Unveiling genetic variants for age-related sarcopenia by conducting a genome-wide association study on Korean cohorts

• Published in: Scientific reports Vol. 12; no. 1; pp. 3501 - 12
• Main Authors: Jin, Heejin, Yoo, Hyun Ju, Kim, Ye An, Lee, Ji Hyun, Lee, Young, Kwon, Seung-hyun, Seo, Young Joo, Lee, Seung Hun, Koh, Jung-Min, Ji, Yunmi, Do, Ah Ra, Won, Sungho, Seo, Je Hyun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.03.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208/205; 692/308/2056; 692/698/1671/1668/1973; 692/700/1518; Age; Aged; Biomarkers; Body mass; Energy metabolism; Gene expression; Gene mapping; Genetic analysis; Genetic diversity; Genetic Markers; Genetic variance; Genome-wide association studies; Genome-Wide Association Study; Genomes; Humanities and Social Sciences; Humans; Lean body mass; Lipid metabolism; multidisciplinary; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Musculoskeletal system; Quantitative trait loci; Republic of Korea - epidemiology; Ribosomal Proteins - metabolism; Sarcopenia; Science; Science (multidisciplinary); Single-nucleotide polymorphism; Skeletal muscle; Republic of Korea

Sarcopenia is an age-related disorder characterised by a progressive decrease in skeletal muscle mass. As the genetic biomarkers for sarcopenia are not yet well characterised, this study aimed to investigate the genetic variations related to sarcopenia in a relatively aged cohort, using genome-wide...