Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging

Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 9; no. 1; pp. 644 - 11
Main Authors Oh, Gabriel, Ebrahimi, Sasha, Carlucci, Matthew, Zhang, Aiping, Nair, Akhil, Groot, Daniel E., Labrie, Viviane, Jia, Peixin, Oh, Edward S., Jeremian, Richie H., Susic, Miki, Shrestha, Tenjin C., Ralph, Martin R., Gordevičius, Juozas, Koncevičius, Karolis, Petronis, Art
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.02.2018
Nature Publishing Group
Nature Portfolio
Subjects
38/22
38/77
38/88
38/90
42/47
49/23
631/136/7
631/337/176/1988
631/80/105
64/60
Aging
Biodiversity
Circadian rhythm
Circadian rhythms
Cytosine
Epigenetics
Humanities and Social Sciences
Machinery and equipment
multidisciplinary
Oscillations
Proteomics
Science
Science (multidisciplinary)
Online AccessGet full text

Cover

Abstract Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism’s deterioration. While epigenetic factors have been implicated in the circadian rhythm, the detection of circadian cytosine modifications has remained elusive. Here the authors identify a large number of epigenetically variable cytosines that show circadian oscillations in their modification status in mice.
AbstractList Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism's deterioration.Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism's deterioration.
Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism’s deterioration. While epigenetic factors have been implicated in the circadian rhythm, the detection of circadian cytosine modifications has remained elusive. Here the authors identify a large number of epigenetically variable cytosines that show circadian oscillations in their modification status in mice.
While epigenetic factors have been implicated in the circadian rhythm, the detection of circadian cytosine modifications has remained elusive. Here the authors identify a large number of epigenetically variable cytosines that show circadian oscillations in their modification status in mice.
Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism’s deterioration.
ArticleNumber 644
Author Petronis, Art
Zhang, Aiping
Ebrahimi, Sasha
Labrie, Viviane
Koncevičius, Karolis
Carlucci, Matthew
Susic, Miki
Gordevičius, Juozas
Oh, Edward S.
Oh, Gabriel
Groot, Daniel E.
Jia, Peixin
Jeremian, Richie H.
Ralph, Martin R.
Nair, Akhil
Shrestha, Tenjin C.
Author_xml – sequence: 1
  givenname: Gabriel
  surname: Oh
  fullname: Oh, Gabriel
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
– sequence: 2
  givenname: Sasha
  surname: Ebrahimi
  fullname: Ebrahimi, Sasha
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
– sequence: 3
  givenname: Matthew
  surname: Carlucci
  fullname: Carlucci, Matthew
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
– sequence: 4
  givenname: Aiping
  surname: Zhang
  fullname: Zhang, Aiping
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
– sequence: 5
  givenname: Akhil
  surname: Nair
  fullname: Nair, Akhil
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
– sequence: 6
  givenname: Daniel E.
  surname: Groot
  fullname: Groot, Daniel E.
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
– sequence: 7
  givenname: Viviane
  surname: Labrie
  fullname: Labrie, Viviane
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Center for Neurodegenerative Science, Van Andel Research Institute
– sequence: 8
  givenname: Peixin
  surname: Jia
  fullname: Jia, Peixin
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
– sequence: 9
  givenname: Edward S.
  surname: Oh
  fullname: Oh, Edward S.
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
– sequence: 10
  givenname: Richie H.
  surname: Jeremian
  fullname: Jeremian, Richie H.
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
– sequence: 11
  givenname: Miki
  surname: Susic
  fullname: Susic, Miki
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
– sequence: 12
  givenname: Tenjin C.
  surname: Shrestha
  fullname: Shrestha, Tenjin C.
  organization: Department of Cell and Systems Biology, University of Toronto, Department of Psychology, University of Toronto
– sequence: 13
  givenname: Martin R.
  surname: Ralph
  fullname: Ralph, Martin R.
  organization: Department of Psychology, University of Toronto
– sequence: 14
  givenname: Juozas
  surname: Gordevičius
  fullname: Gordevičius, Juozas
  organization: Institute of Biotechnology, Life Sciences Center, Vilnius University, Institute of Data Science and Digital Technologies, Vilnius University
– sequence: 15
  givenname: Karolis
  surname: Koncevičius
  fullname: Koncevičius, Karolis
  organization: Institute of Biotechnology, Life Sciences Center, Vilnius University, Institute of Data Science and Digital Technologies, Vilnius University
– sequence: 16
  givenname: Art
  surname: Petronis
  fullname: Petronis, Art
  email: Art.Petronis@camh.ca
  organization: The Krembil Family Epigenetics Laboratory, The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Institute of Biotechnology, Life Sciences Center, Vilnius University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29440637$$D View this record in MEDLINE/PubMed
BookMark eNp9kk1v1DAQhiNURD_oH-CAInHhEvBHnDgXJLSCUqkSFzhbjjPOziprL7Z31f33eDdbaHuoL7Y87_vo1cxcFmfOOyiKd5R8ooTLz7GmddNWhMqKcNLyqn1VXDBS04q2jJ89ep8X1zGuSD68o7Ku3xTnrKtr0vD2osDFPvmIDsq1H9Ci0Qm9iyXcL7HHVBoMRg-oXemjwWk6ldNSp1IHKNHt_LSDIT9K2OAIDhKacsAdhIhpX2o3lHpEN74tXls9Rbg-3VfF7-_ffi1-VHc_b24XX-8qI2qSKq65tYIN0DeyoT1rJQjDmKYARHBpGttbMGA10xKsoFYMWlBmQUNnqeD8qriduYPXK7UJuNZhr7xGdfzwYVQ65IwTKNnZjkieXcbWjWg7KgCYbuvGdtA1IrO-zKzNtl_DYMCloKcn0KcVh0s1-p0SklLRthnw8QQI_s8WYlJrjAZyHx34bVSMEMZoQynL0g_PpCu_DS636qCisuvynLPq_eNE_6I8TDQL5CwwwccYwCqD6Ti1HBAnRYk67I-a90dlsDrujzpY2TPrA_1FE59NMYvdCOF_7BdcfwHfGNmo
