Dissection of the bone marrow microenvironment in hairy cell leukaemia identifies prognostic tumour and immune related biomarkers

Hairy cell leukaemia (HCL) is a rare CD20+ B cell malignancy characterised by rare “hairy” B cells and extensive bone marrow (BM) infiltration. Frontline treatment with the purine analogue cladribine (CDA) results in a highly variable response duration. We hypothesised that analysis of the BM tumour...

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Published inScientific reports Vol. 11; no. 1; p. 19056
Main Authors Koldej, Rachel M., Prabahran, Ashvind, Tan, Chin Wee, Ng, Ashley P., Davis, Melissa J., Ritchie, David S.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 24.09.2021
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Abstract Hairy cell leukaemia (HCL) is a rare CD20+ B cell malignancy characterised by rare “hairy” B cells and extensive bone marrow (BM) infiltration. Frontline treatment with the purine analogue cladribine (CDA) results in a highly variable response duration. We hypothesised that analysis of the BM tumour microenvironment would identify prognostic biomarkers of response to CDA. HCL BM immunology pre and post CDA treatment and healthy controls were analysed using Digital Spatial Profiling to assess the expression of 57 proteins using an immunology panel. A bioinformatics pipeline was developed to accommodate the more complex experimental design of a spatially resolved study. Treatment with CDA was associated with the reduction in expression of HCL tumour markers (CD20, CD11c) and increased expression of myeloid markers (CD14, CD68, CD66b, ARG1). Expression of HLA-DR, STING, CTLA4, VISTA, OX40L were dysregulated pre- and post-CDA. Duration of response to treatment was associated with greater reduction in tumour burden and infiltration by CD8 T cells into the BM post-CDA. This is the first study to provide a high multiplex analysis of HCL BM microenvironment demonstrating significant immune dysregulation and identify biomarkers of response to CDA. With validation in future studies, prospective application of these biomarkers could allow early identification and increased monitoring in patients at increased relapse risk post CDA.
AbstractList Hairy cell leukaemia (HCL) is a rare CD20+ B cell malignancy characterised by rare “hairy” B cells and extensive bone marrow (BM) infiltration. Frontline treatment with the purine analogue cladribine (CDA) results in a highly variable response duration. We hypothesised that analysis of the BM tumour microenvironment would identify prognostic biomarkers of response to CDA. HCL BM immunology pre and post CDA treatment and healthy controls were analysed using Digital Spatial Profiling to assess the expression of 57 proteins using an immunology panel. A bioinformatics pipeline was developed to accommodate the more complex experimental design of a spatially resolved study. Treatment with CDA was associated with the reduction in expression of HCL tumour markers (CD20, CD11c) and increased expression of myeloid markers (CD14, CD68, CD66b, ARG1). Expression of HLA-DR, STING, CTLA4, VISTA, OX40L were dysregulated pre- and post-CDA. Duration of response to treatment was associated with greater reduction in tumour burden and infiltration by CD8 T cells into the BM post-CDA. This is the first study to provide a high multiplex analysis of HCL BM microenvironment demonstrating significant immune dysregulation and identify biomarkers of response to CDA. With validation in future studies, prospective application of these biomarkers could allow early identification and increased monitoring in patients at increased relapse risk post CDA.
Abstract Hairy cell leukaemia (HCL) is a rare CD20+ B cell malignancy characterised by rare “hairy” B cells and extensive bone marrow (BM) infiltration. Frontline treatment with the purine analogue cladribine (CDA) results in a highly variable response duration. We hypothesised that analysis of the BM tumour microenvironment would identify prognostic biomarkers of response to CDA. HCL BM immunology pre and post CDA treatment and healthy controls were analysed using Digital Spatial Profiling to assess the expression of 57 proteins using an immunology panel. A bioinformatics pipeline was developed to accommodate the more complex experimental design of a spatially resolved study. Treatment with CDA was associated with the reduction in expression of HCL tumour markers (CD20, CD11c) and increased expression of myeloid markers (CD14, CD68, CD66b, ARG1). Expression of HLA-DR, STING, CTLA4, VISTA, OX40L were dysregulated pre- and post-CDA. Duration of response to treatment was associated with greater reduction in tumour burden and infiltration by CD8 T cells into the BM post-CDA. This is the first study to provide a high multiplex analysis of HCL BM microenvironment demonstrating significant immune dysregulation and identify biomarkers of response to CDA. With validation in future studies, prospective application of these biomarkers could allow early identification and increased monitoring in patients at increased relapse risk post CDA.
