Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

• Published in: Nature communications Vol. 11; no. 1; pp. 4755 - 17
• Main Authors: Wu, Xue, Niculite, Cristina M., Preda, Mihai Bogdan, Rossi, Annalisa, Tebaldi, Toma, Butoi, Elena, White, Mattie K., Tudoran, Oana M., Petrusca, Daniela N., Jannasch, Amber S., Bone, William P., Zong, Xingyue, Fang, Fang, Burlacu, Alexandrina, Paulsen, Michelle T., Hancock, Brad A., Sandusky, George E., Mitra, Sumegha, Fishel, Melissa L., Buechlein, Aaron, Ivan, Cristina, Oikonomopoulos, Spyros, Gorospe, Myriam, Mosley, Amber, Radovich, Milan, Davé, Utpal P., Ragoussis, Jiannis, Nephew, Kenneth P., Mari, Bernard, McIntyre, Alan, Konig, Heiko, Ljungman, Mats, Cousminer, Diana L., Macchi, Paolo, Ivan, Mircea
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.09.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 101/58; 13/109; 13/89; 13/95; 14/32; 38/43; 38/79; 45/15; 45/47; 49/91; 631/337/384/2568; 631/443/319/1557; Basic Helix-Loop-Helix Transcription Factors - metabolism; Biosynthesis; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus - metabolism; Cholesterol; Cholesterol - metabolism; Estrogens; Estrogens - metabolism; Gene Expression Regulation; Genetic diversity; Genome-Wide Association Study; Heterogeneous-Nuclear Ribonucleoprotein Group C - genetics; Heterogeneous-Nuclear Ribonucleoprotein Group C - metabolism; Homeostasis; Humanities and Social Sciences; Humans; Hypoxia; In vivo methods and tests; Loci; MCF-7 Cells; multidisciplinary; Oxygen; Oxygen - metabolism; Phenotype; Phenotypes; Polymorphism, Single Nucleotide; Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Long Noncoding - physiology; RNA-binding protein; Science; Science (multidisciplinary); Steroids; Sterols; Sterols - biosynthesis

We hereby provide the initial portrait of lincNORS , a spliced lincRNA generated by the MIR193BHG locus, entirely distinct from the previously described miR-193b-365a tandem. While inducible by low O 2 in a variety of cells and associated with hypoxia in vivo, our studies show that lincNORS is subje...