CitedBy_id crossref_primary_10_3389_fgene_2019_01058
crossref_primary_10_59368_agingbio_20240031
crossref_primary_10_1002_jcsm_12556
crossref_primary_10_1103_PhysRevE_105_034411
crossref_primary_10_1128_spectrum_05323_22
crossref_primary_10_7554_eLife_47333
crossref_primary_10_1038_s41398_020_01186_6
crossref_primary_10_7554_eLife_54186
crossref_primary_10_1016_j_schres_2021_05_010
crossref_primary_10_3390_epigenomes6040033
crossref_primary_10_1093_gerona_glab047
crossref_primary_10_3389_fgene_2020_00224
crossref_primary_10_1038_s41598_021_94281_7
crossref_primary_10_1016_j_freeradbiomed_2021_01_009
crossref_primary_10_1016_j_arr_2021_101424
crossref_primary_10_1016_j_pbiomolbio_2025_01_003
crossref_primary_10_1016_j_molcel_2018_08_008
crossref_primary_10_1038_s41576_024_00807_w
crossref_primary_10_1016_j_arr_2024_102232
crossref_primary_10_1186_s13059_018_1608_9
crossref_primary_10_3389_fevo_2019_00152
crossref_primary_10_3389_fphys_2022_911437
crossref_primary_10_1177_0748730418779958
crossref_primary_10_1038_s41576_022_00477_6
crossref_primary_10_1080_00325481_2019_1681215
crossref_primary_10_1111_jsr_14438
crossref_primary_10_1134_S0006297922010047
crossref_primary_10_1186_s13148_019_0677_2
crossref_primary_10_1021_acs_est_2c02961
crossref_primary_10_3389_fendo_2021_681356
crossref_primary_10_31857_S0320972522010092
crossref_primary_10_1016_j_tig_2018_09_005
crossref_primary_10_3390_biology11071071
crossref_primary_10_1080_15592294_2019_1626651
crossref_primary_10_1186_s13073_019_0704_0
crossref_primary_10_1016_j_lfs_2019_02_006
crossref_primary_10_1038_s41576_021_00348_6
crossref_primary_10_1038_s41467_023_40816_7
crossref_primary_10_1186_s13059_019_1824_y
crossref_primary_10_1038_s41566_023_01265_2
crossref_primary_10_1038_s41576_018_0004_3
crossref_primary_10_1177_07487304221083507
crossref_primary_10_1016_j_jad_2020_01_040
Cites_doi 10.1073/pnas.1408886111
10.1093/hmg/ddt375
10.1126/science.1170116
10.1186/s13059-016-1030-0
10.1016/j.cmet.2012.11.004
10.18632/aging.101005
10.1126/science.aah4965
10.1038/nrg1633
10.1038/nrn3208
10.1126/science.1220671
10.1038/ncomms7363
10.18632/aging.101020
10.1038/nbt.1630
10.1152/physiolgenomics.00060.2007
10.1038/nri3386
10.1016/j.cell.2013.11.034
10.1093/bioinformatics/btu170
10.1038/nature00965
10.1038/nsmb.1961
10.1126/science.1196766
10.1073/pnas.0400782101
10.1093/nar/gkp335
10.1371/journal.pone.0118101
10.1038/nrg2430
10.1371/journal.pone.0021800
10.1038/nn.3651
10.1038/sj.emboj.7600509
10.1101/gad.10.4.447
10.1038/ncb2879
10.1371/journal.pgen.1004792
10.1038/ncomms5753
10.1016/j.cell.2013.05.039
10.1038/nmeth.1923
10.1101/gad.1067003
10.1186/s13059-016-0946-8
10.1038/nmeth.1871
10.1093/nar/gks1161
10.1126/science.1226339
10.1016/j.celrep.2014.09.048
10.1186/gb-2013-14-10-r115
10.1038/ng1738
ContentType Journal Article
Copyright The Author(s) 2018
2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2018
– notice: 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-018-03073-7
DatabaseName Springer Nature OA Free Journals (WRLC)
CrossRef
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials - QC
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic



CrossRef
Publicly Available Content Database
PubMed
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 11
ExternalDocumentID oai_doaj_org_article_89f9083153cf4657915ee2a746f9e965
PMC5811577
29440637
10_1038_s41467_018_03073_7
Genre Journal Article
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BAPOH
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
NPM
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
RC3
SOI
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c540t-3a3ff52deb6861b278e5c22a1ee0538c6fbfecefa2a8ef51f5da512feae9f1533
IEDL.DBID M48
ISSN 2041-1723
IngestDate Wed Aug 27 01:22:33 EDT 2025
Thu Aug 21 18:24:04 EDT 2025
Fri Jul 11 09:42:27 EDT 2025
Wed Aug 13 05:10:44 EDT 2025
Mon Jul 21 06:03:54 EDT 2025
Thu Apr 24 22:58:47 EDT 2025
Tue Jul 01 02:21:10 EDT 2025
Fri Feb 21 02:39:52 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-3a3ff52deb6861b278e5c22a1ee0538c6fbfecefa2a8ef51f5da512feae9f1533
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://doaj.org/article/89f9083153cf4657915ee2a746f9e965
PMID 29440637
PQID 2001899030
PQPubID 546298
PageCount 11
ParticipantIDs doaj_primary_oai_doaj_org_article_89f9083153cf4657915ee2a746f9e965
pubmedcentral_primary_oai_pubmedcentral_nih_gov_5811577
proquest_miscellaneous_2002216112
proquest_journals_2001899030
pubmed_primary_29440637
crossref_citationtrail_10_1038_s41467_018_03073_7
crossref_primary_10_1038_s41467_018_03073_7
springer_journals_10_1038_s41467_018_03073_7
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2018-02-13
PublicationDateYYYYMMDD 2018-02-13
PublicationDate_xml – month: 02
  year: 2018
  text: 2018-02-13
  day: 13
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2018
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Froy (CR4) 2011; 26
Elliott (CR28) 2015; 6
Zhang, Lahens, Ballance, Hughes, Hogenesch (CR7) 2014; 111
Krueger, Andrews (CR38) 2011
Katada, Sassone-Corsi (CR10) 2010; 17
Takahashi, Hong, Ko, McDearmon (CR2) 2008; 9
Lim (CR15) 2014; 10
Bell-Pedersen (CR1) 2005; 6
Diep (CR16) 2012; 9
Supek, Bosnjak, Skunca, Smuc (CR44) 2011; 6
Su (CR40) 2004; 101