ArticleNumber 19056
Author Koldej, Rachel M.
Ritchie, David S.
Ng, Ashley P.
Davis, Melissa J.
Prabahran, Ashvind
Tan, Chin Wee
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  givenname: Chin Wee
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Cites_doi 10.1002/acn3.51206
10.1080/10428194.2019.1608536
10.1182/blood.V75.7.1525.1525
10.3390/cancers13020186
10.1182/blood.V83.12.3672.3672
10.1038/nature07317
10.1186/gb-2010-11-3-r25
10.3109/10428199609093449
10.3109/10428199809050927
10.1093/nar/gkv007
10.1182/blood.V83.10.2906.2906
10.1038/s41408-020-00384-1
10.1006/clim.1999.4794
10.1002/cyto.b.21785
10.1016/j.hoc.2006.06.012
10.1093/bioinformatics/btp053
10.1016/0046-8177(92)90239-y
10.1016/j.jns.2013.06.003
10.1371/journal.pone.0191629
10.1186/gb-2014-15-2-r29
10.1182/bloodadvances.2019000792
10.1093/bioinformatics/bti270
10.1038/s41408-020-0328-z
10.1177/1756286419854986
10.1111/bjh.14524
10.1046/j.1365-2257.2001.00417.x
10.1038/sj.leu.2401476
10.1016/j.intimp.2013.11.027
10.1159/000203677
10.1016/j.iotech.2020.02.001
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References Van De Corput, Falkenburg, Kluin-Nelemans (CR25) 1998; 30
Koldej, Ritchie (CR14) 2020; 5
van de Corput, Falkenburg, Kester, Willemze, Kluin-Nelemans (CR9) 1999; 93
Kumar (CR6) 2020; 10
McCarthy, Smyth (CR33) 2009; 25
Seymour, Kurzrock, Freireich, Estey (CR20) 1994; 83
Vedantham, Gamliel, Golomb (CR27) 1992; 52
Kreitman (CR2) 2019; 60
Thompson, Ravandi (CR13) 2017; 177
Kraus (CR24) 2014; 18
Law, Chen, Shi, Smyth (CR32) 2014; 15
Rutella (CR15) 1996; 21
Ritchie (CR30) 2015; 43
Salem (CR4) 2019; 96
Matutes (CR12) 2006; 20
Tytherleigh, Taparia, Leahy (CR5) 2001; 23
Schirmer, Hilbe, Geisen, Thaler, Konwalinka (CR18) 1997; 97
Stuve (CR22) 2019; 12
Knight, Worman, Cawley (CR7) 1983; 53
Raspadori (CR11) 1999; 13
Paillassa (CR1) 2020; 10
Trentin (CR8) 1990; 75
Moser (CR21) 2020; 7
Robinson, Oshlack (CR29) 2010; 11
Juliusson, Lenkei, Liliemark (CR19) 1994; 83
Bauer (CR17) 2021
Bruck (CR16) 2020; 4
Mitosek-Szewczyk (CR23) 2013; 332
Ishikawa, Barber (CR26) 2008; 455
van der Horst, van der Marel, den Ottolander, Kluin-Nelemans (CR10) 1993; 7
Smyth, Michaud, Scott (CR31) 2005; 21
Stroup, Sheibani (CR3) 1992; 23
Gandolfo, Speed (CR28) 2018; 13
RA Knight (98536_CR7) 1983; 53
DJ McCarthy (98536_CR33) 2009; 25
P Kumar (98536_CR6) 2020; 10
DA Salem (98536_CR4) 2019; 96
M Bauer (98536_CR17) 2021
SH Kraus (98536_CR24) 2014; 18
T Moser (98536_CR21) 2020; 7
JF Seymour (98536_CR20) 1994; 83
MD Robinson (98536_CR29) 2010; 11
CW Law (98536_CR32) 2014; 15
K Mitosek-Szewczyk (98536_CR23) 2013; 332
J Paillassa (98536_CR1) 2020; 10
