Dissection of the bone marrow microenvironment in hairy cell leukaemia identifies prognostic tumour and immune related biomarkers

• Published in: Scientific reports Vol. 11; no. 1; p. 19056
• Main Authors: Koldej, Rachel M., Prabahran, Ashvind, Tan, Chin Wee, Ng, Ashley P., Davis, Melissa J., Ritchie, David S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.09.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/1647/48; 631/1647/664/1257; 692/308/53/2422; 692/308/575; 692/4028/67/1990; 692/4028/67/327; 692/4028/67/580; Adult; Bioinformatics; Biomarkers; Biomarkers, Tumor - metabolism; Bone marrow; Case-Control Studies; CD11c antigen; CD14 antigen; CD20 antigen; CD8 antigen; Cladribine; CTLA-4 protein; Experimental design; Female; Histocompatibility antigen HLA; Humanities and Social Sciences; Humans; Immunology; Infiltration; Leukemia; Leukemia, Hairy Cell - immunology; Leukemia, Hairy Cell - metabolism; Leukemia, Hairy Cell - pathology; Lymphocytes B; Lymphocytes T; Major Histocompatibility Complex - immunology; Male; Malignancy; Metastases; Microenvironments; Middle Aged; multidisciplinary; Ox40L protein; Prognosis; Science; Science (multidisciplinary); Spatial analysis; Tumor Microenvironment; Tumors

Hairy cell leukaemia (HCL) is a rare CD20+ B cell malignancy characterised by rare “hairy” B cells and extensive bone marrow (BM) infiltration. Frontline treatment with the purine analogue cladribine (CDA) results in a highly variable response duration. We hypothesised that analysis of the BM tumour...