Scheiermann, Kunisaki, Frenette (CR20) 2013; 13
Desbarats, Gaubatz, Eilers (CR22) 1996; 10
Chen (CR32) 2016; 8
Duong, Robles, Knutti, Weitz (CR9) 2011; 332
McLean (CR43) 2010; 28
Hill (CR30) 1965; 58
Oh (CR25) 2016; 17
Eckel-Mahan (CR8) 2013; 155
Tahiliani (CR17) 2009; 324
Vollmers (CR14) 2012; 16
Azzi (CR13) 2014; 17
Horvath (CR34) 2016; 8
Bolger, Lohse, Usadel (CR37) 2014; 30
Brenner (CR23) 2005; 24
Bochkis, Przybylski, Chen, Regev (CR26) 2014; 9
Bailey (CR45) 2009; 37
Kondratova, Kondratov (CR3) 2012; 13
Booth (CR18) 2012; 336
Pizarro, Hayer, Lahens, Hogenesch (CR41) 2013; 41
Fernandez (CR21) 2003; 17
CR42
Haspel (CR19) 2014; 5
Horvath (CR33) 2016; 17
Lopez-Otin, Blasco, Partridge, Serrano, Kroemer (CR29) 2013; 153
Langmead, Salzberg (CR39) 2012; 9
Koike (CR11) 2012; 338
Xia (CR12) 2015; 10
Reppert, Weaver (CR6) 2002; 418
Bass, Lazar (CR36) 2016; 354
Ripperger, Schibler (CR5) 2006; 38
Teschendorff, West, Beck (CR24) 2013; 22
Misra (CR27) 2007; 31
Cruickshanks (CR35) 2013; 15
Horvath (CR31) 2013; 14
AS Lim (3073_CR15) 2014; 10
N Koike (3073_CR11) 2012; 338
3073_CR42
C Scheiermann (3073_CR20) 2013; 13
AM Bolger (3073_CR37) 2014; 30
A Pizarro (3073_CR41) 2013; 41
A Azzi (3073_CR13) 2014; 17
J Bass (3073_CR36) 2016; 354
MJ Booth (3073_CR18) 2012; 336
PC Fernandez (3073_CR21) 2003; 17
F Krueger (3073_CR38) 2011
BH Chen (3073_CR32) 2016; 8
AE Teschendorff (3073_CR24) 2013; 22
D Bell-Pedersen (3073_CR1) 2005; 6
L Desbarats (3073_CR22) 1996; 10
V Misra (3073_CR27) 2007; 31
M Tahiliani (3073_CR17) 2009; 324
AA Kondratova (3073_CR3) 2012; 13
HA Duong (3073_CR9) 2011; 332
L Xia (3073_CR12) 2015; 10
O Froy (3073_CR4) 2011; 26
R Zhang (3073_CR7) 2014; 111
CY McLean (3073_CR43) 2010; 28
F Supek (3073_CR44) 2011; 6
AI Su (3073_CR40) 2004; 101
G Elliott (3073_CR28) 2015; 6
JA Ripperger (3073_CR5) 2006; 38
C Brenner (3073_CR23) 2005; 24
JA Haspel (3073_CR19) 2014; 5
C Vollmers (3073_CR14) 2012; 16
TL Bailey (3073_CR45) 2009; 37
S Horvath (3073_CR34) 2016; 8
HA Cruickshanks (3073_CR35) 2013; 15
B Langmead (3073_CR39) 2012; 9
S Katada (3073_CR10) 2010; 17
S Horvath (3073_CR33) 2016; 17
IM Bochkis (3073_CR26) 2014; 9
KL Eckel-Mahan (3073_CR8) 2013; 155
JS Takahashi (3073_CR2) 2008; 9
D Diep (3073_CR16) 2012; 9
C Lopez-Otin (3073_CR29) 2013; 153
AB Hill (3073_CR30) 1965; 58
SM Reppert (3073_CR6) 2002; 418
G Oh (3073_CR25) 2016; 17
S Horvath (3073_CR31) 2013; 14
19372391 - Science. 2009 May 15;324(5929):930-5
24531307 - Nat Neurosci. 2014 Mar;17(3):377-82
23746838 - Cell. 2013 Jun 6;153(6):1194-217
22539555 - Science. 2012 May 18;336(6083):934-7
21113167 - Nat Struct Mol Biol. 2010 Dec;17(12):1414-21
19458158 - Nucleic Acids Res. 2009 Jul;37(Web Server issue):W202-8
14283879 - Proc R Soc Med. 1965 May;58:295-300
22395806 - Nat Rev Neurosci. 2012 Mar 07;13(5):325-35
25208554 - Nat Commun. 2014 Sep 11;5:4753
27885004 - Science. 2016 Nov 25;354(6315):994-999
25349387 - Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16219-24
22936566 - Science. 2012 Oct 19;338(6105):349-54
27122015 - Genome Biol. 2016 Apr 28;17 :76
15616584 - EMBO J. 2005 Jan 26;24(2):336-46
27511193 - Genome Biol. 2016 Aug 11;17 (1):171
24138928 - Genome Biol. 2013;14(10):R115
21789182 - PLoS One. 2011;6(7):e21800
23180795 - Nucleic Acids Res. 2013 Jan;41(Database issue):D1009-13
12198538 - Nature. 2002 Aug 29;418(6901):935-41
21493656 - Bioinformatics. 2011 Jun 1;27(11):1571-2
24360271 - Cell. 2013 Dec 19;155(7):1464-78
21841071 - Physiology (Bethesda). 2011 Aug;26(4):225-35
21680841 - Science. 2011 Jun 17;332(6036):1436-9
16474407 - Nat Genet. 2006 Mar;38(3):369-74
25689298 - PLoS One. 2015 Feb 17;10(2):e0118101
12695333 - Genes Dev. 2003 May 1;17(9):1115-29
23918660 - Hum Mol Genet. 2013 Oct 15;22(R1):R7-R15
18802415 - Nat Rev Genet. 2008 Oct;9(10):764-75
8600028 - Genes Dev. 1996 Feb 15;10(4):447-60
22306810 - Nat Methods. 2012 Feb 05;9(3):270-2
25375876 - PLoS Genet. 2014 Nov 06;10(11):e1004792
17726092 - Physiol Genomics. 2007 Nov 14;31(3):429-40
25437555 - Cell Rep. 2014 Nov 6;9(3):996-1006
22388286 - Nat Methods. 2012 Mar 04;9(4):357-9
25691127 - Nat Commun. 2015 Feb 18;6:6363
20436461 - Nat Biotechnol. 2010 May;28(5):495-501
23391992 - Nat Rev Immunol. 2013 Mar;13(3):190-8
24695404 - Bioinformatics. 2014 Aug 1;30(15):2114-20
27479945 - Aging (Albany NY). 2016 Jul;8(7):1485-512
27690265 - Aging (Albany NY). 2016 Sep 28;8(9):1844-1865
15075390 - Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6062-7
24270890 - Nat Cell Biol. 2013 Dec;15(12):1495-506
23217262 - Cell Metab. 2012 Dec 5;16(6):833-45
15951747 - Nat Rev Genet. 2005 Jul;6(7):544-56
References_xml – volume: 111
  start-page: 16219
  year: 2014
  end-page: 16224
  ident: CR7
  article-title: A circadian gene expression atlas in mammals: implications for biology and medicine
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1408886111
– volume: 22
  start-page: R7
  year: 2013
  end-page: R15
  ident: CR24
  article-title: Age-associated epigenetic drift: implications, and a case of epigenetic thrift?
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddt375
– volume: 26
  start-page: 225
  year: 2011
  end-page: 235
  ident: CR4
  article-title: Circadian rhythms, aging, and life span in mammals
  publication-title: Physiol. (Bethesda)
– volume: 324
  start-page: 930
  year: 2009
  end-page: 935
  ident: CR17
  article-title: Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
  publication-title: Science
  doi: 10.1126/science.1170116
– volume: 17
  year: 2016
  ident: CR33
  article-title: An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1030-0