H Ishikawa (98536_CR26) 2008; 455
L Tytherleigh (98536_CR5) 2001; 23
RJ Kreitman (98536_CR2) 2019; 60
S Rutella (98536_CR15) 1996; 21
R Koldej (98536_CR14) 2020; 5
PA Thompson (98536_CR13) 2017; 177
M Schirmer (98536_CR18) 1997; 97
FA van der Horst (98536_CR10) 1993; 7
O Bruck (98536_CR16) 2020; 4
L van de Corput (98536_CR9) 1999; 93
O Stuve (98536_CR22) 2019; 12
G Juliusson (98536_CR19) 1994; 83
LC Gandolfo (98536_CR28) 2018; 13
GK Smyth (98536_CR31) 2005; 21
S Vedantham (98536_CR27) 1992; 52
R Stroup (98536_CR3) 1992; 23
D Raspadori (98536_CR11) 1999; 13
L Van De Corput (98536_CR25) 1998; 30
L Trentin (98536_CR8) 1990; 75
ME Ritchie (98536_CR30) 2015; 43
E Matutes (98536_CR12) 2006; 20
References_xml – volume: 7
  start-page: 2199
  year: 2020
  end-page: 2212
  ident: CR21
  article-title: Long-term peripheral immune cell profiling reveals further targets of oral cladribine in MS
  publication-title: Ann. Clin. Transl. Neurol.
  doi: 10.1002/acn3.51206
  contributor:
    fullname: Moser
– volume: 60
  start-page: 2869
  year: 2019
  end-page: 2879
  ident: CR2
  article-title: Hairy cell leukemia: present and future directions
  publication-title: Leuk. Lymphoma
  doi: 10.1080/10428194.2019.1608536
  contributor:
    fullname: Kreitman
– volume: 75
  start-page: 1525
  year: 1990
  end-page: 1530
  ident: CR8
  article-title: Mechanisms accounting for the defective natural killer activity in patients with hairy cell leukemia
  publication-title: Blood
  doi: 10.1182/blood.V75.7.1525.1525
  contributor:
    fullname: Trentin
– year: 2021
  ident: CR17
  article-title: Altered spatial composition of the immune cell repertoire in association to CD34(+) blasts in myelodysplastic syndromes and secondary acute myeloid leukemia
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers13020186
  contributor:
    fullname: Bauer
– volume: 83
  start-page: 3672
  year: 1994
  end-page: 3681
  ident: CR19
  article-title: Flow cytometry of blood and bone marrow cells from patients with hairy cell leukemia: phenotype of hairy cells and lymphocyte subsets after treatment with 2-chlorodeoxyadenosine
  publication-title: Blood
  doi: 10.1182/blood.V83.12.3672.3672
  contributor:
    fullname: Liliemark
– volume: 455
  start-page: 674
  year: 2008
  end-page: 678
  ident: CR26
  article-title: STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
  publication-title: Nature
  doi: 10.1038/nature07317
  contributor:
    fullname: Barber
– volume: 11
  start-page: R25
  year: 2010
  ident: CR29
  article-title: A scaling normalization method for differential expression analysis of RNA-seq data
  publication-title: Genome Biol.
