In vivo characterization of target cells for acute elephant endotheliotropic herpesvirus (EEHV) infection in Asian elephants (Elephas maximus)

• Published in: Scientific reports Vol. 10; no. 1; p. 11402
• Main Authors: Guntawang, Thunyamas, Sittisak, Tidaratt, Srivorakul, Saralee, Kochagul, Varankpicha, Photichai, Kornravee, Thitaram, Chatchote, Sthitmatee, Nattawooti, Hsu, Wei-Li, Pringproa, Kidsadagon
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.07.2020; Nature Publishing Group
• Subjects: 631/326/596/1553; 631/326/596/2564; 692/420/254; Animals; Antigens; Antigens, Viral - analysis; Bone marrow; Bone Marrow Cells - virology; Digestive System - virology; DNA-directed DNA polymerase; DNA-Directed DNA Polymerase - analysis; DNA-Directed DNA Polymerase - chemistry; Elephants; Elephants - virology; Elephas maximus; Endothelial Cells - virology; Female; Gastrointestinal tract; Heart - virology; Hemorrhage; Hemorrhagic disease; Hemorrhagic Disorders - veterinary; Hemorrhagic Disorders - virology; Herpesviridae - immunology; Herpesviridae - isolation & purification; Herpesviridae - physiology; Herpesviridae Infections - veterinary; Herpesviridae Infections - virology; Humanities and Social Sciences; Infections; Infectious diseases; Lymph Nodes - virology; Male; Models, Molecular; Monocytes; Monocytes - virology; multidisciplinary; Myocytes, Smooth Muscle - virology; Nervous System - virology; Organ Specificity; Polyclonal antibodies; Protein Conformation; Recombinant Proteins - chemistry; Replication; Salivary gland; Salivary Glands - virology; Science; Science (multidisciplinary); Smooth muscle; Structural proteins; Viral Proteins - analysis; Viral Tropism

Elephant endotheliotropic herpesvirus-hemorrhagic disease (EEHV-HD) is a dangerous viral infectious disease in young Asian elephants. Despite hypotheses underlying pathogenesis of the disease, it is unclear which cell types the virus targets during acute or persistent infections. This study investig...