– volume: 58
  start-page: 295
  year: 1965
  end-page: 300
  ident: CR30
  article-title: The environment and disease: association or causation?
  publication-title: Proc. R. Soc. Med.
– volume: 16
  start-page: 833
  year: 2012
  end-page: 845
  ident: CR14
  article-title: Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome
  publication-title: Cell. Metab.
  doi: 10.1016/j.cmet.2012.11.004
– volume: 8
  start-page: 1485
  year: 2016
  end-page: 1512
  ident: CR34
  article-title: Huntington’s disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
  publication-title: Aging (Albany, NY)
  doi: 10.18632/aging.101005
– volume: 354
  start-page: 994
  year: 2016
  end-page: 999
  ident: CR36
  article-title: Circadian time signatures of fitness and disease
  publication-title: Science
  doi: 10.1126/science.aah4965
– start-page: 1571
  year: 2011
  end-page: 1572
  ident: CR38
  article-title: Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications
  publication-title: Bioinformatics
– volume: 6
  start-page: 544
  year: 2005
  end-page: 556
  ident: CR1
  article-title: Circadian rhythms from multiple oscillators: lessons from diverse organisms
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg1633
– volume: 13
  start-page: 325
  year: 2012
  end-page: 335
  ident: CR3
  article-title: The circadian clock and pathology of the ageing brain
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn3208
– volume: 336
  start-page: 934
  year: 2012
  end-page: 937
  ident: CR18
  article-title: Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution
  publication-title: Science
  doi: 10.1126/science.1220671
– volume: 6
  year: 2015
  ident: CR28
  article-title: Intermediate DNA methylation is a conserved signature of genome regulation
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7363
– volume: 8
  start-page: 1844
  year: 2016
  end-page: 1865
  ident: CR32
  article-title: DNA methylation-based measures of biological age: meta-analysis predicting time to death
  publication-title: Aging (Albany, NY)
  doi: 10.18632/aging.101020
– volume: 28
  start-page: 495
  year: 2010
  end-page: 501
  ident: CR43
  article-title: GREAT improves functional interpretation of cis-regulatory regions
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1630
– volume: 31
  start-page: 429
  year: 2007
  end-page: 440
  ident: CR27
  article-title: Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes
  publication-title: Physiol. Genom.
  doi: 10.1152/physiolgenomics.00060.2007
– volume: 13
  start-page: 190
  year: 2013
  end-page: 198
  ident: CR20
  article-title: Circadian control of the immune system
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3386
– volume: 155
  start-page: 1464
  year: 2013
  end-page: 1478
  ident: CR8
  article-title: Reprogramming of the circadian clock by nutritional challenge
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.034
– volume: 30
  start-page: 2114
  year: 2014
  end-page: 2120
  ident: CR37
  article-title: Trimmomatic: a flexible trimmer for Illumina sequence data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu170
– volume: 418
  start-page: 935
  year: 2002
  end-page: 941
  ident: CR6
  article-title: Coordination of circadian timing in mammals
  publication-title: Nature
  doi: 10.1038/nature00965
– volume: 17
  start-page: 1414
  year: 2010
  end-page: 1421
  ident: CR10
  article-title: The histone methyltransferase MLL1 permits the oscillation of circadian gene expression
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1961
– volume: 332
  start-page: 1436
  year: 2011
  end-page: 1439
  ident: CR9
  article-title: A molecular mechanism for circadian clock negative feedback
  publication-title: Science
  doi: 10.1126/science.1196766
– volume: 101
  start-page: 6062
  year: 2004
  end-page: 6067
  ident: CR40
  article-title: A gene atlas of the mouse and human protein-encoding transcriptomes
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0400782101
– ident: CR42
– volume: 37
  start-page: W202
  year: 2009
  end-page: W208
  ident: CR45
  article-title: MEME SUITE: tools for motif discovery and searching
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkp335
– volume: 10
  start-page: e0118101
  year: 2015
  ident: CR12
  article-title: Daily variation in global and local DNA methylation in mouse livers
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0118101
– volume: 9
  start-page: 764
  year: 2008
  end-page: 775
  ident: CR2
  article-title: The genetics of mammalian circadian order and disorder: implications for physiology and disease
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2430
– volume: 6
  start-page: e21800
  year: 2011
  ident: CR44
  article-title: REVIGO summarizes and visualizes long lists of gene ontology terms
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0021800
– volume: 17
  start-page: 377
  year: 2014
  end-page: 382
  ident: CR13
  article-title: Circadian behavior is light-reprogrammed by plastic DNA methylation
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3651
– volume: 24
  start-page: 336
  year: 2005
  end-page: 346
  ident: CR23
  article-title: Myc represses transcription through recruitment of DNA methyltransferase corepressor
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600509
– volume: 10
  start-page: 447
  year: 1996
  end-page: 460
  ident: CR22
  article-title: Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc
  publication-title: Genes Dev.