  doi: 10.1186/gb-2010-11-3-r25
  contributor:
    fullname: Oshlack
– volume: 21
  start-page: 497
  year: 1996
  end-page: 500
  ident: CR15
  article-title: Flow cytometric detection of CD44 (H-CAM) in hairy cell leukemia
  publication-title: Leuk. Lymphoma
  doi: 10.3109/10428199609093449
  contributor:
    fullname: Rutella
– volume: 30
  start-page: 31
  year: 1998
  end-page: 39
  ident: CR25
  article-title: T-cell dysfunction in hairy cell leukemia: an updated review
  publication-title: Leuk. Lymphoma
  doi: 10.3109/10428199809050927
  contributor:
    fullname: Kluin-Nelemans
– volume: 43
  start-page: e47
  year: 2015
  end-page: e47
  ident: CR30
  article-title: limma powers differential expression analyses for RNA-sequencing and microarray studies
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv007
  contributor:
    fullname: Ritchie
– volume: 7
  start-page: 46
  year: 1993
  end-page: 50
  ident: CR10
  article-title: Decrease of memory T helper cells (CD4+ CD45R0+) in hairy cell leukemia
  publication-title: Leukemia
  contributor:
    fullname: Kluin-Nelemans
– volume: 83
  start-page: 2906
  year: 1994
  end-page: 2911
  ident: CR20
  article-title: 2-chlorodeoxyadenosine induces durable remissions and prolonged suppression of CD4+ lymphocyte counts in patients with hairy cell leukemia
  publication-title: Blood
  doi: 10.1182/blood.V83.10.2906.2906
  contributor:
    fullname: Estey
– volume: 10
  start-page: 115
  year: 2020
  ident: CR6
  article-title: Hairy cell leukemia expresses programmed death-1
  publication-title: Blood Cancer J.
  doi: 10.1038/s41408-020-00384-1
  contributor:
    fullname: Kumar
– volume: 93
  start-page: 256
  year: 1999
  end-page: 262
  ident: CR9
  article-title: Impaired expression of CD28 on T cells in hairy cell leukemia
  publication-title: Clin. Immunol.
  doi: 10.1006/clim.1999.4794
  contributor:
    fullname: Kluin-Nelemans
– volume: 96
  start-page: 275
  year: 2019
  end-page: 282
  ident: CR4
  article-title: Differential expression of CD43, CD81, and CD200 in classic versus variant hairy cell leukemia
  publication-title: Cytometry Part B Clin. Cytom.
  doi: 10.1002/cyto.b.21785
  contributor:
    fullname: Salem
– volume: 20
  start-page: 1051
  year: 2006
  end-page: 1063
  ident: CR12
  article-title: Immunophenotyping and differential diagnosis of hairy cell leukemia
  publication-title: Hematol. Oncol. Clin. North Am.
  doi: 10.1016/j.hoc.2006.06.012
  contributor:
    fullname: Matutes
– volume: 52
  start-page: 1056
  year: 1992
  end-page: 1066
  ident: CR27
  article-title: Mechanism of interferon action in hairy cell leukemia: a model of effective cancer biotherapy
  publication-title: Can. Res.
  contributor:
    fullname: Golomb
– volume: 25
  start-page: 765
  year: 2009
  end-page: 771
  ident: CR33
  article-title: Testing significance relative to a fold-change threshold is a TREAT
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp053
  contributor:
    fullname: Smyth
– volume: 23
  start-page: 172
  year: 1992
  end-page: 177
  ident: CR3
  article-title: Antigenic phenotypes of hairy cell leukemia and monocytoid B-cell lymphoma: an immunohistochemical evaluation of 66 cases
  publication-title: Hum. Pathol.
  doi: 10.1016/0046-8177(92)90239-y
  contributor:
    fullname: Sheibani
– volume: 332
  start-page: 35
  year: 2013
  end-page: 40
  ident: CR23
  article-title: Impact of cladribine therapy on changes in circulating dendritic cell subsets, T cells and B cells in patients with multiple sclerosis
  publication-title: J. Neurol. Sci.
  doi: 10.1016/j.jns.2013.06.003
  contributor:
    fullname: Mitosek-Szewczyk
– volume: 13
  year: 2018
  ident: CR28
  article-title: RLE plots: Visualizing unwanted variation in high dimensional data
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0191629
  contributor:
    fullname: Speed
– volume: 15
  start-page: R29
  year: 2014
  ident: CR32
  article-title: voom: precision weights unlock linear model analysis tools for RNA-seq read counts
  publication-title: Genome Biol.
