Circ_0057558 promotes nonalcoholic fatty liver disease by regulating ROCK1/AMPK signaling through targeting miR-206

• Published in: Cell death & disease Vol. 12; no. 9; pp. 809 - 12
• Main Authors: Chen, Xi, Tan, Qing-Qing, Tan, Xin-Rui, Li, Shi-Jun, Zhang, Xing-Xing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.08.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 3' Untranslated regions; 64/60; 692/699; 692/699/1503; AMP-Activated Protein Kinases - metabolism; Animals; Antibodies; Base Sequence; Binding Sites; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell Line, Tumor; Diet, High-Fat; Enzyme-linked immunosorbent assay; Fatty liver; Gene Expression Regulation; Gene Knockdown Techniques; Hepatocytes; High fat diet; Humans; Immunohistochemistry; Immunology; Immunoprecipitation; Life Sciences; Lipogenesis; Lipogenesis - genetics; Liver diseases; Male; Mice; Mice, Inbred C57BL; MicroRNAs - genetics; MicroRNAs - metabolism; mRNA; Non-alcoholic Fatty Liver Disease - genetics; rho-Associated Kinases - metabolism; RNA, Circular - genetics; RNA, Circular - metabolism; Signal Transduction; Triglycerides - metabolism; Western blotting

Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver disorders that is featured by the extensive deposition of fat in the hepatocytes. Current treatments are very limited due to its unclear pathogenesis. Here, we investigated the function of circ_0057558 and miR-206 in...