  doi: 10.1101/gad.10.4.447
– volume: 15
  start-page: 1495
  year: 2013
  end-page: 1506
  ident: CR35
  article-title: Senescent cells harbour features of the cancer epigenome
  publication-title: Nat. Cell. Biol.
  doi: 10.1038/ncb2879
– volume: 10
  start-page: e1004792
  year: 2014
  ident: CR15
  article-title: 24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1004792
– volume: 5
  year: 2014
  ident: CR19
  article-title: Circadian rhythm reprogramming during lung inflammation
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms5753
– volume: 153
  start-page: 1194
  year: 2013
  end-page: 1217
  ident: CR29
  article-title: The hallmarks of aging
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.039
– volume: 9
  start-page: 357
  year: 2012
  end-page: 359
  ident: CR39
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 17
  start-page: 1115
  year: 2003
  end-page: 1129
  ident: CR21
  article-title: Genomic targets of the human c-Myc protein
  publication-title: Genes Dev.
  doi: 10.1101/gad.1067003
– volume: 17
  year: 2016
  ident: CR25
  article-title: Epigenetic assimilation in the aging human brain
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-0946-8
– volume: 9
  start-page: 270
  year: 2012
  end-page: 272
  ident: CR16
  article-title: Library-free methylation sequencing with bisulfite padlock probes
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1871
– volume: 41
  start-page: D1009
  year: 2013
  end-page: D1013
  ident: CR41
  article-title: CircaDB: a database of mammalian circadian gene expression profiles
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks1161
– volume: 338
  start-page: 349
  year: 2012
  end-page: 354
  ident: CR11
  article-title: Transcriptional architecture and chromatin landscape of the core circadian clock in mammals
  publication-title: Science
  doi: 10.1126/science.1226339
– volume: 9
  start-page: 996
  year: 2014
  end-page: 1006
  ident: CR26
  article-title: Changes in nucleosome occupancy associated with metabolic alterations in aged mammalian liver
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.09.048
– volume: 14
  year: 2013
  ident: CR31
  article-title: DNA methylation age of human tissues and cell types
  publication-title: Genome Biol.
  doi: 10.1186/gb-2013-14-10-r115
– volume: 38
  start-page: 369
  year: 2006
  end-page: 374
  ident: CR5
  article-title: Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions
  publication-title: Nat. Genet.
  doi: 10.1038/ng1738
– volume: 14
  year: 2013
  ident: 3073_CR31
  publication-title: Genome Biol.
  doi: 10.1186/gb-2013-14-10-r115
– volume: 153
  start-page: 1194
  year: 2013
  ident: 3073_CR29
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.039
– ident: 3073_CR42
– volume: 17
  start-page: 1414
  year: 2010
  ident: 3073_CR10
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1961
– volume: 41
  start-page: D1009
  year: 2013
  ident: 3073_CR41
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks1161
– volume: 17
  start-page: 1115
  year: 2003
  ident: 3073_CR21
  publication-title: Genes Dev.
  doi: 10.1101/gad.1067003
– volume: 31
  start-page: 429
  year: 2007
  ident: 3073_CR27
  publication-title: Physiol. Genom.
  doi: 10.1152/physiolgenomics.00060.2007
– volume: 58
  start-page: 295
  year: 1965
  ident: 3073_CR30
  publication-title: Proc. R. Soc. Med.
– volume: 8
  start-page: 1844
  year: 2016
  ident: 3073_CR32
  publication-title: Aging (Albany, NY)
  doi: 10.18632/aging.101020
– volume: 324
  start-page: 930
  year: 2009
  ident: 3073_CR17
  publication-title: Science
  doi: 10.1126/science.1170116
– volume: 30
  start-page: 2114
  year: 2014
  ident: 3073_CR37
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu170
– volume: 26
  start-page: 225
  year: 2011
  ident: 3073_CR4
  publication-title: Physiol. (Bethesda)
– volume: 10
  start-page: e0118101
  year: 2015
  ident: 3073_CR12
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0118101
– volume: 17
  year: 2016
  ident: 3073_CR33
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1030-0
– volume: 28
  start-page: 495
  year: 2010
  ident: 3073_CR43
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1630
– volume: 418
  start-page: 935
  year: 2002
  ident: 3073_CR6
  publication-title: Nature
  doi: 10.1038/nature00965
– volume: 9
  start-page: 764
  year: 2008
  ident: 3073_CR2
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2430
– volume: 13
  start-page: 190
  year: 2013
  ident: 3073_CR20
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3386
– volume: 16
  start-page: 833
  year: 2012
  ident: 3073_CR14
  publication-title: Cell. Metab.
  doi: 10.1016/j.cmet.2012.11.004
– volume: 10
  start-page: 447
  year: 1996
  ident: 3073_CR22
  publication-title: Genes Dev.
  doi: 10.1101/gad.10.4.447
– volume: 15
  start-page: 1495
  year: 2013
  ident: 3073_CR35
  publication-title: Nat. Cell. Biol.
