Plectin ensures intestinal epithelial integrity and protects colon against colitis

• Published in: Mucosal immunology Vol. 14; no. 3; pp. 691 - 702
• Main Authors: Krausova, Alzbeta, Buresova, Petra, Sarnova, Lenka, Oyman-Eyrilmez, Gizem, Skarda, Jozef, Wohl, Pavel, Bajer, Lukas, Sticova, Eva, Bartonova, Lenka, Pacha, Jiri, Koubkova, Gizela, Prochazka, Jan, Spörrer, Marina, Dürrbeck, Christopher, Stehlikova, Zuzana, Vit, Martin, Ziolkowska, Natalia, Sedlacek, Radislav, Jirak, Daniel, Kverka, Miloslav, Wiche, Gerhard, Fabry, Ben, Korinek, Vladimir, Gregor, Martin
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.05.2021; Elsevier Limited
• Subjects: Adult; Aged; Allergology; Animals; Antibodies; Biomedical and Life Sciences; Biomedicine; Cell junctions; Colitis - metabolism; Colitis - prevention & control; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - prevention & control; Colon; Colon - pathology; Desmosomes - genetics; Desmosomes - metabolism; Disease Models, Animal; Epithelial cells; Epithelium; Female; Filaments; Gastroenterology; Hemidesmosomes; Homeostasis; Humans; Immunology; Inflammatory bowel disease; Inflammatory bowel diseases; Intermediate filaments; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Intestine; Keratin; Keratins - metabolism; Male; Membrane permeability; Mice; Mice, Knockout; Middle Aged; Nutrient deficiency; Plectin - genetics; Plectin - metabolism; Ulcerative colitis; Young Adult

Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability through the integration of intermediate filaments (IFs) with cell junctions. Here, we hypothesize that plectin-controlled cytoarchitecture is a critical determinant of the intestinal barrier function and homeo...