Improved efficacy and in vivo cellular properties of human embryonic stem cell derivative in a preclinical model of bladder pain syndrome

• Published in: Scientific reports Vol. 7; no. 1; pp. 8872 - 16
• Main Authors: Kim, Aram, Yu, Hwan Yeul, Lim, Jisun, Ryu, Chae-Min, Kim, Yong Hwan, Heo, Jinbeom, Han, Ju-Young, Lee, Seungun, Bae, Yoon Sung, Kim, Jae Young, Bae, Dong-Jun, Kim, Sang-Yeob, Noh, Byeong-Joo, Hong, Ki-Sung, Han, Ji-Yeon, Lee, Sang Wook, Song, Miho, Chung, Hyung-Min, Kim, Jun Ki, Shin, Dong-Myung, Choo, Myung-Soo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.08.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/100; 13/51; 14/19; 38; 38/77; 59/5; 631/532/2063; 631/532/2074; Animals; Apoptosis; Biomarkers; Bladder; Bone marrow; Cystitis; Cystitis, Interstitial - etiology; Cystitis, Interstitial - metabolism; Cystitis, Interstitial - physiopathology; Cystitis, Interstitial - therapy; Disease Models, Animal; Fibrosis; Fluorescent Antibody Technique; Graft rejection; Human Embryonic Stem Cells - cytology; Human Embryonic Stem Cells - metabolism; Humanities and Social Sciences; Humans; Hypersensitivity; Immunohistochemistry; Injection; Intercellular Signaling Peptides and Proteins - metabolism; Karyotype; Mesenchymal Stem Cell Transplantation; Mesenchyme; Metastases; Microscopy, Confocal; Molecular Imaging; multidisciplinary; Pain; Pain - etiology; Pain - metabolism; Pain - physiopathology; Pain Management; Pelvis; Science; Science (multidisciplinary); Signal Transduction; Stem cell transplantation; Stem cells; Syndrome; Treatment Outcome; Tumorigenesis; Urinary bladder; Urothelium; Wnt Proteins - metabolism

Interstitial cystitis/bladder pain syndrome (IC/BPS) is an intractable disease characterized by severe pelvic pain and urinary frequency. Mesenchymal stem cell (MSC) therapy is a promising approach to treat incurable IC/BPS. Here, we show greater therapeutic efficacy of human embryonic stem cell (hE...