  doi: 10.1038/ncb2879
– volume: 101
  start-page: 6062
  year: 2004
  ident: 3073_CR40
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0400782101
– volume: 17
  year: 2016
  ident: 3073_CR25
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-0946-8
– volume: 8
  start-page: 1485
  year: 2016
  ident: 3073_CR34
  publication-title: Aging (Albany, NY)
  doi: 10.18632/aging.101005
– volume: 6
  start-page: 544
  year: 2005
  ident: 3073_CR1
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg1633
– volume: 155
  start-page: 1464
  year: 2013
  ident: 3073_CR8
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.034
– volume: 10
  start-page: e1004792
  year: 2014
  ident: 3073_CR15
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1004792
– volume: 336
  start-page: 934
  year: 2012
  ident: 3073_CR18
  publication-title: Science
  doi: 10.1126/science.1220671
– volume: 24
  start-page: 336
  year: 2005
  ident: 3073_CR23
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600509
– volume: 38
  start-page: 369
  year: 2006
  ident: 3073_CR5
  publication-title: Nat. Genet.
  doi: 10.1038/ng1738
– volume: 111
  start-page: 16219
  year: 2014
  ident: 3073_CR7
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1408886111
– volume: 9
  start-page: 270
  year: 2012
  ident: 3073_CR16
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1871
– volume: 37
  start-page: W202
  year: 2009
  ident: 3073_CR45
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkp335
– volume: 13
  start-page: 325
  year: 2012
  ident: 3073_CR3
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn3208
– volume: 338
  start-page: 349
  year: 2012
  ident: 3073_CR11
  publication-title: Science
  doi: 10.1126/science.1226339
– volume: 9
  start-page: 357
  year: 2012
  ident: 3073_CR39
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 332
  start-page: 1436
  year: 2011
  ident: 3073_CR9
  publication-title: Science
  doi: 10.1126/science.1196766
– volume: 6
  year: 2015
  ident: 3073_CR28
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7363
– volume: 5
  year: 2014
  ident: 3073_CR19
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms5753
– volume: 354
  start-page: 994
  year: 2016
  ident: 3073_CR36
  publication-title: Science
  doi: 10.1126/science.aah4965
– volume: 17
  start-page: 377
  year: 2014
  ident: 3073_CR13
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3651
– volume: 22
  start-page: R7
  year: 2013
  ident: 3073_CR24
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddt375
– volume: 9
  start-page: 996
  year: 2014
  ident: 3073_CR26
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.09.048
– volume: 6
  start-page: e21800
  year: 2011
  ident: 3073_CR44
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0021800
– start-page: 1571
  volume-title: Bioinformatics
  year: 2011
  ident: 3073_CR38
– reference: 20436461 - Nat Biotechnol. 2010 May;28(5):495-501
– reference: 21680841 - Science. 2011 Jun 17;332(6036):1436-9
– reference: 24531307 - Nat Neurosci. 2014 Mar;17(3):377-82
– reference: 23746838 - Cell. 2013 Jun 6;153(6):1194-217
– reference: 22936566 - Science. 2012 Oct 19;338(6105):349-54
– reference: 19458158 - Nucleic Acids Res. 2009 Jul;37(Web Server issue):W202-8
– reference: 22395806 - Nat Rev Neurosci. 2012 Mar 07;13(5):325-35
– reference: 16474407 - Nat Genet. 2006 Mar;38(3):369-74
– reference: 21493656 - Bioinformatics. 2011 Jun 1;27(11):1571-2
– reference: 15075390 - Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6062-7
– reference: 27690265 - Aging (Albany NY). 2016 Sep 28;8(9):1844-1865
– reference: 23180795 - Nucleic Acids Res. 2013 Jan;41(Database issue):D1009-13
– reference: 21789182 - PLoS One. 2011;6(7):e21800
– reference: 24138928 - Genome Biol. 2013;14(10):R115
– reference: 23391992 - Nat Rev Immunol. 2013 Mar;13(3):190-8
– reference: 18802415 - Nat Rev Genet. 2008 Oct;9(10):764-75
– reference: 25691127 - Nat Commun. 2015 Feb 18;6:6363
– reference: 19372391 - Science. 2009 May 15;324(5929):930-5
– reference: 14283879 - Proc R Soc Med. 1965 May;58:295-300
– reference: 27122015 - Genome Biol. 2016 Apr 28;17 :76
– reference: 25375876 - PLoS Genet. 2014 Nov 06;10(11):e1004792
– reference: 22388286 - Nat Methods. 2012 Mar 04;9(4):357-9
– reference: 24270890 - Nat Cell Biol. 2013 Dec;15(12):1495-506
– reference: 25208554 - Nat Commun. 2014 Sep 11;5:4753
– reference: 12198538 - Nature. 2002 Aug 29;418(6901):935-41
– reference: 15951747 - Nat Rev Genet. 2005 Jul;6(7):544-56
– reference: 21841071 - Physiology (Bethesda). 2011 Aug;26(4):225-35
– reference: 15616584 - EMBO J. 2005 Jan 26;24(2):336-46
– reference: 12695333 - Genes Dev. 2003 May 1;17(9):1115-29
– reference: 24695404 - Bioinformatics. 2014 Aug 1;30(15):2114-20
– reference: 17726092 - Physiol Genomics. 2007 Nov 14;31(3):429-40
– reference: 22306810 - Nat Methods. 2012 Feb 05;9(3):270-2
– reference: 23918660 - Hum Mol Genet. 2013 Oct 15;22(R1):R7-R15
– reference: 25689298 - PLoS One. 2015 Feb 17;10(2):e0118101
– reference: 23217262 - Cell Metab. 2012 Dec 5;16(6):833-45
– reference: 21113167 - Nat Struct Mol Biol. 2010 Dec;17(12):1414-21
– reference: 25349387 - Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16219-24
– reference: 27885004 - Science. 2016 Nov 25;354(6315):994-999
– reference: 24360271 - Cell. 2013 Dec 19;155(7):1464-78
– reference: 27511193 - Genome Biol. 2016 Aug 11;17 (1):171
– reference: 22539555 - Science. 2012 May 18;336(6083):934-7
– reference: 27479945 - Aging (Albany NY). 2016 Jul;8(7):1485-512
– reference: 8600028 - Genes Dev. 1996 Feb 15;10(4):447-60
– reference: 25437555 - Cell Rep. 2014 Nov 6;9(3):996-1006
SSID ssj0000391844
Score 2.4545102
Snippet Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities....