  doi: 10.1186/gb-2014-15-2-r29
  contributor:
    fullname: Smyth
– volume: 4
  start-page: 274
  year: 2020
  end-page: 286
  ident: CR16
  article-title: Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival
  publication-title: Blood Adv.
  doi: 10.1182/bloodadvances.2019000792
  contributor:
    fullname: Bruck
– volume: 21
  start-page: 2067
  year: 2005
  end-page: 2075
  ident: CR31
  article-title: Use of within-array replicate spots for assessing differential expression in microarray experiments
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bti270
  contributor:
    fullname: Scott
– volume: 10
  start-page: 62
  year: 2020
  ident: CR1
  article-title: Analysis of a cohort of 279 patients with hairy-cell leukemia (HCL): 10 years of follow-up
  publication-title: Blood Cancer J.
  doi: 10.1038/s41408-020-0328-z
  contributor:
    fullname: Paillassa
– volume: 53
  start-page: 600
  year: 1983
  end-page: 604
  ident: CR7
  article-title: Defective autologous and allogeneic mixed lymphocyte reactions in hairy cell leukaemia
  publication-title: Clin. Exp. Immunol.
  contributor:
    fullname: Cawley
– volume: 12
  start-page: 1756286419854986
  year: 2019
  ident: CR22
  article-title: Effects of cladribine tablets on lymphocyte subsets in patients with multiple sclerosis: an extended analysis of surface markers
  publication-title: Ther. Adv. Neurol. Disord.
  doi: 10.1177/1756286419854986
  contributor:
    fullname: Stuve
– volume: 177
  start-page: 543
  year: 2017
  end-page: 556
  ident: CR13
  article-title: How I manage patients with hairy cell leukaemia
  publication-title: Br. J. Haematol.
  doi: 10.1111/bjh.14524
  contributor:
    fullname: Ravandi
– volume: 23
  start-page: 385
  year: 2001
  end-page: 390
  ident: CR5
  article-title: Detection of hairy cell leukaemia in blood and bone marrow using multidimensional flow cytometry with CD45-PECy5 and SS gating
  publication-title: Clin. Lab. Haematol.
  doi: 10.1046/j.1365-2257.2001.00417.x
  contributor:
    fullname: Leahy
– volume: 13
  start-page: 1254
  year: 1999
  end-page: 1257
  ident: CR11
  article-title: Long-lasting decrease of CD4+/CD45RA+ T cells in HCL patients after 2-chlorodeoxyadenosine (2-CdA) treatment
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2401476
  contributor:
    fullname: Raspadori
– volume: 18
  start-page: 347
  year: 2014
  end-page: 357
  ident: CR24
  article-title: Cladribine exerts an immunomodulatory effect on human and murine dendritic cells
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2013.11.027
  contributor:
    fullname: Kraus
– volume: 97
  start-page: 180
  year: 1997
  end-page: 183
  ident: CR18
  article-title: T cells and natural killer cells after treatment of hairy cell leukaemia with 2-chlorodeoxyadenosine
  publication-title: Acta Haematol.
  doi: 10.1159/000203677
  contributor:
    fullname: Konwalinka
– volume: 5
  start-page: 1
  year: 2020
  end-page: 9
  ident: CR14
  article-title: High multiplex analysis of the immune microenvironment in bone marrow trephine samples using GeoMX digital spatial profiling
  publication-title: Immuno-Oncol. Technol.
  doi: 10.1016/j.iotech.2020.02.001
  contributor:
    fullname: Ritchie
– volume: 21
  start-page: 2067
  year: 2005
  ident: 98536_CR31
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bti270
  contributor:
    fullname: GK Smyth
– volume: 83
  start-page: 2906
  year: 1994
  ident: 98536_CR20
  publication-title: Blood
  doi: 10.1182/blood.V83.10.2906.2906
  contributor:
    fullname: JF Seymour
– year: 2021
  ident: 98536_CR17
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers13020186
  contributor:
    fullname: M Bauer
– volume: 43
  start-page: e47
  year: 2015
  ident: 98536_CR30
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv007
  contributor:
    fullname: ME Ritchie
– volume: 4
  start-page: 274
  year: 2020
  ident: 98536_CR16
  publication-title: Blood Adv.
