Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling

• Published in: Nature communications Vol. 9; no. 1; pp. 5105 - 16
• Main Authors: Liu, Shu-Chen, Hsu, Tien, Chang, Yu-Sun, Chung, An-Ko, Jiang, Shih Sheng, OuYang, Chun-Nan, Yuh, Chiou-Hwa, Hsueh, Chuen, Liu, Ya-Ping, Tsang, Ngan-Ming
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.11.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/106; 13/21; 13/51; 13/95; 14; 14/1; 631/67; 692/4017; 692/4028; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Adhesion; Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Cancer; Epithelial-Mesenchymal Transition - genetics; Epithelial-Mesenchymal Transition - physiology; Female; Focal adhesion kinase; Focal Adhesion Kinase 1 - genetics; Focal Adhesion Kinase 1 - metabolism; Human Umbilical Vein Endothelial Cells; Humanities and Social Sciences; Humans; Immunohistochemistry; Invasiveness; Kinases; Leukemia; Leukemia inhibitory factor; Leukemia Inhibitory Factor - genetics; Leukemia Inhibitory Factor - metabolism; Male; Mesenchyme; Metastases; Metastasis; Mice; Mice, SCID; Middle Aged; Migration; multidisciplinary; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - genetics; Nasopharyngeal Carcinoma - metabolism; Nasopharyngeal Carcinoma - pathology; Nasopharyngeal Neoplasms - genetics; Nasopharyngeal Neoplasms - metabolism; Nasopharyngeal Neoplasms - pathology; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; Neoplasm Metastasis; Paxillin - genetics; Paxillin - metabolism; Phosphoproteins - genetics; Phosphoproteins - metabolism; Receptors, OSM-LIF - genetics; Receptors, OSM-LIF - metabolism; Science; Science (multidisciplinary); Signal Transduction - genetics; Signal Transduction - physiology; Signaling; Throat cancer; Transcription Factors; Xenograft Model Antitumor Assays; Yes-associated protein; Young Adult

Metastasis remains a clinically unsolved issue in nasopharyngeal carcinoma. Here, we report that higher levels of cytoplasmic leukemia inhibitory factor (LIF) and LIF receptor are correlated with poorer metastasis/recurrence-free survival. Further, single nucleotide variations and signal peptide mut...