While epigenetic factors have been implicated in the circadian rhythm, the detection of circadian cytosine modifications has remained elusive. Here the authors...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 644
SubjectTerms 38/22
38/77
38/88
38/90
42/47
49/23
631/136/7
631/337/176/1988
631/80/105
64/60
Aging
Biodiversity
Circadian rhythm
Circadian rhythms
Cytosine
Epigenetics
Humanities and Social Sciences
Machinery and equipment
multidisciplinary
Oscillations
Proteomics
Science
Science (multidisciplinary)
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlUOilNH26SYsKvbUi0dPSMQ0JodCeGshNyNKIGFJv2DiF_PuMZO82m74uvRlbsod5SCNr9H2EvHfa8aQ7wSJvDVPROBaCMSy6oDLOsW2obA1fvpqTU_X5TJ_dofoqNWETPPCkuD3rsitsWFrGrIxuHdcAIrTKZAfOVPRSnPPuLKbqGCwdLl3UfEpmX9q9K1XHhH1eTpShX7N2YyaqgP2_yzJ_LZa8t2NaJ6LjJ-TxnEHSg0nybfIAhqfk4cQpefOM9Ic346IUs9Pvi1TqgKZfchQKE3Y_0tgvY8UjoAXG8mIuhaPjeRhpWALtBxywfkDCCwqXBauzHHOkaVW_QcOQaKU2ek5Oj4--HZ6wmU-BRczLRiaDzFmLBJ2xhneitaCjEIFD4Yew0eQuQ4QcRLCQNc86BcwHMgRwueSFL8jWsBjgFaFR6tTlznRSGmVSxCFTKBkdvsxZcKohfKVbH2ew8cJ5ceHrpre0frKHR3v4ag_fNuTDus_lBLXx19afisnWLQtMdr2BzuNn5_H_cp6G7K4M7ufYvSrEnBxXofidhrxbP8aoK1spYYDFdW0jBCbLXDTk5eQfa0mEU5glSZSw3fCcDVE3nwz9eUX21rZgH2HPjysf-ynWn1Xx-n-oYoc8EjU4BONyl2yNy2t4g_nW2L2toXULQ6wl3w
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4k2gICNxA6vEb59QW1FVSHCi0t4sx7FppJIsuylS_z0ex0m1PHqL4occz3g8GY-_D6G3Rpi6FQ0lvlaScC8NcU5K4o3jMe2xymW2hi9f5ekZ_7wSqxJw25a0ytkmZkPdDh5i5AeQ-5P-DZJOflz_JMAaBaerhULjNroD0GWQ0qVWaomxAPq55rzclfnA9MGWZ8uQuiJZu4na2Y8ybP-_fM2_Uyb_ODfN29HJA3S_-JH4cBL8Q3Qr9I_Q3YlZ8uox6o6vxgFS2vGPoYVsoCkwhwPwYXcj9t3GZ1QCDGCWFyUhDo_nbsRuE3DXJ7P1K7TpAYc1IHbCZUfczlkc2PUtzgRHT9DZyadvx6eksCoQn7yzkTDHYhS0DY3Usm6o0kF4Sl0dgCVCexmbGHyIjjodoqijaF3yCmJwwUTwDp-ivX7ow3OEPRNtExvZMCa5bH0ynJQzb1JnRgfDK1TPc2t9gRwH5osLm4--mbaTPGySh83ysKpC75Y26wlw48baRyCypSaAZecXw-a7LWvPahMNEKoJ5iOXQplahECd4jKaYKSo0P4scFtW8NZe61uF3izFae3BgYrrw3CZ61CaXOaaVujZpB_LSKjhyVdiaYRqR3N2hrpb0nfnGd9baEBASi3fzzp2Paz_T8WLm7_iJbpHs9pTUrN9tDduLsOr5E-Nzeu8aH4DSk0eag
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature OA Free Journals (WRLC)
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1da9YwFA5zIngjzq91bhLBOy0un00u9WVjCHrlYHclTU5cYbbjXSfs3y8n_ZBXp7C70ibtIeec5DQ553kIeWeVZUE1vPSs0qX02pbOaV1662RMa2zlMlvD12_65FR-OVNnW4TPtTA5aT9DWuZpes4O-3gls0sfMiwIS2ZZVg_IQ4RuR6te6dWyr4KI50bKqT7mUJg7um6sQRmq_6748u80yT_OSvMSdPyUPJliR_pplHaHbEH3jDwa2SRvnpN2dTP0mMZOf_YBM4DGzTgKyIHdDtS3a5-RCCgCWF5MSXB0OHcDdWugbZemql8Q0gWFS0TpxAJHGubMDeq6QDOp0Qtyenz0fXVSTkwKpU8R2VAKJ2JUPECjjWYNrwwoz7ljgMwQxuvYRPAQHXcGomJRBZcigQgObMSI8CXZ7voOdgn1QoUmNroRQksdfJosuRTeppdZA1YWhM1jW_sJZhzZLi7qfNwtTD3qo076qLM-6qog75c-lyPIxn9bf0aVLS0RIDvf6Nc_6slgamOjRRI1JXyUWlWWKQDuKqmjBatVQfZnhdeT114hJSdL_5_pOwV5uzxO_oaHKK6D_jq34TyFyYwX5NVoH4sk3MoUH4kkYbVhORuibj7p2vOM6a0Moh6lnh9mG_st1r-HYu9-zV-Txzy7AS-Z2Cfbw_oaDlJMNTRvshPdArqwHEQ
  priority: 102
  providerName: Springer Nature
Title Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging
URI https://link.springer.com/article/10.1038/s41467-018-03073-7
https://www.ncbi.nlm.nih.gov/pubmed/29440637
https://www.proquest.com/docview/2001899030
https://www.proquest.com/docview/2002216112
