; Phenotypic plasticity; Plastic properties; Plasticity; Science; Science (multidisciplinary); Secretome; Stem cells; Synergistic effect; Tumors

Cancer cells display phenotypic equilibrium between the stem-like and differentiated states during neoplastic homeostasis. The functional and mechanistic implications of this subpopulation plasticity remain largely unknown. Herein, it is demonstrated that the breast cancer stem cell (BCSC) secretome...