  doi: 10.1182/bloodadvances.2019000792
  contributor:
    fullname: O Bruck
– volume: 11
  start-page: R25
  year: 2010
  ident: 98536_CR29
  publication-title: Genome Biol.
  doi: 10.1186/gb-2010-11-3-r25
  contributor:
    fullname: MD Robinson
– volume: 15
  start-page: R29
  year: 2014
  ident: 98536_CR32
  publication-title: Genome Biol.
  doi: 10.1186/gb-2014-15-2-r29
  contributor:
    fullname: CW Law
– volume: 332
  start-page: 35
  year: 2013
  ident: 98536_CR23
  publication-title: J. Neurol. Sci.
  doi: 10.1016/j.jns.2013.06.003
  contributor:
    fullname: K Mitosek-Szewczyk
– volume: 75
  start-page: 1525
  year: 1990
  ident: 98536_CR8
  publication-title: Blood
  doi: 10.1182/blood.V75.7.1525.1525
  contributor:
    fullname: L Trentin
– volume: 60
  start-page: 2869
  year: 2019
  ident: 98536_CR2
  publication-title: Leuk. Lymphoma
  doi: 10.1080/10428194.2019.1608536
  contributor:
    fullname: RJ Kreitman
– volume: 13
  start-page: 1254
  year: 1999
  ident: 98536_CR11
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2401476
  contributor:
    fullname: D Raspadori
– volume: 97
  start-page: 180
  year: 1997
  ident: 98536_CR18
  publication-title: Acta Haematol.
  doi: 10.1159/000203677
  contributor:
    fullname: M Schirmer
– volume: 52
  start-page: 1056
  year: 1992
  ident: 98536_CR27
  publication-title: Can. Res.
  contributor:
    fullname: S Vedantham
– volume: 93
  start-page: 256
  year: 1999
  ident: 98536_CR9
  publication-title: Clin. Immunol.
  doi: 10.1006/clim.1999.4794
  contributor:
    fullname: L van de Corput
– volume: 7
  start-page: 46
  year: 1993
  ident: 98536_CR10
  publication-title: Leukemia
  contributor:
    fullname: FA van der Horst
– volume: 455
  start-page: 674
  year: 2008
  ident: 98536_CR26
  publication-title: Nature
  doi: 10.1038/nature07317
  contributor:
    fullname: H Ishikawa
– volume: 21
  start-page: 497
  year: 1996
  ident: 98536_CR15
  publication-title: Leuk. Lymphoma
  doi: 10.3109/10428199609093449
  contributor:
    fullname: S Rutella
– volume: 13
  year: 2018
  ident: 98536_CR28
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0191629
  contributor:
    fullname: LC Gandolfo
– volume: 23
  start-page: 385
  year: 2001
  ident: 98536_CR5
  publication-title: Clin. Lab. Haematol.
  doi: 10.1046/j.1365-2257.2001.00417.x
  contributor:
    fullname: L Tytherleigh
– volume: 177
  start-page: 543
  year: 2017
  ident: 98536_CR13
  publication-title: Br. J. Haematol.
  doi: 10.1111/bjh.14524
  contributor:
    fullname: PA Thompson
– volume: 23
  start-page: 172
  year: 1992
  ident: 98536_CR3
  publication-title: Hum. Pathol.
  doi: 10.1016/0046-8177(92)90239-y
  contributor:
    fullname: R Stroup
– volume: 7
  start-page: 2199
  year: 2020
  ident: 98536_CR21
  publication-title: Ann. Clin. Transl. Neurol.
  doi: 10.1002/acn3.51206
  contributor:
    fullname: T Moser
– volume: 83
  start-page: 3672
  year: 1994
  ident: 98536_CR19
  publication-title: Blood
  doi: 10.1182/blood.V83.12.3672.3672
  contributor:
    fullname: G Juliusson
– volume: 10
  start-page: 115
  year: 2020
  ident: 98536_CR6
  publication-title: Blood Cancer J.