https://pubmed.ncbi.nlm.nih.gov/PMC5811577
https://doaj.org/article/89f9083153cf4657915ee2a746f9e965
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELf2ISReEN90jMpIvEFg_o4fEOqqlanSJgRU6lvkOPZWqSQjyyb633N2kqJCQeIliRLHsXx3vp_j8_0QeqWFJoXIaWKJkgm3UifGSJlYbbgHH6tMZGs4O5enMz6di_kO6umOug683jq1C3xSs3r59sf31Qcw-PftlvH03TWP5n5EwmYxUNlE7aJ98EwqGOpZB_fjyMw0TGjCQjM94iQB3826fTTbq9nwVTGl_zYc-mc45W9rqtFVTe6jex3GxKNWKR6gHVc-RHda1snVI7QYr5oqhLvjb1URIoXan3bYBa7sRYPtorYxYwEOiS6XXbAcbi5Ng03t8KKEIe3WFXCB3VXI5hk2QuKij_DApixwJD96jGaTk6_j06RjXEgsILcmYYZ5L2jhcplKklOVOmEpNcQFBonUSp97Z5031KTOC-JFYQAxeGec9gE5PkF7ZVW6ZwhbJorc5zJnTHJZWBhUKWdWQ2U6dZoPEOn7NrNdOvLAirHM4rI4S7NWHhnII4vyyNQAvV6_c9Um4_hn6eMgsnXJkEg73qjqi6yzyyzVXgeyNcGs51IoTYRz1CguvXZaigE67AWe9coZqDsJzFPhOwP0cv0Y7DIstpjSVTexDKUApwkdoKetfqxbQjUHHMWghWpDczaauvmkXFzG3N8iDdmR4M03vY79atbfu-LgvzruObpLoxXQhLBDtNfUN-4FQK8mH6JdNVdwTCcfh2h_NJp-mcL5-OT802e4O5bjYfypMYx29xMaHy4J
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9QwFLZKEYILYi2BAkaCE1htvCU-IASFakqXUyvNzTjOM41UkmEmBc2f4jdiO0s1LL31Npo40YvfGvv5-xB6qYRKS1FQYtNMEm6lIsZISawy3Pkcm5nI1nB4JCcn_PNUTNfQr-EsTGirHGJiDNRlY8Ma-Vbo_fHfBt4m382-k8AaFXZXBwqNziz2YfnTf7It3u599Pp9Renup-OdCelZBYj11UlLmGHOCVpCIXOZFjTLQVhKTQqBJSG30hUOLDhDTQ5OpE6UxmdFBwaUC9WRf-41dN0n3u3gUdk0G9d0Atp6znl_Nmeb5VsLHiORF51EbyLZSv6LNAH_qm3_btH8Y582pr_dO-h2X7fi952h3UVrUN9DNzomy-V9VO0s2ya00ONvTRm6j7qFQAyBf7tqsa3mNqIg4ACeedY34OH21LTYzAFXtQ-TP6D0PzDMAkJoOFyJy6FrBJu6xJFQ6QE6uZL5fojW66aGRwhbJsrCFbJgTHJZWh-oKWdW-YepHBRPUDrMrbY9xHlg2jjTcaud5brTh_b60FEfOkvQ6_GeWQfwcenoD0Fl48gAzh3_aOZfde_rOldOBQI3wazjUmQqFQDUZFw6BUqKBG0OCtd9xFjoC_tO0Ivxsvf1sIFjamjO4xhKfYme0gRtdPYxSkIV97UZ8xJmK5azIurqlbo6jXjiIg-IS_7ON4ONXYj1_6l4fPlbPEc3J8eHB_pg72j_CbpFowtQkrJNtN7Oz-Gpr-Xa4ll0IIy-XLXH_gYfJV39
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3LbtQwFLVKEYgN4s1AASPBCqxp_IwXCEHLqKVQsaDS7Izj2DRSSYaZFDS_xtfh6yRTDY_uuotix3J8H762r89B6JkWOitFQYnLlCTcSU2slZI4bXmIc6yyia3h46HcO-Lvp2K6gX4Nd2EgrXLwiclRl42DPfIx5P7EtUHUyXHo0yI-7U5ez74TYJCCk9aBTqNTkQO__BmXb4tX-7tR1s8pnbz7vLNHeoYB4mKk0hJmWQiClr6QucwKqnIvHKU288CYkDsZiuCdD5ba3AeRBVHaOEMGb70OECnFdi-hy4qJDGxMTdVqfweQ13PO-3s62ywfL3jySvE3SLIsotbmwkQZ8K849-90zT_ObNNUOLmBrvcxLH7TKd1NtOHrW-hKx2q5vI2qnWXbQDo9_taUkInUbQpiD1zcVYtdNXcJEQEDkOZJn4yH22PbYjv3uKqjy_zhy_iA_QzQQuGiJS6HDBJs6xIncqU76OhCxvsu2qyb2t9H2DFRFqGQBWOSy9JFp005czo2pnOv-Qhlw9ga18OdA-vGiUnH7iw3nTxMlIdJ8jBqhF6svpl1YB_n1n4LIlvVBKDu9KKZfzW93ZtcBw1kboK5wKVQOhPeU6u4DNprKUZoaxC46b3Hwpzp-gg9XRVHu4fDHFv75jTVoTSG6xkdoXudfqx6QjWPcRqLPVRrmrPW1fWSujpO2OIiB_Sl-OXLQcfOuvX_oXhw_l88QVejrZoP-4cHD9E1miyAkoxtoc12fuofxbCuLR4n-8Hoy0Ub7G9RBGIz
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cytosine+modifications+exhibit+circadian+oscillations+that+are+involved+in+epigenetic+diversity+and+aging&rft.jtitle=Nature+communications&rft.au=Oh%2C+Gabriel&rft.au=Ebrahimi%2C+Sasha&rft.au=Carlucci%2C+Matthew&rft.au=Zhang%2C+Aiping&rft.date=2018-02-13&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=9&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-018-03073-7&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41467_018_03073_7
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon