Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer

• Published in: Nature communications Vol. 13; no. 1; pp. 6279 - 12
• Main Authors: Li, Juan-Juan, Hu, Yuqing, Hu, Bing, Wang, Wenbo, Xu, Haiqi, Hu, Xin-Yue, Ding, Fei, Li, Hua-Bin, Wang, Ke-Rang, Zhang, Xinge, Guo, Dong-Sheng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.10.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/21; 13/51; 140/131; 140/58; 147/143; 639/301; 639/638/541; 64/86; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Anti-Infective Agents; Antibiotics; Antiinfectives and antibacterials; Antimicrobial agents; Bacterial diseases; Biofilms; Chronic infection; Ciprofloxacin; Ciprofloxacin - pharmacology; Ciprofloxacin - therapeutic use; Controlled release; Delayed-Action Preparations; Diabetes; Diabetes mellitus; Diabetes Mellitus - drug therapy; Drug delivery; Drug Delivery Systems; Drug development; Drug resistance; Humanities and Social Sciences; Humans; Hypoxia; Hypoxia - drug therapy; Infections; Inflammation; Lactose; Microbial Sensitivity Tests; Microenvironments; multidisciplinary; Multidrug resistance; Multidrug resistant organisms; Pseudomonas aeruginosa; Pseudomonas Infections - drug therapy; Pseudomonas Infections - microbiology; Science; Science (multidisciplinary); Ulcer - drug therapy; Wound healing

Diabetic wound is one of the most intractable chronic wounds that is prone to bacterial infection. Hypoxia is an important feature in its microenvironment. However, it is challenging for antimicrobial therapy to directly apply the existing hypoxia-responsive drug delivery systems due to the active t...