The SNPs of mitochondrial DNA displacement loop region and mitochondrial DNA copy number associated with risk of polymyositis and dermatomyositis

• Published in: Scientific reports Vol. 12; no. 1; pp. 5903 - 7
• Main Authors: Zhao, Yufei, Peng, Chenxing, Lai, Ruixue, Zhang, Jingjing, Zhang, Xiaoyun, Guo, Zhanjun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/127/1213; 631/443/319/333; 692/4023/1670/246; 692/53/2423; Alleles; Antinuclear antibodies; Autophagy; Copy number; Dermatomyositis; Dermatomyositis - complications; Dermatomyositis - genetics; DNA Copy Number Variations; DNA, Mitochondrial - genetics; Humanities and Social Sciences; Humans; Inflammation; Interleukin 2; Interleukin 4; Mitochondria - genetics; Mitochondrial DNA; multidisciplinary; Polymorphism, Single Nucleotide; Polymyositis; Polymyositis - complications; Polymyositis - genetics; Reactive oxygen species; Science; Science (multidisciplinary); Single-nucleotide polymorphism
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-09943-x

Oxidative damage-induced mitochondrial dysfunction may activate muscle catabolism and autophagy pathways to initiate muscle weakening in idiopathic inflammatory myopathies (IIMs). In this study, Single nucleotide polymorphisms (SNPs) in the mitochondrial displacement loop (D-loop) and mitochondrial...