In vivo characterization of target cells for acute elephant endotheliotropic herpesvirus (EEHV) infection in Asian elephants (Elephas maximus)
Elephant endotheliotropic herpesvirus-hemorrhagic disease (EEHV-HD) is a dangerous viral infectious disease in young Asian elephants. Despite hypotheses underlying pathogenesis of the disease, it is unclear which cell types the virus targets during acute or persistent infections. This study investig...
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| Published in | Scientific reports Vol. 10; no. 1; p. 11402 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Nature Publishing Group UK
09.07.2020
Nature Publishing Group |
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| Abstract | Elephant endotheliotropic herpesvirus-hemorrhagic disease (EEHV-HD) is a dangerous viral infectious disease in young Asian elephants. Despite hypotheses underlying pathogenesis of the disease, it is unclear which cell types the virus targets during acute or persistent infections. This study investigated the tissues and target cells permissive for EEHV infection and replication in vivo. Rabbit polyclonal antibodies against the non-structural proteins of EEHV, DNA polymerase (EEHV DNAPol), were generated and validated. These were used to examine EEHV infection and replication in various tissues of acute EEHV-HD cases and compared to an EEHV-negative control. The results indicated that viral antigens were distributed throughout the epithelia of the alimentary tract and salivary glands, endothelia and smooth muscle cells, and monocytic lineage cells of the EEHV-infected elephants. Moreover, EEHV DNAPol proteins were also found in the bone marrow cells of the EEHV1A-HD and EEHV1A/4-HD cases. This study demonstrated for the first time the target cells that favor in vivo EEHV replication during acute infection, providing a promising foundation for investigating EEHV propagation in vitro. |
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| AbstractList | Elephant endotheliotropic herpesvirus-hemorrhagic disease (EEHV-HD) is a dangerous viral infectious disease in young Asian elephants. Despite hypotheses underlying pathogenesis of the disease, it is unclear which cell types the virus targets during acute or persistent infections. This study investigated the tissues and target cells permissive for EEHV infection and replication in vivo. Rabbit polyclonal antibodies against the non-structural proteins of EEHV, DNA polymerase (EEHV DNAPol), were generated and validated. These were used to examine EEHV infection and replication in various tissues of acute EEHV-HD cases and compared to an EEHV-negative control. The results indicated that viral antigens were distributed throughout the epithelia of the alimentary tract and salivary glands, endothelia and smooth muscle cells, and monocytic lineage cells of the EEHV-infected elephants. Moreover, EEHV DNAPol proteins were also found in the bone marrow cells of the EEHV1A-HD and EEHV1A/4-HD cases. This study demonstrated for the first time the target cells that favor in vivo EEHV replication during acute infection, providing a promising foundation for investigating EEHV propagation in vitro. Elephant endotheliotropic herpesvirus-hemorrhagic disease (EEHV-HD) is a dangerous viral infectious disease in young Asian elephants. Despite hypotheses underlying pathogenesis of the disease, it is unclear which cell types the virus targets during acute or persistent infections. This study investigated the tissues and target cells permissive for EEHV infection and replication in vivo. Rabbit polyclonal antibodies against the non-structural proteins of EEHV, DNA polymerase (EEHV DNAPol), were generated and validated. These were used to examine EEHV infection and replication in various tissues of acute EEHV-HD cases and compared to an EEHV-negative control. The results indicated that viral antigens were distributed throughout the epithelia of the alimentary tract and salivary glands, endothelia and smooth muscle cells, and monocytic lineage cells of the EEHV-infected elephants. Moreover, EEHV DNAPol proteins were also found in the bone marrow cells of the EEHV1A-HD and EEHV1A/4-HD cases. This study demonstrated for the first time the target cells that favor in vivo EEHV replication during acute infection, providing a promising foundation for investigating EEHV propagation in vitro.Elephant endotheliotropic herpesvirus-hemorrhagic disease (EEHV-HD) is a dangerous viral infectious disease in young Asian elephants. Despite hypotheses underlying pathogenesis of the disease, it is unclear which cell types the virus targets during acute or persistent infections. This study investigated the tissues and target cells permissive for EEHV infection and replication in vivo. Rabbit polyclonal antibodies against the non-structural proteins of EEHV, DNA polymerase (EEHV DNAPol), were generated and validated. These were used to examine EEHV infection and replication in various tissues of acute EEHV-HD cases and compared to an EEHV-negative control. The results indicated that viral antigens were distributed throughout the epithelia of the alimentary tract and salivary glands, endothelia and smooth muscle cells, and monocytic lineage cells of the EEHV-infected elephants. Moreover, EEHV DNAPol proteins were also found in the bone marrow cells of the EEHV1A-HD and EEHV1A/4-HD cases. This study demonstrated for the first time the target cells that favor in vivo EEHV replication during acute infection, providing a promising foundation for investigating EEHV propagation in vitro. |
| ArticleNumber | 11402 |
| Author | Photichai, Kornravee Thitaram, Chatchote Kochagul, Varankpicha Pringproa, Kidsadagon Sittisak, Tidaratt Srivorakul, Saralee Guntawang, Thunyamas Hsu, Wei-Li Sthitmatee, Nattawooti |
| Author_xml | – sequence: 1 givenname: Thunyamas surname: Guntawang fullname: Guntawang, Thunyamas organization: Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University – sequence: 2 givenname: Tidaratt surname: Sittisak fullname: Sittisak, Tidaratt organization: Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University – sequence: 3 givenname: Saralee surname: Srivorakul fullname: Srivorakul, Saralee organization: Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Veterinary Diagnostic Laboratory, Faculty of Veterinary Medicine, Chiang Mai University – sequence: 4 givenname: Varankpicha surname: Kochagul fullname: Kochagul, Varankpicha organization: Veterinary Diagnostic Laboratory, Faculty of Veterinary Medicine, Chiang Mai University – sequence: 5 givenname: Kornravee surname: Photichai fullname: Photichai, Kornravee organization: Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Veterinary Diagnostic Laboratory, Faculty of Veterinary Medicine, Chiang Mai University – sequence: 6 givenname: Chatchote surname: Thitaram fullname: Thitaram, Chatchote organization: Center of Excellence in Elephant and Wildlife Research, Chiang Mai University, Department of Companion Animals and Wildlife Clinics, Faculty of Veterinary Medicine, Chiang Mai University – sequence: 7 givenname: Nattawooti surname: Sthitmatee fullname: Sthitmatee, Nattawooti organization: Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University – sequence: 8 givenname: Wei-Li surname: Hsu fullname: Hsu, Wei-Li organization: Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University – sequence: 9 givenname: Kidsadagon surname: Pringproa fullname: Pringproa, Kidsadagon email: kidsadagon.p@cmu.ac.th organization: Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Center of Excellence in Elephant and Wildlife Research, Chiang Mai University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32647124$$D View this record in MEDLINE/PubMed |
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| Title | In vivo characterization of target cells for acute elephant endotheliotropic herpesvirus (EEHV) infection in Asian elephants (Elephas maximus) |
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