Vascular endothelial growth factor (VEGF) polymorphism rs3025039 and atherosclerosis among older with hypertension

• Published in: Scientific reports Vol. 12; no. 1; pp. 5564 - 6
• Main Authors: Shimizu, Yuji, Arima, Kazuhiko, Noguchi, Yuko, Yamanashi, Hirotomo, Kawashiri, Shin-Ya, Nobusue, Kenichi, Nonaka, Fumiaki, Aoyagi, Kiyoshi, Nagata, Yasuhiro, Maeda, Takahiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4019/592/16; 692/499; 692/53; 692/53/2423; Aged; Aged, 80 and over; Alleles; Angiogenesis; Arteriosclerosis; Atherosclerosis; Atherosclerosis - complications; Atherosclerosis - genetics; Cardiovascular diseases; Carotid Intima-Media Thickness; Cross-Sectional Studies; Gene polymorphism; Health risks; Humanities and Social Sciences; Humans; Hypertension; Hypertension - complications; Hypertension - genetics; Middle Aged; multidisciplinary; Polymorphism; Risk factors; Science; Science (multidisciplinary); Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-09486-1

Angiogenesis inhibition therapy causes hypertension by increasing peripheral vascular resistance. Vasa vasorum angiogenesis plays a crucial role in the development of atherosclerosis. Since vascular endothelial growth factor (VEGF), which contributes to the progress of angiogenesis, is reported to b...