  doi: 10.1038/s41408-020-00384-1
  contributor:
    fullname: P Kumar
– volume: 25
  start-page: 765
  year: 2009
  ident: 98536_CR33
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp053
  contributor:
    fullname: DJ McCarthy
– volume: 18
  start-page: 347
  year: 2014
  ident: 98536_CR24
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2013.11.027
  contributor:
    fullname: SH Kraus
– volume: 30
  start-page: 31
  year: 1998
  ident: 98536_CR25
  publication-title: Leuk. Lymphoma
  doi: 10.3109/10428199809050927
  contributor:
    fullname: L Van De Corput
– volume: 53
  start-page: 600
  year: 1983
  ident: 98536_CR7
  publication-title: Clin. Exp. Immunol.
  contributor:
    fullname: RA Knight
– volume: 10
  start-page: 62
  year: 2020
  ident: 98536_CR1
  publication-title: Blood Cancer J.
  doi: 10.1038/s41408-020-0328-z
  contributor:
    fullname: J Paillassa
– volume: 5
  start-page: 1
  year: 2020
  ident: 98536_CR14
  publication-title: Immuno-Oncol. Technol.
  doi: 10.1016/j.iotech.2020.02.001
  contributor:
    fullname: R Koldej
– volume: 12
  start-page: 175628641985498
  year: 2019
  ident: 98536_CR22
  publication-title: Ther. Adv. Neurol. Disord.
  doi: 10.1177/1756286419854986
  contributor:
    fullname: O Stuve
– volume: 96
  start-page: 275
  year: 2019
  ident: 98536_CR4
  publication-title: Cytometry Part B Clin. Cytom.
  doi: 10.1002/cyto.b.21785
  contributor:
    fullname: DA Salem
– volume: 20
  start-page: 1051
  year: 2006
  ident: 98536_CR12
  publication-title: Hematol. Oncol. Clin. North Am.
  doi: 10.1016/j.hoc.2006.06.012
  contributor:
    fullname: E Matutes
SSID ssj0000529419
Score 2.436993
Snippet Hairy cell leukaemia (HCL) is a rare CD20+ B cell malignancy characterised by rare “hairy” B cells and extensive bone marrow (BM) infiltration. Frontline...
Hairy cell leukaemia (HCL) is a rare CD20+ B cell malignancy characterised by rare "hairy" B cells and extensive bone marrow (BM) infiltration. Frontline...
Abstract Hairy cell leukaemia (HCL) is a rare CD20+ B cell malignancy characterised by rare “hairy” B cells and extensive bone marrow (BM) infiltration....
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StartPage 19056
SubjectTerms 631/1647/48
631/1647/664/1257
692/308/53/2422
692/308/575
692/4028/67/1990
692/4028/67/327
692/4028/67/580
Adult
Bioinformatics
Biomarkers
Biomarkers, Tumor - metabolism
Bone marrow
Case-Control Studies
CD11c antigen
CD14 antigen
CD20 antigen
CD8 antigen
Cladribine
CTLA-4 protein
Experimental design
Female
Histocompatibility antigen HLA
Humanities and Social Sciences
Humans
Immunology
Infiltration
Leukemia
Leukemia, Hairy Cell - immunology
Leukemia, Hairy Cell - metabolism
Leukemia, Hairy Cell - pathology
Lymphocytes B
Lymphocytes T
Major Histocompatibility Complex - immunology
Male
Malignancy
Metastases
Microenvironments
Middle Aged
multidisciplinary
Ox40L protein
Prognosis
Science
Science (multidisciplinary)
Spatial analysis
Tumor Microenvironment
Tumors
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Title Dissection of the bone marrow microenvironment in hairy cell leukaemia identifies prognostic tumour and immune related biomarkers
URI https://link.springer.com/article/10.1038/s41598-021-98536-1
https://www.ncbi.nlm.nih.gov/pubmed/34561502
https://www.proquest.com/docview/2576118737
https://search.proquest.com/docview/2576655078
https://pubmed.ncbi.nlm.nih.gov/PMC8463612
https://doaj.org/article/aae490569fd64e0cb55a0a2f7e4b5132
Volume 11
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