Chemokine C–C motif ligand 2 overexpression drives tissue-specific metabolic responses in the liver and muscle of mice

• Published in: Scientific reports Vol. 10; no. 1; p. 11954
• Main Authors: Luciano-Mateo, Fedra, Cabré, Noemí, Fernández-Arroyo, Salvador, Baiges-Gaya, Gerard, Hernández-Aguilera, Anna, Rodríguez-Tomàs, Elisabet, Muñoz-Pinedo, Cristina, Menéndez, Javier A., Camps, Jordi, Joven, Jorge
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.07.2020; Nature Publishing Group
• Subjects: 631/45; 631/80; 692/308; 692/4017; 692/699; AMP; AMP-activated protein kinase; Animals; Autophagy; Biopsy; Chemokine CCL2 - genetics; Chemokine CCL2 - metabolism; Chemokines; Citric acid; Energy Metabolism; Gene Expression; Homeostasis; Humanities and Social Sciences; Kinases; Ligands; Liver; Liver - metabolism; Male; Metabolic disorders; Metabolic Networks and Pathways; Metabolic response; Metabolites; Metabolomics; Mice; Mitochondria; Models, Biological; Monocyte chemoattractant protein 1; multidisciplinary; Muscles - metabolism; Organ Specificity; Oxidative phosphorylation; Phenotype; Phosphorylation; Rapamycin; Science; Science (multidisciplinary); Signal Transduction; Steatosis; Therapeutic applications; TOR protein; Tricarboxylic acid cycle

Chemokine (C–C motif) ligand 2 (CCL2) has been associated with chronic metabolic diseases. We aimed to investigate whether Ccl2 gene overexpression is involved in the regulation of signaling pathways in metabolic organs. Biochemical and histological analyses were used to explore tissue damage in cis...