A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or “wet” form of AMD, no therapy is successful for the non-neovascular or “dry” form. Here we discuss the current knowledge on dry A...

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Published inNature communications Vol. 10; no. 1; pp. 3347 - 11
Main Authors Handa, James T., Bowes Rickman, Cathy, Dick, Andrew D., Gorin, Michael B., Miller, Joan W., Toth, Cynthia A., Ueffing, Marius, Zarbin, Marco, Farrer, Lindsay A.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.07.2019
Nature Publishing Group
Nature Portfolio
Subjects
631/553
692/53
692/698/1688/512/2613
692/699/3161/1626
Age
Age related diseases
Animals
Biomarkers
Blindness
Geriatrics
Humanities and Social Sciences
Humans
Macular degeneration
Macular Degeneration - immunology
Macular Degeneration - metabolism
Macular Degeneration - pathology
Macular Degeneration - therapy
Mathematical models
multidisciplinary
Oxidative Stress
Perspective
Pharmacology
Science
Science (multidisciplinary)
Systems Biology
Therapy
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Abstract Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or “wet” form of AMD, no therapy is successful for the non-neovascular or “dry” form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy. No effective therapies exist for dry age-related macular degeneration. In this perspective, the authors propose that research should emphasize system biology approaches that integrate various ‘omics’ data into mathematical models to establish pathogenic mechanisms on which to design novel treatments, and identify biomarkers that predict disease progression and therapeutic response.
AbstractList Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or “wet” form of AMD, no therapy is successful for the non-neovascular or “dry” form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy. No effective therapies exist for dry age-related macular degeneration. In this perspective, the authors propose that research should emphasize system biology approaches that integrate various ‘omics’ data into mathematical models to establish pathogenic mechanisms on which to design novel treatments, and identify biomarkers that predict disease progression and therapeutic response.
Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or “wet” form of AMD, no therapy is successful for the non-neovascular or “dry” form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy.
No effective therapies exist for dry age-related macular degeneration. In this perspective, the authors propose that research should emphasize system biology approaches that integrate various ‘omics’ data into mathematical models to establish pathogenic mechanisms on which to design novel treatments, and identify biomarkers that predict disease progression and therapeutic response.
ArticleNumber 3347
Author Handa, James T.
Bowes Rickman, Cathy
Zarbin, Marco
Toth, Cynthia A.
Ueffing, Marius
Gorin, Michael B.
Dick, Andrew D.
Miller, Joan W.
Farrer, Lindsay A.
Author_xml – sequence: 1
  givenname: James T.
  surname: Handa
  fullname: Handa, James T.
  email: jthanda@jhmi.edu
  organization: Wilmer Eye Institute, Johns Hopkins University
– sequence: 2
  givenname: Cathy
  surname: Bowes Rickman
  fullname: Bowes Rickman, Cathy
  organization: Department of Ophthalmology, Duke University Medical Center
– sequence: 3
  givenname: Andrew D.
  surname: Dick
  fullname: Dick, Andrew D.
  organization: Translational Health Sciences (Ophthalmology), University of Bristol, University College London, Institute of Ophthalmology and the National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital and UCL-Institute of Ophthalmology
– sequence: 4
  givenname: Michael B.
  orcidid: 0000-0001-9498-7982
  surname: Gorin
  fullname: Gorin, Michael B.
  organization: Department of Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine, UCLA, Brain Research Institute, UCLA
– sequence: 5
  givenname: Joan W.
  orcidid: 0000-0003-2046-3996
  surname: Miller
  fullname: Miller, Joan W.
  organization: Retina Service, Massachusetts Eye and Ear, Harvard Ophthalmology AMD Center of Excellence, Department of Ophthalmology, Harvard Medical School
– sequence: 6
  givenname: Cynthia A.
  surname: Toth
  fullname: Toth, Cynthia A.
  organization: Department of Ophthalmology, Duke University Medical Center
– sequence: 7
  givenname: Marius
  surname: Ueffing
  fullname: Ueffing, Marius
  organization: Department of Ophthalmology, Institute for Ophthalmic Research, University of Tübingen
– sequence: 8
  givenname: Marco
  surname: Zarbin
  fullname: Zarbin, Marco
  organization: Institute of Ophthalmology and Visual Science, New Jersey Medical School, Rutgers University
– sequence: 9
  givenname: Lindsay A.
  surname: Farrer
  fullname: Farrer, Lindsay A.
  email: farrer@bu.edu
  organization: Departments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31350409$$D View this record in MEDLINE/PubMed
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SecondaryResourceType review_article
Snippet Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the...
No effective therapies exist for dry age-related macular degeneration. In this perspective, the authors propose that research should emphasize system biology...
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StartPage 3347
SubjectTerms 631/553
692/53
692/698/1688/512/2613
692/699/3161/1626
Age
Age related diseases
Animals
Biomarkers
Blindness
Geriatrics
Humanities and Social Sciences
Humans
Macular degeneration
Macular Degeneration - immunology
Macular Degeneration - metabolism
Macular Degeneration - pathology
Macular Degeneration - therapy
Mathematical models
multidisciplinary
Oxidative Stress
Perspective
Pharmacology
Science
Science (multidisciplinary)
Systems Biology
Therapy
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Title A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
URI https://link.springer.com/article/10.1038/s41467-019-11262-1
https://www.ncbi.nlm.nih.gov/pubmed/31350409
https://www.proquest.com/docview/2264592007
https://search.proquest.com/docview/2265793190
https://pubmed.ncbi.nlm.nih.gov/PMC6659646
https://doaj.org/article/3214b0dbb9844fa984ecd1315c89c90d
Volume 10
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